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- Generalized Anxiety Disorder (GAD) Slideshow
- What are anti-anxiety (anxiolytic) drugs?
- How do anti-anxiety drugs and benzodiazepines work (mechanism of action)?
- What are the medical uses for anti-anxiety drugs?
- What are the side effects of anti-anxiety drugs?
- What other types of drugs are used to treat anxiety?
- What natural/herbal products and supplements treat anxiety?
- Which drugs or supplements interact with anti-anxiety drugs?
- List of examples of brand and generic names available for anti-anxiety drugs
- Are anti-anxiety drugs safe to use for treating my medical condition if I am pregnant or breastfeeding?
What are anti-anxiety (anxiolytic) drugs?
Anxiolytics (also termed anti-anxiety or anti-panic drugs) are medications that are used to treat a health condition called anxiety. The type of anxiety that requires treatment is called generalized anxiety disorder (GAD). This disorder causes excessive worry and anxiety, significant distress, and affects the ability for a person to function. Moreover, the symptoms of anxiety occur on most days for at least six months. Generalized anxiety disorder is treated with psychotherapy and medications.
How do anti-anxiety drugs and benzodiazepines work (mechanism of action)?
Antidepressants reduce anxiety by increasing the concentration of chemicals (neurotransmitters) that the brain uses to communicate. These neurotransmitters include serotonin, norepinephrine, and dopamine.
Buspirone may reduce anxiety by stimulating serotonin and dopamine receptors on nerves, thereby altering the chemical messages that nerves receive.
Benzodiazepines reduce symptoms of anxiety by increasing the action of a brain chemical called gamma-aminobutyric acid (GABA). GABA is a chemical that nerve cells use to communicate with each other and it reduces brain activity. It is believed that excessive activity in the brain may lead to anxiety or other psychiatric disorders.
Pregabalin is an anticonvulsant. Like benzodiazepines, Pregabalin also increases the action of GABA, and this may be its main mechanism for reducing anxiety.
What are the side effects of anti-anxiety drugs?
Some common side effects of anxiolytic drugs include:
What other types of drugs are used to treat anxiety?
What natural/herbal products and supplements treat anxiety?
Herbal medicines have been studied for the treatment of anxiety. Examples of herbal medications that have been used in clinical studies for treating anxiety include:
- St. Johns’s wort
- Ginkgo biloba
- Ashwagandha (Withania somnifera)
- Valerian (Valeriana officinalis)
- Theanine (found in green tea)
- Chamomile (Matricaria recutita)
- Lemon balm (Melissa officinalis)
Some clinical studies suggest that some herbal medicines may reduce anxiety symptoms. However, many of these clinical studies are small, and there also are clinical studies that show that some herbs are not useful therapy for anxiety. Patients should consult their doctor and pharmacist before self-treating anxiety symptoms with herbal medications. Herbal medications are not a replacement for standard therapy for anxiety.
Based on clinical studies, the effect of magnesium supplementation on anxiety symptoms may not be better than a sugar pill. Patients should consult their doctor and pharmacist before self-treating anxiety symptoms with nutritional supplements.
Researchers have looked into the effect of Yoga on improving anxiety. Some of these small clinical studies suggest that Yoga may improve anxiety symptoms by improving the levels of GABA in the brain. Since Yoga and other types of exercise are beneficial for overall health, it may be a useful addition to standard medical therapy for anxiety.
Which drugs or supplements interact with anti-anxiety drugs?
Selective serotonin reuptake inhibitors (SSRI) and serotonin-norepinephrine reuptake inhibitors
Selective serotonin reuptake inhibitors (SSRI) and serotonin-norepinephrine reuptake inhibitors (SNRI) have many important drug interactions when they are used for the treatment of anxiety or other health conditions.
