What is auranofin, and how does it work (mechanism of action)?
Auranofin is an oral, gold-containing chemical (salt) used for treating rheumatoid arthritis. Other gold salts available are injectable and include aurothioglucose (Solganal) and gold sodium thiomalate (Myochrysine). It is not well understood exactly how gold salts work. In patients with inflammatory arthritis, such as adult and juvenile rheumatoid arthritis, gold salts decrease the inflammation of the lining of the joint. They prevent the inflammation from destroying the bone and cartilage surrounding the joint and deformities of the joints. Because of its ability to prevent or slow deformities of the joints, auranofin is considered a disease modifying anti-rheumatic drug (DMARD). Gold salts also are called second-line drugs because they often are considered when arthritis persists in spite of the use of antiinflammatory drugs (NSAIDs and corticosteroids). The term second-line is misleading since anti-inflammatory drugs and DMARDs have different mechanisms of action and in general are used together for their additive effects. DMARDs may take weeks to months to become effective. Auranofin was FDA approved in May 1985.
What are the side effects of auranofin?
The most common side effects of auranofin are:
An itching sensation can be an early warning sign of a skin reaction, such as a rash. Auranofin also can cause a metallic taste and mouth sores, though less frequently than injectable gold salts. Because gold salts can cause serious kidney and bone marrow problems, all patients require monitoring with regular testing of blood and urine. Hair loss, anemia, and reduced number of white blood cells or platelets have also been reported.
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- What is auranofin, and how does it work (mechanism of action)?
- What brand names are available for auranofin?
- Is auranofin available as a generic drug?
- Do I need a prescription for auranofin?
- What are the side effects of auranofin?
- What is the dosage for auranofin?
- Which drugs or supplements interact with auranofin?
- Is auranofin safe to take if I'm pregnant or breastfeeding?
- What else should I know about auranofin?
What is the dosage for auranofin?
The usual adult dosage of auranofin is 3 mg twice daily or 6 mg once a day. The dose may be increased to 3 mg three times daily after three months.
Which drugs or supplements interact with auranofin?
The concurrent use of auranofin and phenytoin (Dilantin), an antiepileptic drug, may increase phenytoin blood levels, which may lead to phenytoin toxicity for unclear reasons. The concurrent use of penicillamine (Cuprimine, Depen) and gold salts may result in blood cell or kidney toxicity since both drugs are toxic to the blood cells and kidney. The auranofin should not be used with atovaquone/proguanil (Malarone) an antimalarial drug, as the combination may increase the risk of toxicity to blood cells.
Is auranofin safe to take if I'm pregnant or breastfeeding?
There are no adequate studies in pregnant women. Use of auranofin in pregnant women is not recommended.
Auranofin has been found in the breast milk of nursing mothers. Nursing during auranofin therapy is not recommended.
Auranofin (Ridaura) is a gold-containing chemical (salt) prescribed for the treatment of rheumatoid arthritis, juvenile rheumatoid arthritis, psoriatic arthritis, and Felty's syndrome. Side effects, warnings and precautions, drug interactions, patient information should be reviewed prior to taking any medication.
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