aurothioglucose

  • Pharmacy Author:
    Annette (Gbemudu) Ogbru, PharmD, MBA

    Dr. Gbemudu received her B.S. in Biochemistry from Nova Southeastern University, her PharmD degree from University of Maryland, and MBA degree from University of Baltimore. She completed a one year post-doctoral fellowship with Rutgers University and Bristol Myers Squibb.

  • Medical and Pharmacy Editor: William C. Shiel Jr., MD, FACP, FACR
    William C. Shiel Jr., MD, FACP, FACR

    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

Symptoms of Rheumatoid Arthritis

What is aurothioglucose, and how does it work (mechanism of action)?

Aurothioglucose is a gold-containing chemical (salt) used for treating rheumatoid arthritis. Other gold salts available include injectable gold sodium thiomalate (Myochrysine), and capsules, auranofin (Ridaura). It is not well understood exactly how gold salts work. In patients with inflammatory arthritis, such as adult and juvenile rheumatoid arthritis, gold salts can decrease the inflammation of the joint lining. This effect prevents the inflammation from destroying the bone and cartilage surrounding the joints and prevents or slows the development of deformities of the joints. Because of their ability to prevent deformities, gold salts are referred to as disease modifying anti-rheumatic drugs (DMARDs). DMARDs like aurothioglucose may take weeks to months to become effective.

What brand names are available for aurothioglucose?

Solganal

Is aurothioglucose available as a generic drug?

GENERIC AVAILABLE: No

Do I need a prescription for aurothioglucose?

Yes

What are the side effects of aurothioglucose?

The most common adverse reactions to aurothioglucose is dermatitis (skin inflammation), pruritus (itching), stomatitis (inflammation affecting the structures in the mouth such as cheeks, gums, tongue, lips, throat). Aurothoglucose can also suppress the bone marrow leading to abnormally low blood counts, including leukopenia, thrombocytopenia, and anemia. It can also cause kidney damage manifest by protein loss in the urine.

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What is the dosage for aurothioglucose?

The usual initial adult dose is 10 mg followed by 25 mg for the second and third doses, then 50 mg weekly until 0.8 to1 g has been administered. The usual dose for children is one-fourth of the adult dose of aurothioglucose, exceeding 25 mg per dose.

Which drugs or supplements interact with aurothioglucose?

The concurrent use of penicillamine (Cuprimine, Depen) and aurothioglucose should be avoided as the combination decreases the levels and efficacy of both drugs due to chelation (binding) of the gold salt to the penicillamine.

Is aurothioglucose safe to take if I'm pregnant or breastfeeding?

There are no adequate and well-controlled studies in pregnant women. Aurothioglucose should be used during pregnancy only if the potential benefit to the mother justifies the potential risk to the fetus.

Aurothioglucose has been found in the breast milk of women. Due to the potential for serious adverse reactions in nursing infants, decisions should be made whether to discontinue nursing or to discontinue the drug.

What else should I know about aurothioglucose?

What preparations of aurothioglucose are available?

Injectable suspension: 50 mg/ml.

How should I keep aurothioglucose stored?

Aurothioglucose should be stored at room temperature between 59 F and 86 F (15 C-30 C) away from light and moisture and should not be frozen.

REFERENCE: FDA Prescribing Information

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Summary

Aurothioglucose (Solganal) is a medications prescribed for the treatment of rheumatoid arthritis, juvenile rheumatoid arthritis, and Felty's syndrome. Side effects, drug interactions, warnings and precautions, and patient information should be reviewed prior to taking any medication.

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Reviewed on 8/7/2017
References
REFERENCE: FDA Prescribing Information

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