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- What is atenolol and chlorthalidone, and how does it work (mechanism of action)?
- What brand names are available for atenolol and chlorthalidone?
- Is atenolol and chlorthalidone available as a generic drug?
- Do I need a prescription for atenolol and chlorthalidone?
- What are the side effects of atenolol and chlorthalidone?
- What is the dosage for atenolol and chlorthalidone?
- Which drugs or supplements interact with atenolol and chlorthalidone?
- Is atenolol and chlorthalidone safe to take if I'm pregnant or breastfeeding?
- What else should I know about atenolol and chlorthalidone?
What is atenolol and chlorthalidone, and how does it work (mechanism of action)?
Atenolol/chlorthalidone is a combination of atenolol (Tenormin) and chlorthalidone (Hygroton) used for the treatment of high blood pressure. Atenolol is a beta-adrenergic blocking agent that blocks the effects of adrenergic drugs, for example, adrenaline or epinephrine, on nerves of the sympathetic nervous system. Atenolol reduces the heart rate and is useful in treating abnormally rapid heart rhythms. Atenolol also reduces the force of contraction of heart muscle and lowers blood pressure. Chlorthalidone is a diuretic (water pill). It works by reducing the kidneys' ability to hold on to salt and water and increasing the kidneys' production of urine (diuresis). It is used to eliminate excess salt and water from the body and to treat high blood pressure. The FDA approved atenolol/chlorthalidone in June 1984.
What are the side effects of atenolol and chlorthalidone?
Side effects of Atenolol/chlorthalidone are similar to side effects form the individual components and are:
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What is the dosage for atenolol and chlorthalidone?
The recommended dose of atenolol/chlorthalidone is one tablet once daily starting with 50 mg/25 mg then increasing to 100 mg/25 mg if blood pressure control is not adequate.
Which drugs or supplements interact with atenolol and chlorthalidone?
- Chlorthalidone can lower blood potassium and magnesium levels because both potassium and magnesium are lost in the urine.
- Chlorthalidone reduces the kidney's ability to eliminate lithium (Lithobid) in the urine. As a result, patients taking chlorthalidone at the same time as drugs containing lithium may develop high levels of lithium and/or lithium toxicity.
- Atenolol can mask the early warning symptoms of low blood sugar (hypoglycemia), and should be used with caution in patients receiving treatment for diabetes. Combining atenolol with other drugs that reduce blood pressure or slow heart rate may lead to excessive blood pressure reduction or low heart rate.
Is atenolol and chlorthalidone safe to take if I'm pregnant or breastfeeding?
Atenolol is excreted in breast milk and may adversely affect the infant. Atenolol/chlorthalidone should be avoided while breastfeeding.
What else should I know about atenolol and chlorthalidone?
What preparations of atenolol and chlorthalidone are available?
Tablets: atenolol 50mg and chlorthalidone 25mg; atenolol 100mg and chlorthalidone 25mg.
How should I keep atenolol and chlorthalidone stored?
Tablets should be stored at room temperature, 15C and 30 C (59 F and 86 F).
Medically reviewed by John Cunha, DO
Reference: FDA Prescribing Information
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- atenolol and chlorthalidone, Tenoretic Related Diseases
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Reference: FDA Prescribing Information
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atenololAtenolol (Tenormin)is a beta-adrenergic blocking agent, blocking the action of the sympathetic nervous system, a portion of the involuntary nervous system. Atenolol is prescribed for patients with high blood pressure (hypertension), used to treat chest pain (angina pectoris) related to coronary artery disease, and is also useful in slowing and regulating certain types of abnormally rapid heart rates (tachycardias). Other uses for atenolol include the prevention of migraine headaches and the treatment of certain types of tremors (familial or hereditary essential tremors). It is important to be aware of the drug interactions related to atenolol, effects on pregnancy, as well as common side effects on the user.
