- Causes of Fatigue Slideshow Pictures
- Sleep Quiz: Test Your Medical IQ
- Sleep Slideshow: Foods That Help or Harm Your Sleep
- What is armodafinil, and how does it work (mechanism of action)?
- What brand names are available for armodafinil?
- Is armodafinil available as a generic drug?
- Do I need a prescription for armodafinil?
- What are the side effects of armodafinil?
- What is the dosage for armodafinil?
- Which drugs or supplements interact with armodafinil?
- Is armodafinil safe to take if I'm pregnant or breastfeeding?
- What else should I know about armodafinil?
What is armodafinil, and how does it work (mechanism of action)?
Armodafinil is an oral drug that is used to promote wakefulness. It is similar to modafinil (Provigil). Like amphetamines, armodafinil promotes wakefulness by stimuatIng the brain; however, the exact mechanism of action of armodafinil is unknown. Armodafinil may work by increasing the amount of dopamine (a chemical neurotransmitter that nerves use to communicate with each other) in the brain by reducing the reuptake of dopamine into nerves. The FDA approved armodafinil in June 2007.
What are the side effects of armodafinil?
Headache is the most common side effect of armodafinil. Other side effects include:
Quick GuideSleep Disorders: Insomnia, Sleep Apnea, and More
What is the dosage for armodafinil?
The recommended dose is 150 or 250 mg every morning or 150 mg daily one hour prior to the work shift.
Which drugs or supplements interact with armodafinil?
Armodafinil can decrease or increase the activity of enzymes in the liver that metabolize (eliminate) other drugs. This can result in decreased levels of some drugs that reduce their effectiveness as well as increased levels of other drugs that increase their toxicity. Armodafinil treatment should be carefully monitored if taken with any of these drugs.
Drugs which may have reduced effectiveness if taken with armodafinil include cyclosporine (Sandimmune), ethinyl estradiol (Estrace, Climara, Estraderm, Menostar) (present in many birth control pills), midazolam (Versed), and triazolam (Halcion).
Drugs that may show increased effects or toxicity if taken with armodafinil include omeprazole (Prilosec), warfarin (Coumadin), diazepam (Valium), propranolol (Inderal), imipramine (Tofranil), desipramine (Norpramin), clomipramine (Anafranil), phenytoin (Dilantin) and mephenytoin (Mesantoin).
Carbamazepine (Tegretol), phenobarbital, and rifampin (Rifadin) may reduce the action of armodafinil by increasing armodafinil's elimination by the liver. Ketoconazole (Nizoral), itraconazole (Sporanox) and erythromycin may increase the effectiveness of armodafinil by reducing the elimination of armodafinil by the liver.
Is armodafinil safe to take if I'm pregnant or breastfeeding?
It is not known whether armodafinil is secreted in breast milk.
What else should I know about armodafinil?
What preparations of armodafinil are available?
PREPARATIONS: Tablets: 50, 150, 250 mg.
How should I keep armodafinil stored?
Armodafinil should be stored at room temperature, 20-30 C (68-77 F).
Reference: FDA Prescribing Information for Nuvigil
Quick GuideSleep Disorders: Insomnia, Sleep Apnea, and More
Armodafinil (Nuvigil) is a drug prescribed to promote wakefulness associated with narcolepsy, obstructive sleep apnea/hypoapnea syndrome, and shift work sleep disorder. Side effects, drug interactions, and warnings and precautions should be reviewed prior to taking any medication.
Related Disease Conditions
Multiple Sclerosis Symptoms (Early, Body Areas Affected)
Multiple sclerosis (MS) symptoms vary from person to person, and can last for days to months without periods of remission....
Sleep apnea is defined as a reduction or cessation of breathing during sleep. The three types of sleep apnea are central apnea,...
Narcolepsy (Definition, Symptoms, Treatment, Medication)
Causes of narcolepsy, a chronic disease of the central nervous system, have not been fully determined. Some theories include...
Insomnia Treatment (Sleep Aids and Stimulants)
Insomnia is difficulty in falling or staying asleep, the absence of restful sleep, or poor quality of sleep. Insomnia is a...
Treatment & Diagnosis
Prevention & Wellness
Daily Health News
Subscribe to MedicineNet's Depression Newsletter
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Top armodafinil Related ArticlesComplete List
MS (Multiple Sclerosis) Symptoms and Treatments
Multiple sclerosis (MS) symptoms vary from person to person, and can last for days to months without periods of remission. Symptoms of MS include problems with the:
- Eyes (vision)
- Brain and nervous system
- Sexual problems
Treatment options vary depending on the type and severity of symptoms. Medications may be prescribed to manage MS symptoms.
NarcolepsyCauses of narcolepsy, a chronic disease of the central nervous system, have not been fully determined. Some theories include abnormalities in hypocretin neurons in the brain or an autoimmune disorder. Symptoms of narcolepsy include:
- excessive daytime sleepiness,
- hypnagogic hallucinations,
- sleep paralysis,
- disturbed nocturnal sleep, and
- automatic behavior.
Diagnosis of narcolepsy is based on a clinical evaluation, specific questionnaires, sleep logs or diaries, and the results of sleep laboratory tests. Treatments of narcolepsy symptoms include medication and lifestyle changes.
Sleep Aids And StimulantsInsomnia is difficulty in falling or staying asleep, the absence of restful sleep, or poor quality of sleep. Insomnia is a symptom and not a disease. The most common causes of insomnia are medications, psychological conditions, environmental changes and stressful events. Treatments may include non-drug treatments, over-the-counter medicines, and/or prescription medications.
Sleep ApneaSleep apnea is defined as a reduction or cessation of breathing during sleep. The three types of sleep apnea are central apnea, obstructive apnea (OSA), and a mixture of central and obstructive apnea. Central sleep apnea is caused by a failure of the brain to activate the muscles of breathing during sleep. OSA is caused by the collapse of the airway during sleep. OSA is diagnosed and evaluated through patient history, physical examination and polysomnography. There are many complications related to obstructive sleep apnea. Treatments are surgical and non-surgical.