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- What is atovaquone-proguanil-oral, and how does it work (mechanism of action)?
- What brand names are available for atovaquone-proguanil-oral?
- Is atovaquone-proguanil-oral available as a generic drug?
- Do I need a prescription for atovaquone-proguanil-oral?
- What are the side effects of atovaquone-proguanil-oral?
- What is the dosage for atovaquone-proguanil-oral?
- Which drugs or supplements interact with atovaquone-proguanil-oral?
- Is atovaquone-proguanil-oral safe to take if I'm pregnant or breastfeeding?
- What else should I know about atovaquone-proguanil-oral?
What is atovaquone-proguanil-oral, and how does it work (mechanism of action)?
Atovaquone and proguanil is an anti-malarial medication. Atovaquone blocks mitochondrial electron transfer and thereby the production of energy for use by the parasites. Proguanil is metabolized into its active metabolite, cycloguanil, which blocks dihydrofolate reductase and enzymes required for making pyrimidine which is a chemical needed for production of DNA.
What are the side effects of atovaquone-proguanil-oral?
Common side effects of atovaquone and proguanil are:
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Which drugs or supplements interact with atovaquone-proguanil-oral?
Concomitant use of atovaquone/proguanil and rifampin or rifabutin can lower atovaquone levels approximately 50% and 34%, reducing effectiveness of malarial medication.
Is atovaquone-proguanil-oral safe to take if I'm pregnant or breastfeeding?
There are no adequate studies of atovaquone and proguanil to determine safe and effective use in pregnant women.
What else should I know about atovaquone-proguanil-oral?
What preparations of atovaquone-proguanil-oral are available?
Atovaquone and proguanil tablets are available in two combination strengths: 250/100 mg (adults) and 62.5/25 mg (pediatric).
How should I keep atovaquone-proguanil-oral stored?
Store Atovaquone and proguanil tablets should be stored between 15 C to 30 C (59 F to 86 F).
REFERENCE: FDA Prescribing Information.
Atovaquone and proguanil (Malarone) oral is a medication prescribed to treat and prevent malaria. Side effects, dosage, warnings and precautions, and pregnancy safety information should be reviewed prior to taking this medication.
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