- Allergy Drug List
- Side Effects
- Drug Interactions
- Pregnancy & Breastfeeding
What are antihistamine (allergy) shots, and what are they used for?
Antihistamine shots are prescription medications that are used for the rapid medical treatment of conditions such as:
- Allergic reactions (a severe allergy to a substance)
- Motion sickness
- To induce sedation when injected into a patient
Antihistamine shots also are used to alleviate extra pyramidal symptoms of antipsychotic medications.
Histamine is a chemical that causes many signs and symptoms of allergy. Histamine is released from histamine-storing cells (mast cells) and attaches to other cells that have receptors for histamine on their surfaces. Histamine stimulates the cells to release chemicals that produce effects that we associate with allergy. Antihistamines blocks histamine receptors and thus prevent activation of cells with histamine receptors by histamine.
What are examples of generic and brand names of allergy shots?
Examples of the brand and generic names for this type of medication include:
- diphenhydramine (Benadryl)
- promethazine (Phenergan)
- hydroxyzine hydrochloride (Restall, Vistacot)
- dimenhydrinate (Dramamine, Driminate)
The formulation of this drug is available by prescription only to treat a patient with a specific condition. It is not available over-the-counter (OTC). Other formulations of antihistamine drugs are available over-the-counter that treat medical conditions such as:
Examples of OTC medicine available over-the-counter include:
What are the side effects of allergy shots?
The common side effects of this type of medication include:
Which drugs interact with antihistamine shots?
Antihistamine injections have additive effects if used with alcohol or other central nervous system depressant medications such as:
- alprazolam (Xanax)
- clonazepam (Klonopin)
- diazepam (Valium)
- zolpidem (Ambien)
- zaleplon (Sonata)
- butalbital/acetaminophen/caffeine (Fioricet)
- morphine (MSIR)
- hydromorphone (Dilaudid)
- buprenorphine (Buprenex)
- azelastine (Astelin)
Effects of antihistamines are prolonged if combined with monoamine oxidase inhibitors (MAOIs) such as:
- phenelzine (Nardil)
- selegiline (Zelapar, Emsam, and Eldepryl)
- tranylcypromine (Parnate)
- procarbazine (Matulane)
- rasagiline (Azilect)
- isocarboxazid (Marplan).
Antihistamine injections should be used with caution if the patient under medical care and receiving treatment with an MAOI drug.
What formulations of antihistamine injections are available?
- Prescription antihistamine injections are available in injection form.
- Diphenhydramine, promethazine, and dimenhydrinate are administered intramuscularly and intravenously.
- Hydroxyzine hydrochloride is administered only intramuscularly.
- Antihistamine injections are not recommended for administration via subcutaneous route.
Is it safe to have antihistamine shots during pregnancy or while breastfeeding?
- FDA lists diphenhydramine and dimenhydrinate as Pregnancy Category B and promethazine as Pregnancy Category C. Hydroxyzine does not have a Pregnancy Category. These categories mean that the safe and effective use of any antihistamine injection drug is not established in during pregnancy; therefore, if a patient is pregnant, medical treatment with this drug should be used only if clearly needed.
- It is not known whether an injected antihistamine drug enters breast milk; therefore, patients who are pregnant should seek medical advise and use caution before treatment with a prescription antihistamine injection medication in women who are breastfeeding.
Antihistamine shots or injections are prescription drugs used for the rapid treatment of allergic reactions, anxiety, nausea, vomiting, motion sickness, and induce sedation. The common side effects of this type of medication include dizziness, drowsiness (sleepiness), dry mouth, blurred vision, urinary retention, increased or decreased blood pressure, headache, abnormal heart rate, nausea, trouble breathing, tiredness (fatigue), and weakness.
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Related Disease Conditions
What Is Mucus?
Mucus is a normal substance produced by lining tissues in the body. Excess mucus or mucus that is yellow, green, brown, or bloody may indicate a problem. Mucus production may increase when allergies, a cold, flu, cough, or sore throat are present. Antihistamines and cold and flu medications may help alleviate excess mucus. A neti pot may be used to decrease nasal congestion and clear mucus.
The word "rash" means an outbreak of red bumps on the body. The way people use this term, "a rash" can refer to many different skin conditions. The most common of these are scaly patches of skin and red, itchy bumps or patches all over the place.
Sore throat (throat pain) usually is described as pain or discomfort in the throat area. A sore throat may be caused by bacterial infections, viral infections, toxins, irritants, trauma, or injury to the throat area. Common symptoms of a sore throat include a fever, cough, runny nose, hoarseness, earaches, sneezing, and body aches. Home remedies for a sore throat include warm soothing liquids and throat lozenges. OTC remedies for a sore throat include OTC pain relievers such as ibuprofen or acetaminophen. Antibiotics may be necessary for some cases of sore throat.
