Generic drug: atropine
Brand name: Atropen
What is Atropen (atropine), and how does it work?
Atropen (atropine) is a prescription medicine used to treat the symptoms of Anesthesia Premedication, Sinus Bradycardia (ACLS), Bronchospasm, and Organophosphate or Carbamate Poisoning. Atropen may be used alone or with other medications.
Atropen belongs to a class of drugs called Anesthetic Premedication Agents; Cholinergic, Toxicity Antidotes.
What are the side effects of Atropen?
Atropen may cause serious side effects including:
- coordination difficulties,
- loss of muscle control on one side,
- sensation loss on one side of the face,
- difficulty speaking,
- vomiting, and
- cardiac arrest
Get medical help right away, if you have any of the symptoms listed above.
The most common side effects of Atropen include:
- pain at the injection site,
- dry mouth,
- blurred vision,
- sensitivity to light,
- rapid or irregular heart rate,
- urinary problems,
- loss of sex drive,
- heat intolerance, and
- skin rash
Tell the doctor if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of Atropen. For more information, ask your doctor or pharmacist.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
FOR USE IN NERVE AGENT AND INSECTICIDE POISONING ONLY
CAUTION! PRIMARY PROTECTION AGAINST EXPOSURE TO CHEMICAL NERVE AGENTS AND INSECTICIDE POISONING IS THE WEARING OF PROTECTIVE GARMENTS INCLUDING MASKS DESIGNED SPECIFICALLY FOR THIS USE.
INDIVIDUALS SHOULD NOT RELY SOLELY UPON ANTIDOTES SUCH AS ATROPINE AND PRALIDOXIME TO PROVIDE COMPLETE PROTECTION FROM CHEMICAL NERVE AGENTS AND INSECTICIDE POISONING.
SEEK IMMEDIATE MEDICAL ATTENTION AFTER INJECTION WITH Atropen (atropine) .
A STERILE SOLUTION FOR INTRAMUSCULAR USE ONLY
What is the dosage for Atropen?
Important Administration Information
- It is recommended that three Atropen autoinjectors be available for use in each patient at risk for organophosphorus or carbamate poisoning; one (1) for mild symptoms plus two (2) more for severe symptoms. Different dose strengths of Atropen are available depending on the patient's weight.
- Atropen should be used by persons who have had adequate training in the recognition and treatment of nerve agent or insecticide intoxication, but may be administered by a caregiver or self-administration if a trained provider is not available.
- Only administer Atropen to patients experiencing symptoms of organophosphorus or carbamate poisoning in a situation where exposure is known or suspected. Atropen is a single-dose autoinjector intended as an initial treatment of the muscarinic symptoms of insecticide or nerve agent poisonings (generally breathing difficulties due to increased secretions); definitive medical care should be sought immediately.
- Atropen should be administered as soon as symptoms of organophosphorus or carbamate poisoning appear.
- In severe poisonings, it may also be desirable to concurrently administer an anticonvulsant (preferably a benzodiazepine) if seizure is suspected in the unconscious individual since the classic tonic-clonic jerking may not be apparent due to the effects of the poison.
- A cholinesterase reactivator such as pralidoxime may serve as an important adjunct to atropine therapy.
- Close supervision of all treated patients is indicated for at least 48 to 72 hours.
- Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
Different dose strengths of Atropen are available depending on the patient's age and weight (see Table 1).
Table 1: Recommended Dose Strength per Atropen Injection
|Age and Body Weight||Strength of each Atropen Injection|
|Adults and pediatric patients weighing over 41 kg (90 pounds) (generally over 10 years of age)||Atropen 2 mg (green label)|
|Pediatric patients weighing 18 kg to 41 kg (40 pounds to 90 pounds) (generally 4 to 10 years of age)||Atropen 1 mg (red label)|
|Pediatric patients weighing 7 kg to 18 kg (15 pounds to 40 pounds) (generally 6 months to 4 years of age)||Atropen 0.5 mg (blue label)|
|Pediatric patients weighing less than 7 kg (15 pounds) (generally less than 6 months of age)||Atropen 0.25 mg (yellow label)|
Dosage For Mild Symptoms
- If the patient experiences two or more mild symptoms of nerve agent or insecticide exposure listed in Table 2, administer one (1) Atropen injection intramuscularly into the mid-lateral (outer) thigh.
- If, at any time after receiving the first Atropen injection, the patient has any of the severe symptoms listed in Table 2, administer two (2) additional Atropen injections in rapid succession. If possible, a person other than the patient should administer the second and third Atropen injections.
- Wait 10 to 15 minutes for Atropen to take effect. If after 10 to 15 minutes, the patient does not develop any of the severe symptoms listed in Table 2, no additional Atropen injections are recommended.
Dosage For Severe Symptoms
- If the patient is either unconscious or has any of the severe symptoms listed in Table 2, immediately administer three (3) Atropen injections intramuscularly into the patient's mid-lateral thigh in rapid succession.
Table 2: Common Symptoms of Organophosphorus or Carbamate Poisoning
|Mild Symptoms||Severe Symptoms|
|* These symptoms are sometimes observed in healthy infants and young children. In this age group, these symptoms are less reliable than other symptoms listed. Symptoms must be considered collectively when nerve agent or pesticide exposure is known or suspected.
** Infants may become drowsy or unconscious, with muscle floppiness rather than muscle twitching, soon after exposure to nerve agents or insecticides.
What drugs interact with Atropen?
When atropine and pralidoxime are used together, the signs of atropinization (flushing, mydriasis, tachycardia, dryness of the mouth and nose) may occur earlier than might be expected when atropine is used alone because pralidoxime may potentiate the effect of atropine. Excitement and manic behavior immediately following recovery of consciousness have been reported in several cases. However, similar behavior has occurred in cases of organophosphate poisoning that were not treated with pralidoxime.
