Apathy refers to a lack of interest or concern about a situation or event that would typically elicit emotion. Apathy in certain circumstances can be a personality trait, but unusual or extreme apathy can be a symptom of mental or emotional conditions, including major depression, dementia, and schizophrenia. In its extreme form, apathy may be referred to as a flat affect, in which a person does not show normal emotional responses.
Apathy can be associated with other symptoms including
- social withdrawal,
- anxiety,
- loss of interest in everyday activities, or
- mood changes.
Apathy can also arise as a result of physical illnesses or medications in some cases.
Other causes of apathy
- Alcohol or Drug Intoxication
- Cyclothymic Disorder
- Delusional Disorder
- Paraphrenia
- Psychosis
- Schizophreniform Disorder

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Causes of Apathy
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Alzheimer's Disease
Alzheimer's disease is a common cause of dementia. Symptoms and warning signs of Alzheimer's disease include memory loss, difficulty performing familiar tasks, disorientation to time and place, misplacing things, and more. The biggest risk factor for Alzheimer's disease is increased age. Treatment for Alzheimer's is often targeted toward decreasing the symptoms and progression of the disease.
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Bipolar Disorder in Children, Teens, and Adults
Bipolar disorder (or manic depression) is a mental illness characterized by depression, mania, and severe mood swings. Treatment may incorporate mood-stabilizer medications, antidepressants, and psychotherapy.
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Dementia
Dementia is defined as a significant loss of intellectual abilities such as memory capacity, severe enough to interfere with social or occupational functioning. There are several different types of dementia, including cortical, subcortical, progressive, primary, and secondary dementias. Other conditions and medication reactions can also cause dementia. Dementia is diagnosed based on a certain set of criteria. Treatment for dementia is generally focused on the symptoms of the disease.
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Depression
Depression is an illness that involves the body, mood, and thoughts and affects the way a person eats and sleeps, the way one feels about oneself, and the way one thinks about things. The principal types of depression are major depression, dysthymia, and bipolar disease (also called manic-depressive disease).
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Drug Abuse and Addiction
Drug abuse and addiction is a chronic disease that causes drug-seeking behavior and drug use despite negative consequences to the user and those around him. Though the initial decision to use drugs is voluntary, changes in the brain caused by repeated drug abuse can affect a person's self-control and ability to make the right decisions and increase the urge to take drugs. Drug abuse and addiction are preventable.
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Dysthymia
Dysthymia is a less severe form of chronic depression. Symptoms and signs include insomnia, suicidal thoughts, guilt, empty feeling, loss of energy, helplessness, sluggishness, and persistent aches and pains. Treatment may involve psychotherapy, electroconvulsive therapy, and antidepressants.
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Encephalitis
Encephalitis is a brain inflammation that causes sudden fever, vomiting, headache, light sensitivity, stiff neck and back, drowsiness, and irritability. Treatment may incorporate anticonvulsants and antiviral medications.
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Grief and Mourning
Grief is the feeling one experiences after a loss (of a friendship, death of a loved one, job). Complicated grief refers to grief that lasts for more than a year. Mourning describes the customs and rituals that help bereaved individuals make sense of their loss.
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Head Injury (Brain Injury)
In the United States, head injuries are one of the most common causes of death and disability. Head injuries due to bleeding are generally classified by the location of the blood within the skull, these include epidural hematoma, subdural hematoma, subarachnoid bleed, intracranial bleed, sheer injury, edema, and skull fracture. Some common symptoms of a head injury include vomiting, bleeding from the ear, speech difficulties, paralysis, difficulty swallowing, and body numbness. Treatment of a head injury depends on the type and severity of the injury.
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Parkinson's Disease
Parkinson's disease is a slowly progressive neurological disease characterized by a fixed inexpressive face, a tremor at rest, slowing of voluntary movements, a gait with short accelerating steps, peculiar posture and muscle weakness, caused by degeneration of an area of the brain called the basal ganglia, and by low production of the neurotransmitter dopamine. Most patients are over 50, but at least 10 percent are under 40.
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Postpartum Depression
Postpartum depression is a form of depression that occurs within a year after delivery. It is thought that rapid hormone changes after childbirth may lead to depression. Symptoms of postpartum depression include crying a lot, headaches, chest pains, eating too little or too much, sleeping too little or too much, withdrawal from friends and family, and feeling irritable, sad, hopeless, worthless, guilty, and overwhelmed. Treatment typically involves talk therapy and medication.
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Schizoaffective Disorder
Schizoaffective disorder is a mental illness that features schizophrenia and a mood disorder, either major depression or bipolar disorder. Symptoms include agitation, suicidal thoughts, little need for sleep, delusions, hallucinations, and poor motivation. Treatment may involve psychotherapy, medication, skills training, or hospitalization.
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Schizophrenia
Schizophrenia is a disabling brain disorder that may cause hallucinations and delusions and affect a person's ability to communicate and pay attention. Symptoms of psychosis appear in men in their late teens and early 20s and in women in their mid-20s to early 30s. With treatment involving the use of antipsychotic medications and psychosocial treatment, schizophrenia patients can lead rewarding and meaningful lives.
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Seasonal Affective Disorder (SAD)
Seasonal affective disorder is a type of depression that tends to occur as the days grow shorter in the fall and winter. Symptoms of seasonal affective disorder include tiredness, fatigue, depression, irritability, body aches, poor sleep, and overeating.
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Stroke
A stroke is an interruption of the blood supply to part of the brain caused by either a blood clot (ischemic) or bleeding (hemorrhagic). Symptoms of a stroke may include weakness, numbness, double vision or vision loss, confusion, vertigo, difficulty speaking, or understanding speech. A physical exam, imaging tests, neurological exam, and blood tests may be used to diagnose a stroke. Treatment may include administration of clot-busting drugs, supportive care, and in some instances, neurosurgery. The risk of stroke can be reduced by controlling high blood pressure, high cholesterol, diabetes, and stopping smoking.
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What Is Schizotypal Personality Disorder?
Schizotypal personality disorder is characterized by odd behaviors, feelings, perceptions, and ways of relating to others that interfere with one's ability to function. Medication and psychotherapy can help the sufferer to manage their symptoms.
Examples of Medications for Apathy
- aripiprazole (Abilify)
- bupropion
- chlorpromazine - oral, Thorazine
- chlorpromazine-injection, Thorazine
- Citalopram
- clozapine (Clozaril, Fazacio ODT, Versacloz)
- desvenlafaxine (Pristiq, Khedezla)
- duloxetine
- escitalopram
- fluoxetine
- fluphenazine (Permitil, Prolixin)
- fluphenazine concentrate - oral, Prolixin
- fluphenazine liquid - oral, Prolixin
- fluvoxamine (Luvox)
- haloperidol
- olanzapine (Zyprexa, Zydis)
- paroxetine (Paxil, Pexeva)
- quetiapine (Seroquel)
- risperidone, Risperdal; Risperdal Consta, Risperdal M-TAB
- sertraline
- thiothixene - oral, Navane
- venlafaxine
- ziprasidone (Geodon)
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