How Long Does an Allergic Reaction Last?
Allergic reactions may last for varying lengths of time. They may take a few hours to a few days to disappear. If the exposure to the allergen continues, such as during a spring pollen season, allergic reactions may last for longer periods such as a few weeks to months.
Hives, also called urticaria, is a raised, itchy area of skin. Most often the cause of hives is unknown. Sometimes it is a sign of an allergic reaction to food or medications, but the cause of the allergy (the allergen) is unknown. Dermatographism and swelling (angioedema) may accompany hives. Treatment to get rid of hives and alleviate symptoms typically includes antihistamines.
An allergy refers to a misguided reaction by our immune system in response to bodily contact with certain foreign substances. When these allergens come in contact with the body, it causes the immune system to develop an allergic reaction in people who are allergic to it. It is estimated that 50 million North Americans are affected by allergic conditions. The parts of the body that are prone to react to allergies include the eyes, nose, lungs, skin, and stomach. Common allergic disorders include hay fever, asthma, allergic eyes, allergic eczema, hives, and allergic shock.
Nosebleeds are common in dry climates during winter months, and in hot dry climates with low humidity. People taking blood clotting medications, aspirin, or anti-inflammatory medications may be more prone to nosebleeds. Other factors that contribute to nosebleed are trauma (including nose picking, especially in children), rhinitis (both allergic and nonallergic), and high blood pressure. First-aid treatments for a nosebleed generally do not need medical care. Frequent or chronic nosebleeds may require medical treatment such as over-the-counter (OTC) medication, and prevention of nose picking.
What Are the 4 Types of Allergic Reactions?
Allergists recognize four types of allergic reactions: Type I or anaphylactic reactions, type II or cytotoxic reactions, type III or immunocomplex reactions and type IV or cell-mediated reactions.
Panic attacks are sudden feelings of terror that strike without warning. These episodes can occur at any time, even during sleep. A person experiencing a panic attack may believe that he or she is having a heart attack or that death is imminent. The fear and terror that a person experiences during a panic attack are not in proportion to the true situation and may be unrelated to what is happening around them. Most people with panic attacks experience several of the following symptoms: racing heartbeat, faintness, dizziness, numbness or tingling in the hands and fingers, chills, chest pains, difficulty breathing, and a feeling of loss or control. There are several treatments for panic attacks.
Eustachian Tube Dysfunction
The Eustachian tube is a membrane-lined tube that connects the middle ear space to the back of the nose. Symptoms of Eustachian tube dysfunction or blockage include popping and/or clicking in the ear, and ear fullness and/or pain. Causes of Eustachian tube dysfunction or blockage include allergies, sinus infections, ear infections, and the common cold. Treatment includes home remedies to relieve pain and several maneuvers (swallowing, chewing gum, yawning, etc.), which can be done to improve Eustachian tube function. In severe cases, surgery may be necessary.
Can You Suddenly Become Allergic to Cats?
Yes, it is possible to suddenly become allergic to cats, since various allergies can develop at any point in your life, such as a pet allergy.
What Are the 20 Most Allergic Foods?
Common food allergies include milk, eggs, peanuts, tree nuts, sesame, soy, fish, shellfish, and wheat. Here are 20 of the top food allergies.
Fragrances and preservatives in cosmetics may cause allergic reactions in some people. Symptoms include redness, itching, and swelling after the product comes in contact with the person's skin. Treatment typically involves the use of over-the-counter cortisone creams.
The most common food allergies are to eggs, nuts, milk, peanuts, fish, shellfish, strawberries and tomatoes. Symptoms and signs of a food allergy reaction include nausea, vomiting, diarrhea, abdominal pain, itching, hives, eczema, asthma, lightheadedness, and anaphylaxis. Allergy skin tests, RAST, and ELISA tests may be used to diagnose a food allergy. Though dietary avoidance may be sufficient treatment for mild allergies, the use of an Epipen may be necessary for severe food allergies.
What Are the Symptoms of a Milk Allergy in Adults?
Milk allergy reactions may cause immediate or delayed symptoms. Learn to spot the signs and what foods to avoid if you have a dairy allergy.
