- Side Effects
- Drug Interactions
- Pregnancy & Breastfeeding
- What Else to Know
Generic Name: apixaban
Brand Name: Eliquis
What is apixaban, and what is it used for?
Apixaban is an anticoagulant (blood thinner) used for reducing the risk of blood clots in the heart and strokes in patients with atrial fibrillation who have no problems with their heart valves (nonvalvular atrial fibrillation). Apixaban is also used to treat and prevent deep vein thrombosis (DVT) and pulmonary embolism (PE) in patients who have undergone hip or knee replacement surgery.
- Apixaban is used for reducing the risk of blood clots in the heart and strokes in patients with atrial fibrillation who have no problems with their heart valves (nonvalvular atrial fibrillation).
- It also is used for treating and preventing deep venous thrombosis (DVT) and pulmonary embolism in patients who have undergone hip or knee replacement surgery.
What are the side effects of apixaban?
The most common side effects of apixaban involves bleeding in the:
- brain, and
Bleeding due to apixaban may be fatal.
What is the dosage for apixaban?
- The usual dose in nonvalvular atrial fibrillation is 5 mg by mouth twice daily. For individuals 80 years or older, weighing less than or equal to 60 kg, or with reduced kidney function, the usual dose is 2.5 mg twice daily.
- The recommended dose for treating DVT or pulmonary embolism is 10 mg twice daily for the first 7 days and then 5 mg twice daily. After six months of treatment, the dose may be reduced to 2.5 mg daily for prevention of DVT or pulmonary embolism.
- When apixaban is used to prevent the risk of DVT after hip or knee replacement surgery, the suggested dose is 2.5 mg daily beginning 12 to 24 hours after the surgery is completed.
What drugs interact with apixaban?
Apixaban is a blood thinner medicine that reduces blood clotting. You may have a higher risk of bleeding if you take apixaban and take other medicines that increase your risk of bleeding, including:
- aspirin or aspirin-containing products
- long-term (chronic) use of nonsteroidal anti-inflammatory drugs (NSAIDs)
- warfarin (Jantoven)
- any medicine that contains heparin
- selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs)
- other medicines to help prevent or treat blood clots
Tell your doctor if you take any of these medicines. Many other drugs may interact with apixaban, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here. Tell your doctor, dentist, and pharmacist of all drugs and supplements you take.
Spinal or epidural blood clots (hematoma)
People who take a blood thinner medicine (anticoagulant) like apixaban, and have medicine injected into their spinal and epidural area, or have a spinal puncture have a risk of forming a blood clot that can cause long-term or permanent loss of the ability to move (paralysis). Your risk of developing a spinal or epidural blood clot is higher if:
- a thin tube called an epidural catheter is placed in your back to give you certain medicine
- you take NSAIDs or a medicine to prevent blood from clotting
- you have a history of difficult or repeated epidural or spinal punctures
- you have a history of problems with your spine or have had surgery on your spine
If you take apixaban and receive spinal anesthesia or have a spinal puncture, your doctor should watch you closely for symptoms of spinal or epidural blood clots or bleeding. Tell your doctor right away if you have tingling, numbness, or muscle weakness, especially in your legs and feet.
Pregnancy and breastfeeding
- There are no adequate studies in pregnant women. Use during pregnancy may increase the risk of bleeding during pregnancy and delivery. Apixaban should be avoided during pregnancy.
- It is not known if apixaban is excreted in human milk. Nursing mothers should discontinue apixaban or discontinue nursing.
Apixaban is a medication prescribed to prevent blood clots in the heart and strokes in patients with atrial fibrillation, and to prevent and treat deep vein thrombosis and pulmonary embolism. The most common side effects of apixaban involves bleeding in the stomach, intestines, brain, and eyes. Bleeding due to apixaban may be fatal.
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Blood clots can form in the heart, legs, arteries, veins, bladder, urinary tract, and uterus. Risk factors include high blood pressure and cholesterol, diabetes, smoking, and family history. Symptoms and treatment depend on the location of the clot.
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Atrial Fibrillation (AFib) Symptoms and Signs
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Medications & Supplements
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.