Patients should not take anxiolytic drugs with any of the monoamine oxidase inhibitor (MAOI) class of antidepressants or other drugs that inhibit MAOIs such as linezolid [Zyvox] and intravenous methylene blue. Examples of MAOIs include:
- isocarboxazid (Marplan)
- phenelzine (Nardil)
- tranylcypromine (Parnate)
- selegiline (Eldepryl)
- procarbazine (Matulane)
Patients that take such combinations may develop confusion, high blood pressure, tremor, hyperactivity, coma, and death. Patients may develop similar reactions if they combine SSRIs or SNRIs with other drugs that increase serotonin in the brain.
Combining SSRIs or SNRIs with warfarin, aspirin, nonsteroidal anti-inflammatory drugs (for ex-ample ibuprofen (Motrin, Advil) or other drugs that affect bleeding may increase the likelihood of patients developing upper gastrointestinal bleeding when these drugs are used for the treatment of anxiety or other health conditions.
Other drug interactions with anxiolytics
- Combining benzodiazepines with alcohol or medications (for example, barbiturates, narcotics, other sedatives) that also suppress brain activity increases the chance of patients becoming sedated.
- Carbamazepine (Tegretol, Tegretol XR, Equetro, Carbatrol) and rifampin reduce the blood levels of some benzodiazepines and this may reduce the effect of affected benzodiazepines when they are used for the treatment of anxiety or other health conditions.
- Buspirone also interacts with MAOI class of antidepressants. Combining buspirone with warfarin (Coumadin), a blood thinner, may increase the effects of warfarin and increase the risk of bleeding in patients. Grapefruit juice increases the amount of buspirone in the blood of patients, possibly leading to side effects.
- Alcohol and drugs that cause sedation may increase the sedative effects of pregabalin.
- Combining pregabalin with pioglitazone (Actos) and rosiglitazone (Avandia) may increase the occurrence of weight gain, fluid retention, and possibly heart failure.
- Hydroxyzine increases the drying effects of other medications that have anticholinergic effects. Combining hydroxyzine with alcohol or medications that cause drowsiness increases the chance of sedation.
List of examples of brand and generic names available for anti-anxiety drugs
Selective serotonin reuptake inhibitors (SSRIs)
- Citalopram (Celexa)
- Escitalopram (Lexapro)
- Fluoxetine (Prozac)
- Fluvoxamine (Luvox)
- Paroxetine (Paxil)
- Sertraline (Zoloft)
- Vilazodone (Viibryd)
Serotonin-norepinephrine reuptake inhibitors (SNRIs)
Tricyclic antidepressants (TCAs)
- Amitriptyline (Elavil)
- Clomipramine (Anafranil)
- Doxepin (Sinequan)
- Imipramine (Tofranil)
- Desipramine (Norpramin)
- Nortriptyline (Pamelor - This drug is no longer available in the US.)
- Pregabalin (Lyrica)
- Hydroxyzine (Vistaril)
- Buspirone (Buspar)
Are anti-anxiety drugs safe to use for treating my medical condition if I am pregnant or breastfeeding?
- Some studies suggest that the use of SSRIs to treat medical conditions during pregnancy may be linked to increased risk of premature births, stillbirths, birth defects, and miscarriage.
- Benzodiazepines may harm the fetus if taken by pregnant women. Benzodiazepines also can enter breast milk and can cause weakness and weight loss in the newborn.
- Some studies suggest that hydroxyzine may cause birth defects when used during pregnancy. It is not known if hydroxyzine is excreted into breast milk.
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Anxiolytics (anti-anxiety, anti-panic) is a group of drug classes (for example, antidepressants, antihistamines, and benzodiazepines) that are prescribed for the treatment of anxiety disorders. Anxiolytics work (mechanism of action) depending upon to which drug class it belongs. Anxiety disorder drugs cause similar side effects, for example:
More serious side effects of anti-anxiety drugs include:
- Suicidal thoughts
- Dry mouth
- Elevated blood pressure
- Blurred vision
- Abnormal heartbeat
- Low blood pressure when standing (orthostatic hypotension)
Some natural herbal products and supplements like St. John's wort, ginkgo
biloba, valerian, lemon balm, and chamomile may be helpful in reducing anxiety.
Talk with your doctor about taking herbal or other supplement products.
Anxiolytics have several drug interactions. This type of drug is not recommended during pregnancy or while breastfeeding.