Anaphylaxis is a serious allergic reaction that affects a number of different areas of the body at one time and can be fatal. Causes of anaphylaxis can be a food allergy, latex allergy, allergy to insect stings/bites, asthma, or other materials or conditions. Symptoms include flushing, itching, hives, anxiety, and rapid or irregular pulse. Severe symptoms may be throat and tongue swelling, swallowing, and difficulty breathing. Some disorders appear similar to anaphylaxis such as fainting, panic attacks, blood clots in the lungs, heart attacks, and septic shock. If you think that you may be having an anaphylactic reaction, seek emergency care or call 911 immediately.
Lice vs. Fleas
Lice and fleas are small wingless insects. Lice are parasites that can crawl and infest the human skin and scalp. Although they can bite people, fleas are parasites that mainly feed on non-human hosts and can jump from one host to another. Lice infestations and fleabites are treatable and typically do not cause long-term problems with proper treatments for home, people, and pets.
Motion sickness is a feeling of unwellness caused by the inner ear and balance systems. Motion sickness can include sea sickness, car sickness, and train or plane sickness. Symptoms include, headache, nausea, vomiting, fatigue, dizziness, cold sweats, and pale skin. Treatment for motion sickness includes home remedies such as ginger, avoiding large or fatty meals prior to traveling, and OTC and prescription medications.
Indoor allergens are substances that can cause an allergic reaction in some people. Common sources of indoor allergens include dust mites, cockroaches, molds, pets, and plants. Avoiding indoor allergens is one way to reduce allergy and asthma symptoms.
Hay Fever (Allergic Rhinitis)
Hay fever (allergic rhinitis) is an irritation of the nose caused by pollen and is associated with the following allergic symptoms: nasal congestion, runny nose, sneezing, eye and nose itching, and tearing eyes. Avoidance of known allergens is the recommended treatment, but if this is not possible, antihistamines, decongestants, and nasal sprays may help alleviate symptoms.
Eye allergy (or allergic eye disease) are typically associated with hay fever and atopic dermatitis. Medications and cosmetics may cause eye allergies. Allergic eye conditions include allergic conjunctivitis, conjunctivitis with atopic dermatitis, vernal keratoconjunctivitis, and giant papillary conjunctivitis. Dry eye, tear-duct obstruction, and conjunctivitis due to infection are frequently confused with eye allergies. Eye allergies may be treated with topical antihistamines, decongestants, topical mast-cell stabilizers, topical anti-inflammatory drugs, systemic medications, and allergy shots.
Cold, Flu, Allergy Treatments
Before treating a cold, the flu, or allergies with over-the-counter (OTC) medications, it's important to know what's causing the symptoms, which symptoms one wishes to relieve, and the active ingredients in the OTC product. Taking products that only contain the medications needed for relieving your symptoms prevents ingestion of unnecessary medications and reduces the chances of side effects.
What Causes Sudden Allergies in Adults?
Can you develop allergies as an adult? Learn about what causes sudden adult-onset allergies and how you can recognize the symptoms.
Is It Possible to Be Allergic to Cinnamon?
Cinnamon is a popular spice in many dishes. Cinnamon gives dishes a distinct flavor. Only a small percent of people experience allergic reactions after ingesting or coming into contact with cinnamon.
Allergy Treatment Begins at Home
Avoiding allergy triggers at home is one of the best ways to prevent allergy symptoms. Controlling temperature, humidity, and ventilation are a few ways to allergy-proof the home. Cleaning, vacuuming, and using HEPA air filters also helps control allergies.
Peanut allergies causes signs and symptoms that include hives, itching, redness, and a rash. Severe reactions may cause decreased blood pressure, lightheadedness, difficulty breathing, nausea, and behavioral changes. Someone with a peanut allergy should have an EpiPen with them at all times.
What Nuts Are the Worst for Allergies?
A nut allergy develops when the body's immune system becomes oversensitive to a particular protein in a nut. Nuts that are the worst for allergies include peanuts, walnuts, pecans, almonds, Brazil nuts and pine nuts.
What Is Allergic Cascade?
The allergic cascade refers to allergic reactions that happen in the body in response to allergens. A variety of immune cells and chemical messengers participate in the allergic cascade. Symptoms of the allergic cascade range from mild swelling and itching to full-blown anaphylactic shock. Allergen avoidance and medications are used to prevent or treat allergies.
How Long Does It Take for Allergic Conjunctivitis to Go Away?
Without treatment, allergic conjunctivitis symptoms could last the entire time that your critical allergen is present — which can vary greatly.
What Are the Best Treatments for Allergic Conjunctivitis?
Learn what medical treatments can ease allergic conjunctivitis symptoms and help speed up your eye allergy recovery.
Can You Eat Avocado if You Have a Nut Allergy?
