Generic drug: ferric citrate
Brand name: Auryxia
What is Auryxia (ferric citrate), and how does it work?
What are the side effects of Auryxia?
Common side effects of Auryxia include:
What is the dosage for Auryxia?
Dosage For Hyperphosphatemia In Chronic Kidney Disease On Dialysis
- The recommended starting dose is 2 tablets, swallowed whole, 3 times per day with meals.
- Auryxia tablets must not be chewed or crushed because it may cause discoloration of mouth and teeth.
- Monitor serum phosphorus levels and titrate the Auryxia dose in decrements or increments of 1 to 2 tablets per day as needed to maintain serum phosphorus at target levels, up to a maximum dose of 12 tablets daily.
- Dose can be titrated at 1-week or longer intervals.
- In a clinical trial, patients required an average of 8 to 9 tablets a day to control serum phosphorus levels.
Dosage For Iron Deficiency Anemia In Chronic Kidney Disease Not On Dialysis
- The recommended starting dose is 1 tablet, swallowed whole, 3 times per day with meals.
- Auryxia tablets must not be chewed or crushed because it may cause discoloration of mouth and teeth.
- Titrate the dose of Auryxia as needed to achieve and maintain hemoglobin at target levels, up to a maximum dose of 12 tablets daily.
- In a clinical trial in patients with chronic kidney disease not on dialysis (CKD-NDD), patients required an average of 5 tablets per day to increase hemoglobin levels.
What drugs interact with Auryxia?
Table 2: Oral drugs that can be administered concomitantly with Auryxia
|Oral drugs that have to be separated from Auryxia and meals|
|Doxycycline||Take at least 1 hour before Auryxia|
|Ciprofloxacin||Take at least 2 hours before or after Auryxia|
Oral Medications Not Listed In Table 2
- There are no empirical data on avoiding drug interactions between Auryxia and most concomitant oral drugs.
- For oral medications where a reduction in the bioavailability of that medication would have a clinically significant effect on its safety or efficacy, consider separation of the timing of the administration of the two drugs.
- The duration of separation depends upon the absorption characteristics of the medication concomitantly administered, such as the time to reach peak systemic levels and whether the drug is an immediate release or an extended release product.
- Consider monitoring clinical responses or blood levels of concomitant medications that have a narrow therapeutic range.
Is Auryxia safe to use while pregnant or breastfeeding?
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Auryxia (ferric citrate) is a phosphate binder used for the control of serum phosphorus levels in patients with chronic kidney disease on dialysis. Common side effects of Auryxia include diarrhea, nausea, constipation, vomiting, cough, and dark stools (related to the iron content).
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