Antiphospholipid Syndrome: Symptoms & Signs

Medically Reviewed on 9/10/2019

Antiphospholipid syndrome is an autoimmune disorder in which people have many autoantibodies against phospholipids in the blood. This causes excessive blood clotting and can affect almost any organ in the body. Anticardiolipin and lupus anticoagulant antibodies are examples of antiphospholipid antibodies.

Signs and symptoms of antiphospholipid syndrome depend on the locations of blood clots and may include chest pain or blood clots in the lungs (pulmonary embolism), deep vein thrombosis, complications of pregnancy such as recurrent miscarriage, purplish skin discolorations, and limb swelling. Pain in the affected area is another possible associated symptom along with memory problems and neurologic problems.

Cause of antiphospholipid syndrome

Medical professionals do not understand the exact cause of antiphospholipid syndrome.

Other antiphospholipid syndrome symptoms and signs


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Kasper, D.L., et al., eds. Harrison's Principles of Internal Medicine, 19th Ed. United States: McGraw-Hill Education, 2015.