- What is aurothioglucose, and how does it work (mechanism of action)?
- What brand names are available for aurothioglucose?
- Is aurothioglucose available as a generic drug?
- Do I need a prescription for aurothioglucose?
- What are the side effects of aurothioglucose?
- What is the dosage for aurothioglucose?
- Which drugs or supplements interact with aurothioglucose?
- Is aurothioglucose safe to take if I'm pregnant or breastfeeding?
- What else should I know about aurothioglucose?
What is aurothioglucose, and how does it work (mechanism of action)?
Aurothioglucose is a gold-containing chemical (salt) used for treating rheumatoid arthritis. Other gold salts available include injectable gold sodium thiomalate (Myochrysine), and capsules, auranofin (Ridaura). It is not well understood exactly how gold salts work. In patients with inflammatory arthritis, such as adult and juvenile rheumatoid arthritis, gold salts can decrease the inflammation of the joint lining. This effect prevents the inflammation from destroying the bone and cartilage surrounding the joints and prevents or slows the development of deformities of the joints. Because of their ability to prevent deformities, gold salts are referred to as disease modifying anti-rheumatic drugs (DMARDs). DMARDs like aurothioglucose may take weeks to months to become effective.
What are the side effects of aurothioglucose?
The most common adverse reactions to aurothioglucose is dermatitis (skin inflammation), pruritus (itching), stomatitis (inflammation affecting the structures in the mouth such as cheeks, gums, tongue, lips, throat). Aurothoglucose can also suppress the bone marrow leading to abnormally low blood counts, including leukopenia, thrombocytopenia, and anemia. It can also cause kidney damage manifest by protein loss in the urine.
What is the dosage for aurothioglucose?
The usual initial adult dose is 10 mg followed by 25 mg for the second and third doses, then 50 mg weekly until 0.8 to1 g has been administered. The usual dose for children is one-fourth of the adult dose of aurothioglucose, exceeding 25 mg per dose.
Which drugs or supplements interact with aurothioglucose?
The concurrent use of penicillamine (Cuprimine, Depen) and aurothioglucose should be avoided as the combination decreases the levels and efficacy of both drugs due to chelation (binding) of the gold salt to the penicillamine.
Is aurothioglucose safe to take if I'm pregnant or breastfeeding?
There are no adequate and well-controlled studies in pregnant women. Aurothioglucose should be used during pregnancy only if the potential benefit to the mother justifies the potential risk to the fetus.
Aurothioglucose has been found in the breast milk of women. Due to the potential for serious adverse reactions in nursing infants, decisions should be made whether to discontinue nursing or to discontinue the drug.
What else should I know about aurothioglucose?
What preparations of aurothioglucose are available?
Injectable suspension: 50 mg/ml.
How should I keep aurothioglucose stored?
Aurothioglucose should be stored at room temperature between 59 F and 86 F (15 C-30 C) away from light and moisture and should not be frozen.
Aurothioglucose (Solganal) is a medications prescribed for the treatment of rheumatoid arthritis, juvenile rheumatoid arthritis, and Felty's syndrome. Side effects, drug interactions, warnings and precautions, and patient information should be reviewed prior to taking any medication.
Related Disease Conditions
Rheumatoid Arthritis (RA)
Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints, the tissue around the joints, as well as other organs in the body. Early RA signs and symptoms include anemia, both sides of the body affected (symmetric), depression, fatigue, fever, joint deformity, joint pain, joint redness, joint stiffness, joint swelling, joint tenderness, joint warmth, limping, loss of joint function, loss of joint range of motion, and polyarthritis.
Arthritis (Joint Inflammation)
Arthritis is inflammation of one or more joints. When joints are inflamed they can develop stiffness, warmth, swelling, redness and pain. There are over 100 types of arthritis, including osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, lupus, gout, and pseudogout.
Psoriatic arthritis is a disease that causes skin and joint inflammation. Symptoms and signs include painful, stiff, and swollen joints, tendinitis, and organ inflammation. Treatment involves anti-inflammatory medications and exercise.
Juvenile Rheumatoid Arthritis (JRA)
Juvenile rheumatoid arthritis (JRA) annually affects one child in every thousand. There are six types of JRA. Treatment of juvenile arthritis depends upon the type the child has and should focus on treating the symptoms that manifest.
Felty's syndrome is a complication of long-term rheumatoid arthritis. Felty's syndrome is defined by the presence of three conditions: rheumatoid arthritis, an enlarged spleen, and an abnormally low white blood count. Treatment of Felty's syndrome is not always required; however, treatment for patients with infections is available.
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