Does Bactroban cream (mupirocin) cause side effects?

Bactroban cream (mupirocin) is an antibiotic used topically (on the skin) to treat impetigo and infections of the skin caused by Staphylococcus aureus, beta-hemolytic streptococcus, or Streptococcus pyogenes.

The nasal ointment is used for the elimination of multi-drug resistant nasal Staphylococcus aureus infection in people who are colonized by Staphylococcus aureus. Mupirocin also may be used for other secondary infections.

Common side effects of mupirocin include application site reactions (burning, stinging, pain, and itching).

Other side effects caused by the intranasal use of mupirocin include headache, runny nose, congestion, sore throat, dry skin, swelling (edema), changes in taste, nasal irritation, and cough.

There are no known drug interactions with mupirocin; however, it should not be used at the same time with other drugs that are applied inside the nose.

There are no adequate studies of mupirocin in pregnant women. Studies in animals suggest no important effects on the fetus. Mupirocin may be used in pregnancy if the physician feels it is necessary. There is no information on the safety of mupirocin in nursing infants. It is unknown if any of the small amount of mupirocin that is absorbed from the skin into the blood of the mother concentrates in breast milk. It is advisable not to nurse while using mupirocin.

What are the important side effects of Bactroban cream (mupirocin)?

Side effects are uncommon and mild with mupirocin. The most frequent side effects are:

Other side effects caused by the intranasal use of mupirocin include:

Bactroban cream (mupirocin) side effects list for healthcare professionals

The following adverse reactions are discussed in more detail in other sections of the labeling:

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice.

In 2 randomized, double-blind, double-dummy trials, 339 subjects were treated with topical Bactroban cream plus oral placebo. Adverse reactions occurred in 28 (8.3%) subjects. The following adverse reactions were reported by at least 1% of subjects in connection with the use of Bactroban cream in clinical trials: headache (1.7%), rash (1.1%), and nausea (1.1%).

Other adverse reactions which occurred in less than 1% of subjects were: abdominal pain, burning at application site, cellulitis, dermatitis, dizziness, pruritus, secondary wound infection, and ulcerative stomatitis.

In a supportive trial in the treatment of secondarily infected eczema, 82 subjects were treated with Bactroban cream. The incidence of adverse reactions was as follows: nausea (4.9%), headache and burning at application site (3.6% each), pruritus (2.4%), and 1 report each of abdominal pain, bleeding secondary to eczema, pain secondary to eczema, hives, dry skin, and rash.

Postmarketing Experience

In addition to adverse reactions reported from clinical trials, the following reactions have been identified during postmarketing use of Bactroban cream. Because they are reported voluntarily from a population of unknown size, estimates of frequency cannot be made. These reactions have been chosen for inclusion due to a combination of their seriousness, frequency of reporting, or potential causal relationship to Bactroban cream.

Immune System Disorders

Systemic allergic reactions, including anaphylaxis, urticaria, angioedema, and generalized rash.

What drugs interact with Bactroban cream (mupirocin)?

No information provided.

Summary

Bactroban cream (mupirocin) is an antibiotic used for treatment of bacterial skin infections to treat impetigo and infections of the skin caused by Staphylococcus aureus, beta-hemolytic streptococcus, or Streptococcus pyogenes. There's a version for the nose as well. Side effects are minor itching and pain at the site of application, or nose and throat problems when taking the nasal version of Bactroban cream.

Treatment & Diagnosis

Medications & Supplements

FDA Logo

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Medically Reviewed on 3/5/2020
References
FDA Prescribing information

Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration
CONTINUE SCROLLING FOR RELATED SLIDESHOW