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- What is attapulgite, and how does it work (mechanism of action)?
- What are the side effects of attapulgite?
- What is the dosage for attapulgite?
- Which drugs or supplements interact with attapulgite?
- Is attapulgite safe to take if I'm pregnant or breastfeeding?
- What else should I know about attapulgite?
What is attapulgite, and how does it work (mechanism of action)?
Attapulgite is an oral, nonabsorbed medication that is used in the management of diarrhea. It works by adsorbing (binding) large numbers of bacteria and toxins and reducing the loss of water. Attapulgite reduces the number of bowel movements, improves the consistency of loose or watery stools, and relieves the gastrointestinal cramping that often is associated with diarrhea.
Is attapulgite available as a generic drug?
Do I need a prescription for attapulgite?
What are the side effects of attapulgite?
Constipation is the main side effect of attapulgite. It can also cause:
What is the dosage for attapulgite?
Attapulgite is taken after each loose bowel movement.
- Adults and adolescents over the age of 12 years may take 1.2 to 1.5 grams per dose, up to 8.4 grams per day.
- Children 6 to 12 years of age may take 600 to 750 mg after each loose bowel movement and up to 4.5 grams per day.
- Children 3 to 6 years of age may take 300 mg after each loose bowel movement up to a total of 2.1 grams (7 doses) per day.
Which drugs or supplements interact with attapulgite?
Attapulgite can decrease the absorption of benztropine (Cogentin), trihexyphenidyl (Artane), loxapine (Loxitane) and dicyclomine (Bentyl) if taken at the same time. These medications should be taken at least 2 hours earlier or later than attapulgite. Attapulgite and other antidiarrheals can worsen constipation caused by opiate pain relievers such as oxycodone (Percocet), hydrocodone (Vicodin), propoxyphene (Darvon), morphine, and codeine.
Is attapulgite safe to take if I'm pregnant or breastfeeding?
Attapulgite is safe during pregnancy.
Attapulgite is safe to use in nursing mothers.
What else should I know about attapulgite?
What preparations of attapulgite are available?
Suspension: 600 mg/15ml or 750 mg/ml
How should I keep attapulgite stored?
Preparations should be stored at room temperature, 15 C - 30 C (59 F - 86 F).
Attapulgite (Rheaban; Kaopectate Advanced Formula; Parepectolin; Diasorb; Diatrol; Donnagel) is a medication prescribed for the short-term treatment of diarrhea. Side effects, drug interactions, and pregnancy safety should be reviewed prior to using.
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Travelers should prepare for their trip by visiting their physician to get the proper vaccinations and obtain the necessary medication if they have a medical condition or chronic disease. Diseases that travelers may pick up from contaminated water or food, insect or animal bites, or from other people include: malaria, meningococcal meningitis, yellow fever, hepatitis A, typhoid fever, polio, and cholera.
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Travelers' diarrhea is generally contracted by eating contaminated food or drinking contaminated water. Food is the primary source of travelers' diarrhea. Enterotoxigenic E. coli is the cause of up to 70% of all cases of travelers' diarrhea. There are five unique classes of E. coli that causes gastroenteritis. Other bacteria responsible for travelers' diarrhea include Campylobacter, jejuni, shigella, and salmonella. Viruses such as rotavirus and Norwalk virus (norovirus) and giardia lamblia a parasite may cause travelers' diarrhea. Prevention is careful eating and drinking of water.
IBS-D (Irritable Bowel Syndrome with Diarrhea)
IBS-D or irritable bowel syndrome with diarrhea refers to IBS with diarrhea. Symptoms of IBS-D include intestinal gas (flatulence), loose stools, frequent stools, abdominal pain, diarrhea, and nausea. New non-FDA approved IBS tests may help diagnose IBS and IBS-D. Treatment of IBS-D is geared to toward managing symptoms with diet, medication, and lifestyle changes.
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