- What other names is Ascorbigen known by?
- What is Ascorbigen?
- How does Ascorbigen work?
- Are there safety concerns?
- Are there any interactions with medications?
- Dosing considerations for Ascorbigen.
AGN, Ascrobigène, Indole.
Ascorbigen is a chemical found in broccoli, cauliflower, cabbage, and related vegetables. It is used to make medicine.
Insufficient Evidence to Rate Effectiveness for...
- Fibromyalgia. Developing research suggests that ascorbigen and broccoli powder might reduce pain and other symptoms in people with fibromyalgia.
- Breast cancer.
- Other conditions.
There isn't enough information available to know how ascorbigen might work.
Special Precautions & Warnings:Pregnancy and breast-feeding: Not enough is known about the use of ascorbigen during pregnancy and breast-feeding. Stay on the safe side and avoid use.
Medications changed by the liver (Cytochrome P450 1A2 [CYP1A2] substrates)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Some medications are changed and broken down by the liver. Ascorbigen might increase how quickly the liver breaks down some medications. Taking ascorbigen along with some medications that are changed by the liver might decrease the effects of some medications.
Some of these medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others.
The appropriate dose of ascorbigen depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for ascorbigen. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).
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Bonnesen C, Eggleston IM, Hayes JD. Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines. Cancer Res 2001;61:6120-30. View abstract.
Bramwell B, Ferguson S, Scarlett N, Macintosh A. The use of ascorbigen in the treatment of fibromyalgia patients: a preliminary trial. Altern Med Rev 2000;5:455-62. View abstract.
Buskov S, Hansen LB, Olsen CE, et al. Determination of ascorbigens in autolysates of various Brassica species using supercritical fluid chromatography. J Agric Food Chem 2000;48:2693-701. View abstract.
Kravchenko LV, Avren'eva LI, Guseva GV, et al. Effect of nutritional indoles on activity of xenobiotic metabolism enzymes and T-2 toxicity in rats. Bull Exp Biol Med 2001;131:544-7. View abstract.
Sepkovic DW, Bradlow HL, Michnovicz J, et al. Catechol estrogen production in rat microsomes after treatment with indole-3-carbinol, ascorbigen, or beta-naphthaflavone: a comparison of stable isotope dilution gas chromatography-mass spectrometry and radiometric methods. Steroids 1994;59:318-23. View abstract.