Avocado Sugar Extract

Reviewed on 6/11/2021
Other Name(s):

D-Mannoheptulose, Extracto de Azúcar de Aguacate, Extrait de Sucres d'Avocat, Mannoheptulose, Manno-heptulose, Séduheptulose.


Avocado sugar extract is a chemical taken from avocado fruit and used as medicine.

People take avocado sugar extract to lose weight.

How does it work?

Developing research suggests avocado sugar extract might block the effects of insulin and prevent the break down of sugar (glucose).


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Uses & Effectiveness

Insufficient Evidence to Rate Effectiveness for...

More evidence is needed to rate the effectiveness of avocado sugar extract for this use.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

Side Effects

It is not known if avocado sugar extract is safe.


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Special Precautions & Warnings

Pregnancy and breast-feeding: Not enough is known about the use of avocado sugar extract during pregnancy and breast-feeding. Stay on the safe side and avoid use.

Diabetes: There is concern that avocado sugar extract might make diabetes worse because it seems to block the effects of insulin. This reduces the amount of sugar that the body breaks down and increases blood sugar levels.

Surgery: Avocado sugar extract might affect blood sugar levels. There is some concern that it might interfere with blood sugar control during and after surgery. Stop using avocado sugar extract at least 2 weeks before a scheduled surgery.


Medications for diabetes (Antidiabetes drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Avocado sugar extract might increase blood sugar. Diabetes medications are used to lower blood sugar. Taking avocado sugar extract along with diabetes medications might interfere with the blood sugar lowering effects of diabetes medications. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.

Some medications used for diabetes include glimepiride (Amaryl), glyburide (Diabeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.

Before taking avocado sugar extract, talk with your healthcare professional if you take these or any other medications.


The appropriate dose of avocado sugar extract depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for avocado sugar extract. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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Graziani J, Levy J, Dimant E. An inhibitory effect of D-Mannoheptulose on lactate formation in human whole blood in vitro. FEBS Lett 1971;16:241-4. View abstract.

Ladriere L, Kadiata MM, Malaisse WJ. Comparison between the effects of D-mannoheptulose and its hexaacetate ester upon D-glucose metabolism in rat erythrocytes. Horm Metab Res 1998;30:244-5. View abstract.

Malaisse WJ, Doherty M, Kadiata MM, et al. Pancreatic fate of D-[3H] mannoheptulose. Cell Biochem Funct 2001;19:171-9. View abstract.

Rasschaert J, Kadiata MM, Malaisse WJ. Effects of D-mannoheptulose upon D-glucose metabolism in tumoral pancreatic islet cells. Mol Cell Biochem 2001;226:77-81. View abstract.

Sehlin J. Effect of mannoheptulose on the dynamics of glucose oxidation in the pancreatic beta-cells. FEBS Lett 1973;30:45-8. View abstract.

Shaw PE, Wilson CW 3rd, Knight RJ Jr. High-performance liquid chromatographic analysis of D-manno-heptulose, perseitol, glucose, and fructose in avocado cultivars. J Agric Food Chem 1980;28:379-62. View abstract.