Since avocado is classified as a fruit and not a tree nut, you should be able to eat avocados even if you have a nut allergy. However, some studies have shown that avocados have similar proteins as chestnuts. So if you’re allergic to chestnuts, you may have to avoid avocados.
Insect Sting Allergies
The majority of stinging insects in the United States are from bees, yellow jackets, hornets, wasps, and fire ants. Severity of reactions to stings varies greatly. Avoidance and prompt treatment are essential. In selected cases, allergy injection therapy is highly effective.
What Is the Most Common Tree Nut Allergy?
The most common nut allergies are cashew, walnut, hazelnut and pistachio. In the U.S. the most common nut allergy is cashew, followed by walnut. In the U.K. the most common nut allergy is hazelnut.
Do Allergy Desensitization Shots Work?
Allergies happen when your immune system overreacts to harmless substances called allergens. Allergy desensitization shots make your body less likely to react to allergen.
Sinus Infection vs. Allergies
Both sinus infections and allergies (allergic rhinitis) cause symptoms such as runny or stuffy nose and fatigue. Sinus infection (known as sinusitis) is inflammation of the sinuses, caused by infection from bacteria, viruses, and/or fungi (molds). Allergic rhinitis occurs when certain allergies cause nasal symptoms. When a person with allergies breathes in an allergen, such as pollen, dust, or animal dander, symptoms such as runny or stuffy nose, itching, sneezing, and fatigue occur.
Are Food Allergies Passed Down Genetically?
A food allergy is a condition that causes your immune system to fight against a particular part of food — which is called an allergen. Food allergies can be hereditary — that is, parents can pass the likelihood of developing a food allergy to their children through genes that code for inherited traits.
What Causes Allergy Flare-ups?
During certain seasons, allergies can make you miserable. Learn what causes allergy flare-ups during spring and summer.
How Do You Calm Down an Allergy Attack?
Here are thirteen tips to calm an allergy attack and put an end to constant sneezing, itching, and congestion.
What Are the 12 Food Allergens?
According to studies, the twelve most common food allergens include milk, peanuts, eggs, shellfish, soy, tree nuts, wheat, fish, corn, sesame seeds, mustard, and celery. Check out the center below for more medical references on food allergens, including multimedia (slideshows, images, and quizzes), related disease conditions, treatment and diagnosis, medications, and prevention or wellness.
Drug Allergy (Medication Allergy)
Drug or medication allergies are caused when the immune system mistakenly creates an immune response to a medication. Symptoms of a drug allergic reaction include hives, rash, itchy skin or eyes, dizziness, nausea, diarrhea, fainting, and anxiety. The most common drugs that people are allergic to include penicillins and penicillin type drugs, sulfa drugs, insulin, and iodine. Treatment may involve antihistamines or corticosteroids. An EpiPen may be used for life-threatening anaphylactic symptoms.
What Is the Difference Between Allergy and Hay Fever?
Hay fever is a type of allergy that occurs in response to specific allergens and typically lasts for months. Learn more about allergies vs. hay fever.
COVID-19 vs. Allergies
Though there is some overlap in allergy and COVID-19 signs and symptoms there are also significant differences. Symptoms that they have in common include headache, fatigue, tiredness, shortness of breath, wheezing, and sore throat. Fever does not occur with allergies but is one of the defining symptoms of COVID-19 infections.
How Do You Know If You Are Allergic to Mosquito Bites?
Mosquito bite allergies can cause issues if untreated. Learn the signs of a mosquito bite allergy, what causes it, and what you can do to treat it.
Latex allergy is a condition where the body reacts to latex, a natural product derived from the rubber tree. The reaction can either be delayed and cause a skin rash or immediate, which can lead to anaphylaxis. Avoiding latex is the most effective way to prevent an allergic reaction.
How Do I Know if I Am Lactose Intolerant or Allergic to Milk?
Lactose intolerance is caused by a deficiency of an enzyme (lactase) that helps digest the sugar (lactose) in milk. Milk allergy, on the other hand, is an adverse immune reaction to proteins found in milk. The symptoms of the two conditions are different.
Why Won’t My Allergy Symptoms Go Away?
Allergies happen when your body's immune system reacts to certain substances as though they are harmful. Allergy symptoms may not go away unless you avoid your triggers, stick to your medications, find the right combination of medications, and consider surgery.
What Are the Signs and Symptoms of Allergic Conjunctivitis?
What is allergic conjunctivitis, and how do you recognize it? Learn the signs of allergic conjunctivitis and how to treat it.
