atovaquone and proguanil (Malarone) oral

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

What is atovaquone-proguanil-oral, and how does it work (mechanism of action)?

Atovaquone and proguanil is an anti-malarial medication. Atovaquone blocks mitochondrial electron transfer and thereby the production of energy for use by the parasites. Proguanil is metabolized into its active metabolite, cycloguanil, which blocks dihydrofolate reductase and enzymes required for making pyrimidine which is a chemical needed for production of DNA.

What brand names are available for atovaquone-proguanil-oral?

Malarone

Is atovaquone-proguanil-oral available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for atovaquone-proguanil-oral?

Yes

What are the side effects of atovaquone-proguanil-oral?

Common side effects of atovaquone and proguanil are:

Quick GuideSymptoms of Mono: Infectious Mononucleosis Treatment

Symptoms of Mono: Infectious Mononucleosis Treatment

What is the dosage for atovaquone-proguanil-oral?

Prevention of malaria:

Which drugs or supplements interact with atovaquone-proguanil-oral?

Combining atovaquone/proguanil with tetracycline can lower atovaquone levels in the body, leading to lack of effectiveness of the antimalarial medication.

Concomitant use of atovaquone/proguanil and rifampin or rifabutin can lower atovaquone levels approximately 50% and 34%, reducing effectiveness of malarial medication.

Concomitant use of atovaquone/proguanil and metoclopramide (Reglan, Reglan ODT, Metozol ODT, Octamide) may lower the amount of atovaquone that the body can absorb, leading to lack of effectiveness.

Is atovaquone-proguanil-oral safe to take if I'm pregnant or breastfeeding?

There are no adequate studies of atovaquone and proguanil to determine safe and effective use in pregnant women.

It is not known if atovaquone enters breast milk, but proguanil may enter breast milk in trace amounts. It is best to exercise caution before using these drugs in nursing mothers.

What else should I know about atovaquone-proguanil-oral?

What preparations of atovaquone-proguanil-oral are available?

Atovaquone and proguanil tablets are available in two combination strengths: 250/100 mg (adults) and 62.5/25 mg (pediatric).

How should I keep atovaquone-proguanil-oral stored?

Store Atovaquone and proguanil tablets should be stored between 15 C to 30 C (59 F to 86 F).

REFERENCE: FDA Prescribing Information.

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Reviewed on 9/10/2015
References
REFERENCE: FDA Prescribing Information.

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