Beta blockers are a class of drugs that block beta-adrenergic substances such as adrenaline (epinephrine), a key agent in the "sympathetic" portion of the autonomic (involuntary) nervous system and activation of heart muscle. By blocking the action of the involuntary nervous system on the heart, beta blockers relieve stress on the heart.
Beta blockers are used for the treatment of irregular heart rhythms, chest pain, heart attack, hypertension, migraine headaches, social phobias, tremors, and glaucoma.
Common side effects of beta blockers are nausea, vomiting, abdominal cramps, diarrhea, and weight gain if you are taking medicine for diabetes (type 1 and type 2). There are other important side effects and serious adverse effects of this drug class that include, blurred vision, insomnia, hair loss, disorientation, CNS system effects, and serious heart problems.
Beta blockers interact with several other drugs, for example, chlorpromazine (Thorazine), clonidine (Catapres), Phenobarbital, nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin, and diabetes medications, including insulin.
Examples of generic and brand names available for beta blockers in the US include acebutolol (Sectral), atenolol (Tenormin), bisoprolol (Zebeta), metoprolol (Lopressor, Lopressor LA, Toprol XL), nadolol (Corgard), timolol (Blocadren). Talk with your doctor, pharmacist, or other medical professional if you have questions about beta-blockers.
If you notice other effects not listed above, contact your doctor or pharmacist. In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
chlorthalidoneChlorthalidone (Thalitone [Hygroton discontinued brand in USA]) is a medication prescribed for the treatment of high blood pressure, congestive heart failure, and edema. Side effects, drug interactions, dosing information, and pregnancy safety should be reviewed prior to taking any medication.
Drug InteractionsDrug interactions occur frequently. Get facts about the types of drug interactions, what substances or other things that may interact with drugs such as OTC drug and prescription drugs, vitamins, food(s) (grapefruit), and laboratory tests. Find out how to protect yourself from potential drug interactions.
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High Blood Pressure HypertensionHigh blood pressure is defined as a pressure of 140/90 mmHg or higher in the arteries. Genetic factors, high salt intake, and increased arterial stiffness cause high blood pressure. Dizziness, headache, nausea, and shortness of breath are just a few symptoms of high blood pressure. Untreated high blood pressure increases the risk of heart disease, kidney disease, atherosclerosis, eye damage, stroke, and increased risk of aneurysms. High blood pressure can be managed with weight loss, lifestyle changes, and medication.
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Migraine headaches are severe headaches that are sensitive to light, sounds, and smells. Some people who suffer from migraines also have severe head pain. People also have symptoms of nausea and vomiting. Common migraine triggers may include:
- Certain foods
- Changes in barometric pressure
- Other phenomenon
They are diagnosed by a doctor if the headache pattern fits established migraine headache criteria. Over-the-counter (OTC) and prescription medications are sometime used to treat acute migraines. To prevent or reduce the frequency and severity of them doctors recommend supplements and prescription medications, for example:
- Blood pressure drugs
- Anti-seizure drugs
Lifestyle modification helps in migraine management. Many people who suffer from migraines get relief from their condition by keeping a headache diary, identifying and avoiding triggers, and taking appropriate medication.
Side Effects and Adverse Effects of Beta Blockers
Beta blockers (beta-adrenergic blocking agents) is a class of drugs that block norepinephrine and adrenaline from binding to beta receptors on nerves. Beta blockers inhibit (block) these two hormones, thereby reducing heart rate and blood vessels. There are a variety of drugs in this class, for example, atenolol (Tenormin), carvedilol (Coreg), and metoprolol (Lopressor, Toprol XL).
Common side effects of these drugs include:
- Stomach cramps
Other important side effects include:
- Blurred vision
- Hair Loss
These drugs also cause central nervous system (CNS) effects like:
Other serious side effects of beta-blockers include:
- Lupus erythematous
- Serious allergic reactions
- Erythema multiform
- Steven Johnson Syndrome
- Toxic epidermal necrolysis