What Is the Fastest Way to Fix Seasonal Allergies?
Seasonal allergies are common and tend to ramp up during the spring and summer. Learn about how to get rid of seasonal allergies fast with these 13 home remedies.
What Are the 4 Most Common Allergens?
The four most common types of allergens include food and medications, pollen, pet dander, and latex.
How Common Is It to Be Allergic to Nickel?
Nickel allergies are common in 10 percent of the population in the United States and 18 percent of people in North America, including 11 million children.
What Causes Nose Allergies?
Nose allergies can be caused by irritants such as pollen, animal dander, and household dust. Learn about symptoms, treatment, and prevention.
How Do You Know if You Are Allergic to Pollen?
Pollen is a powdery yellow grain that fertilizes other plants of the same species. The only way to know for sure if a person has pollen allergy is to see a board-certified allergist for allergy testing.
What Are the Symptoms of Ragweed Allergy?
The common symptoms of ragweed allergy are sneezing, runny nose, itchy, watery red eyes, headache, nasal congestion, eye swelling, rashes and coughing.
What Are Typical Allergy Symptoms?
Allergy symptoms differ depending on the type of allergy and body part involved. For example, food allergies may cause different symptoms than nasal allergies or eye allergies. The severity of symptoms may also vary, ranging from mild irritation to a life-threatening reaction called anaphylaxis.
How Can I Help My Child With a Peanut Allergy?
Since there is no cure for peanut allergies, prevention and keeping an epinephrine injector (EpiPen) on hand is key to helping your child’s allergy.
What Foods Cause Oral Allergy Syndrome?
Oral allergy syndrome, also called pollen food allergy syndrome or PFAS, is a type of food allergy caused by certain allergens found in both pollen and raw vegetables and fruits and some nuts. Foods that cause oral allergy syndrome include those in the birch, grass and ragweed families.
What Does an Allergic Reaction Bump Look Like?
Hives due to allergic reactions appear as reddish or raised bumps or welts. Check out the center below for more medical references on allergic reactions, including multimedia (slideshows, images, and quizzes), related disease conditions, treatment and diagnosis, medications, and prevention or wellness.
Should I Exercise Outside if I Have Allergies?
An allergy is a condition in which the immune system overresponds to a foreign substance. With the right treatment and precautions, you can completely eliminate allergy flare-ups during your outdoor workout.
How Do You Tell If Your Child Has Allergies or a Cold?
Colds and allergies have different causes, but both involve the body's immune system. Since the symptoms of allergies and the symptoms of a cold overlap, it can be hard to tell which one your child has.
Why Are Allergies So Bad Right Now 2021?
Scientists believe that allergies are getting worse because of climate change.
Is Allergic Conjunctivitis the Same as Conjunctivitis?
Allergic conjunctivitis may occur along with sneezing, runny nose, or sinus headache. Many people also find that they are tired and feel agitated.
How Do You Get Tested for Food Allergies?
If you develop symptoms of a food allergy, your doctor will have you undergo a skin test or blood test to determine which foods you are allergic to.
What Are Typical Seasonal Allergy Symptoms?
Typical seasonal allergy symptoms include a stuffy or runny nose, sneezing, coughing, watery eyes, congestion, and a sore throat.
Is Food Intolerance the Same as Food Allergy?
Food intolerance is a condition in which an individual has difficulty in digesting certain foods. Consumption of these foods manifests as physical symptoms such as bloating, loose motion, gases, and bellyache. Food intolerance is quite common. Most people are aware of the foods that disagree with them.
Is My Sore Throat Allergies or COVID-19?
Sore throat can be a symptom of allergies or COVID-19, and it can be difficult to tell which one you have. Understanding the difference between these two illnesses can help.
Can Fall Allergies Cause Sinus Headaches?
Fall allergies can cause symptoms such as sneezing, congestion, and sinus headache. Learn more about causes, treatment, and prevention of fall allergies.
How Is COVID-19 Different From Allergies?
COVID-19 symptoms are often similar to symptoms of seasonal allergies, so it is important to know how to tell the difference. Learn how to distinguish between the two.
Treatment & Diagnosis
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Medications & Supplements
- Antihistamines (Oral)
- Nasal Decongestants
- dextromethorphan/decongestant/antihistamine - oral
- Side Effects of Phenergan with Codeine (promethazine and codeine)
- decongestant/antihistamine/anticholinergic - oral
- narcotic antitussive/antihistamine - oral
- decongestant/narcotic antitussive/acetaminoph/antihistamine - oral
- decongestant/narcotic antitussive/antihistamine - oral
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.