azelaic acid (Finacea, Azelex)

• Azelaic acid is a topical (applied to the skin) medication used for treating acne. Its exact mechanism of action is unknown. Azelaic acid may work as an antibacterial agent that blocks protein synthesis and therefore growth of Propionibacterium acnes and other bacteria on the surface of the skin that are associated with the development of acne. It may also inhibit follicular keratinization, which prevents development of acne lesions. The FDA approved azelaic acid in September 1995.
• References: FDA prescribing information

What brand names are available for azelaic acid gel?

Finacea, Azelex

Is azelaic acid gel available as a generic drug?

No

Do I need a prescription for azelaic acid gel?

Yes

Azelaic acid is used for the treatment of acne vulgaris and treatment of inflammatory papule and pustules caused by mild to moderate rosacea.

• Common side effects include:
• Burning
• Stinging
• Tingling

Other side effects include:

• Itching
• Dry skin
• Irritation
• Erythema

Other less common side effects include:

• Contact dermatitis
• Edema
• Acne
• Possible serious side effects include:
• Facial burning
• Iridocyclitis after accidental exposure to the eyes
• Worsening of asthma, dyspnea, wheezing
• Serious allergic reactions

A thin layer of azelaic acid should be applied and massaged into the affected areas of the face every 12 hours.

There are no drug interactions listed for this azelaic acid.

• The safety azelaic acid has not been evaluated. It is not known whether azelaic acid is excreted in human milk. However, laboratory experiments suggest that the small amount of azelaic acid that is absorbed into the body may be excreted in human milk at very low concentrations that may not be significant.

What preparations of azelaic acid gel are available?

Gel, Foam, Kit: 15%. Cream: 20%

How should I keep azelaic acid gel stored?

Store azelaic acid between 15 C and 30 C (59 F and 86 F).