Barbiturates are potentiated by the anticholinesterases; therefore, barbiturates should be used cautiously in the treatment of convulsions resulting from exposure to atropine.
Is Atropen safe to use while pregnant or breastfeeding?
- It is not known whether atropine can cause fetal harm when administered to a pregnant woman or if these agents can affect reproductive capacity.
- Atropine should be administered to a pregnant woman only if clearly needed.
- Atropine is found in human milk in trace amounts.
- Caution should be exercised when atropine is administered to a nursing woman.
Latest Medications News
Daily Health News
Atropen (atropine) is a prescription medicine used to treat the symptoms of Anesthesia Premedication, Sinus Bradycardia (ACLS), Bronchospasm, and Organophosphate or Carbamate Poisoning. Atropen may be used alone or with other medications. Serious side effects of Atropen include restlessness, tremor, fatigue, coordination difficulties, confusion, hallucinations, depression, loss of muscle control on one side, sensation loss on one side of the face, nausea, difficulty speaking, vomiting, and cardiac arrest.
Multimedia: Slideshows, Images & Quizzes
Related Disease Conditions
Ricin is a biological toxin that can be made from processing castor beans. The length of time it takes for the poison to begin working depends on if you inhaled or ingested it, or if your skin and eyes were exposed. However, generally symptoms begin a few hours after poisoning; typically less than 10. You can die from ricin poisoning between 36 and 72 hours after exposure. Symptoms of ricin poisoning include: Fever Cough Nausea Low blood pressure Diarrhea Seizures Blood in the urine As there is no antidote, treatment focuses on minimizing the effects of poisoning.
How Long Does It Take to Get Lead Poisoning?
Lead poisoning usually takes months or years of exposure to a small amount of lead at home, work or daycare. When exposed to large amounts of lead, it can quickly lead to lead poisoning (acute poisoning).
Second Source article from Government
Arsenic comes in two forms, inorganic and organic. Organic arsenic poisoning is usually not poisonous to humans; however, inorganic arsenic in large enough amounts can lead to shock and death. Symptoms of arsenic poisoning include nausea, abdominal pain, diarrhea, dehydration, dark urine, vertigo, delirium, shock, and death. Treatment for arsenic poisoning includes Hemodialysis and a variety of drugs.
Mercury is a naturally occurring element found in water, soil, and the air. Mercury also is contained in some fish, some of the products we use in the home, school, or dentist. Mercury poisoning can cause cognitive problems, dermatitis, tremor and other symptoms. Information about sources of mercury exposure, potential health effects, symptoms of exposure, fish that may contain mercury, consumer products that contain mercury, and ways to reduce your exposure to mercury is important for the health of you, and your family.
Ciguatera poisoning is a type of food poisoning caused by the ciguatera toxin found in a variety of large reef fish found between the Tropic of Cancer and the Tropic of Capricorn. Symptoms of ciguatera poisoning include diarrhea, nausea, vomiting, abdominal pain, dizziness, vertigo, numbness, tingling, and muscle pain. Ciguatera poisoning requires medical treatment.
What Happens When You Get Mercury Poisoning?
Exposure to high levels of mercury can harm the brain, heart, kidneys, lungs, and immune system of people of all ages. Very young children and unborn are the most susceptible to the effects of mercury. Although mercury is known to cause tumors in rats in the laboratory, there is insufficient proof to link mercury with cancers in humans.
Radon (A Citizen's Guide to Radon)
Radon is a radioactive gas that has been confirmed to cause cancers. About 21,000 individuals die each year due to radon exposure. Radon can be found in the ground, water supply, and the air you breathe. It is found in schools, homes, offices, and other buildings. You can purchase a Radon Test Kit and have the sample sent to the state radon office. Research has shown that the risk of lung cancer from breathing radon in air is much greater than the risk of stomach cancer from swallowing water with radon in it. The EPA offers a Consumers Guide to Radon Reduction so you can take action to reduce radon levels in your home, school, or office. Scientists are more certain about radon risks than from most other cancer-causing substances.
What Does Lead Poisoning Do To Adults?
Lead is a naturally occurring toxic metal found in the earth’s crust. Excess lead buildup in the body can cause lead poisoning. Although lead poisoning primarily affects children, it can also prove to be dangerous in adults.
Can Ricin Poisoning Cause Death?
Effects of ricin poisoning depend on whether ricin was inhaled, ingested, or injected. Ricin poisoning can eventually lead to multiple organ failure, leading to death within 36-72 hours of exposure, depending on the dosage of ricin and mode of exposure. There is no antidote for ricin; hence, ricin poisoning is mainly treated symptomatically with supportive medical care to reduce the effects of poisoning.
What Happens to Your Body When You Have Alcohol Poisoning?
Alcohol poisoning is the condition when alcohol reaches dangerous levels in your blood known as increased blood alcohol concentration (BAC). The more the BAC, the more is the effect of alcohol on your body. Alcohol poisoning usually occurs when you drink an excessive amount of alcohol quickly.
Treatment & Diagnosis
- Carbon Monoxide Poisoning - Danger In Winter Sports
- Poison - Severe Unexplained Illness Possibly a Result of Toxic Tea
- Anesthesia -- Women Wake Up Faster
- Poisoning: Handling a Poisoning Emergency
- Facts About Thallium Poisoning
- The Death of Joan Rivers: Endoscopy and Anesthesia Risks
- Should I Get Tested for Food Poisoning?
- Lead Poisoning - The Lead Story
- Lead Poisoning Symptoms
- Carbon Monoxide Poisoning Symptoms
Medications & Supplements
Prevention & Wellness
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.