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Related Disease Conditions
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Anxiety is a feeling of apprehension and fear characterized by symptoms such as trouble concentrating, headaches, sleep problems, and irritability. Anxiety disorders are serious medical illnesses that affect approximately 19 million American adults. Treatment for anxiety may incorporate medications and psychotherapy.
Mental Illness in Children
About 5 million children and adolescents in the U.S. suffer from a serious mental illness such as eating disorders, anxiety disorders, disruptive behavior disorders, pervasive development disorders, elimination disorders, learning disorders, schizophrenia, tic disorders, and mood disorders. Symptoms of mental illness include frequent outbursts of anger, hyperactivity, fear of gaining weight, excessive worrying, frequent temper tantrums, and hearing voices that aren't there. Treatment may involve medication, psychotherapy, and creative therapies.
Panic attacks are sudden feelings of terror that strike without warning. These episodes can occur at any time, even during sleep. A person experiencing a panic attack may believe that he or she is having a heart attack or that death is imminent. The fear and terror that a person experiences during a panic attack are not in proportion to the true situation and may be unrelated to what is happening around them. Most people with panic attacks experience several of the following symptoms: racing heartbeat, faintness, dizziness, numbness or tingling in the hands and fingers, chills, chest pains, difficulty breathing, and a feeling of loss or control. There are several treatments for panic attacks.
Post-traumatic Stress Disorder
Post-traumatic stress disorder (PTSD), a psychiatric condition, can develop after any catastrophic life event. Symptoms include nightmares, flashbacks, sweating, rapid heart rate, detachment, amnesia, sleep problems, irritability, and exaggerated startle response. Treatment may involve psychotherapy, group support, and medication.
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Obsessive Compulsive Disorder (OCD)
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What Exactly Does a Psychotherapist Do?
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Depression in Children
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Is Valerian Root Good for Anxiety?
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Treatment & Diagnosis
Medications & Supplements
- Benzodiazepines (Benzodiazepine Drug Class)
- Zoloft (sertraline)
- Citalopram (Celexa)
- clonazepam (Klonopin)
- Lexapro (escitalopram)
- Lyrica (pregabalin)
- Cymbalta (duloxetine)
- diazepam (Valium, Diastat, Acudial, Diastat Pediatric, Diazepam Intensol)
- Drugs: Questions to Ask Your Doctor or Pharmacist about Your Drugs
- lorazepam (Ativan)
- Drug Interactions
- amitriptyline (Elavil, Endep)
- fluvoxamine (Luvox)
- fluoxetine (Prozac, Sarafem, Prozac Weekly)
- venlafaxine, Effexor XR (Effexor has been discontinued in the US)
- paroxetine (Paxil, Pexeva)
- ginkgo (Ginkgo biloba)
- tricyclic antidepressants-oral, injection
- Ativan (lorazepam) vs. Valium (diazepam)
- green tea (camellia sinensis) - oral
- desvenlafaxine (Pristiq, Khedezla)
- nortriptyline (Pamelor)
- Hydroxyzine vs. Valium
- Ativan vs. Xanax
- doxepin (Sinequan and Adapin are discontinued brand in the US; Silenor)
- Lemon Balm (Melissa officinalis)
- clomipramine (Anafranil)
- Klonopin (clonazepam) vs. Xanax (alprazolam)
- desipramine (Norpramin)
- oxazepam (Serax, Zaxopam)
- imipramine (Tofranil)
- kava (piper methysticum) - oral
- valerian (valeriana officinalis) - oral
- Aldactone (spironolactone) Side Effects, Interactions, and Warnings
- Antidepressants (Depression Medications)
- Tranxene (clorazepate dipotassium)
Prevention & Wellness
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FDA Prescribing Information.
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Shaheen L, Karen V. Nutritional and herbal supplements for anxiety and anxiety-related disor-ders: systematic review. Nutr J. 2010; 9:42
Li W, Goldsmith A. The effects of yoga on anxiety and stress. Altern Med Rev. 2012 Mar;17(1):21-35.