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Does Bactroban cream (mupirocin) cause side effects?
Bactroban cream (mupirocin) is an antibiotic used topically (on the skin) to treat impetigo and infections of the skin caused by Staphylococcus aureus, beta-hemolytic streptococcus, or Streptococcus pyogenes.
The nasal ointment is used for the elimination of multi-drug resistant nasal Staphylococcus aureus infection in people who are colonized by Staphylococcus aureus. Mupirocin also may be used for other secondary infections.
There are no adequate studies of mupirocin in pregnant women. Studies in animals suggest no important effects on the fetus. Mupirocin may be used in pregnancy if the physician feels it is necessary. There is no information on the safety of mupirocin in nursing infants. It is unknown if any of the small amount of mupirocin that is absorbed from the skin into the blood of the mother concentrates in breast milk. It is advisable not to nurse while using mupirocin.
What are the important side effects of Bactroban cream (mupirocin)?
Side effects are uncommon and mild with mupirocin. The most frequent side effects are:
Other side effects caused by the intranasal use of mupirocin include:
Bactroban cream (mupirocin) side effects list for healthcare professionals
The following adverse reactions are discussed in more detail in other sections of the labeling:
Clinical Trials Experience
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice.
In 2 randomized, double-blind, double-dummy trials, 339 subjects were treated with topical Bactroban cream plus oral placebo. Adverse reactions occurred in 28 (8.3%) subjects. The following adverse reactions were reported by at least 1% of subjects in connection with the use of Bactroban cream in clinical trials: headache (1.7%), rash (1.1%), and nausea (1.1%).
Other adverse reactions which occurred in less than 1% of subjects were: abdominal pain, burning at application site, cellulitis, dermatitis, dizziness, pruritus, secondary wound infection, and ulcerative stomatitis.
In a supportive trial in the treatment of secondarily infected eczema, 82 subjects were treated with Bactroban cream. The incidence of adverse reactions was as follows: nausea (4.9%), headache and burning at application site (3.6% each), pruritus (2.4%), and 1 report each of abdominal pain, bleeding secondary to eczema, pain secondary to eczema, hives, dry skin, and rash.
In addition to adverse reactions reported from clinical trials, the following reactions have been identified during postmarketing use of Bactroban cream. Because they are reported voluntarily from a population of unknown size, estimates of frequency cannot be made. These reactions have been chosen for inclusion due to a combination of their seriousness, frequency of reporting, or potential causal relationship to Bactroban cream.
Immune System Disorders
Bactroban cream (mupirocin) is an antibiotic used for treatment of bacterial skin infections to treat impetigo and infections of the skin caused by Staphylococcus aureus, beta-hemolytic streptococcus, or Streptococcus pyogenes. There's a version for the nose as well. Side effects are minor itching and pain at the site of application, or nose and throat problems when taking the nasal version of Bactroban cream.
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Related Disease Conditions
Staph (Staphylococcus) Infection
Staphylococcus or staph is a group of bacteria that can cause a multitude of diseases. Staph infections can cause illness directly by infection or indirectly by the toxins they produce. Symptoms and signs of a staph infection include redness, swelling, pain, and drainage of pus. Minor skin infections are treated with an antibiotic ointment, while more serious infections are treated with intravenous antibiotics.
Impetigo is a contagious skin infection caused by staph and strep bacteria. There are two types of impetigo: nonbullous and bullous. Symptoms of nonbullous impetigo include small blisters on the nose, face, arms, or legs and possibly swollen glands. Bullous impetigo signs include blisters in various areas, particularly in the buttocks area. Treatment involves gentle cleansing, removing the crusts of popped blisters, and the application of prescription-strength mupirocin antibiotic ointment.
Is a Staph Infection Contagious?
A staph infection is caused by the bacteria Staphylococcus aureus. Staph can cause boils, food poisoning, cellulitis, toxic shock syndrome, MRSA, and various other illnesses and infections. Most staph infections are transmitted from person to person.
What Is the Best Treatment for Impetigo?
Impetigo is a bacterial skin infection that causes a rash that forms blisters and can ooze pus, causing a crust. Impetigo can be caused by different kinds of bacteria, including strep and staph. Usually, impetigo is easy to treat and rarely leaves scarring.
Is Impetigo Contagious?
Impetigo is a contagious bacterial infection that usually occurs in children ages 2-5. There are two types of impetigo: bullous and nonbullous. With nonbullous impetigo, pus-filled blisters develop, ooze, and crust over on the patient's torso, in contrast with bullous impetigo, which is typically confined to the extremities and the face near the mouth.
Treatment & Diagnosis
Medications & Supplements
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration