Anhydrous Crystalline Maltose

Reviewed on 6/11/2021
Other Name(s):

2-(Hydroxymethyl)-6-[4,5,6-Trihydroxy-2-(Hydroxymethyl)Oxan-3-yl]Oxyoxane-3,4,5-Triol; 4-O-Alpha-D-Glucopyranosyl-D-Glucose; Malt Sugar.


Anhydrous crystalline maltose is a molecule called a disaccharide that is formed by the joining of two sugar molecules.

Anhydrous crystalline maltose is taken by mouth to relieve symptoms of Sjogren's syndrome.

In manufacturing, anhydrous crystalline maltose is used as a food stabilizer. It is also added to certain cosmetics and pharmaceuticals to absorb water.

How does it work?

There isn't enough information to know how anhydrous crystalline maltose might work.


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Uses & Effectiveness

Insufficient Evidence to Rate Effectiveness for...

  • An autoimmune disorder called Sjogren's syndrome.
  • Early research suggests that taking anhydrous crystalline maltose by mouth three times daily for up to 24 weeks reduces symptoms of dry eyes and dry mouth in people with Sjogren's syndrome.
  • Other conditions.
More evidence is needed to rate the effectiveness of anhydrous crystalline maltose for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

Side Effects

Anhydrous crystalline maltose is POSSIBLY SAFE when taken by mouth as a medicine for up to 6 months. It is not clear if anhydrous crystalline maltose causes side effects. So far, none have been reported.


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Special Precautions & Warnings

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking anhydrous crystalline maltose if you are pregnant or breast-feeding. Stay on the safe side and avoid use.


The appropriate dose of anhydrous crystalline maltose depends on several factors such as the user's age, health, and several other conditions. At this time, there is not enough scientific information to determine an appropriate range of doses for anhydrous crystalline maltose. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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Fox, P. C., Cummins, M. J., and Cummins, J. M. A third study on the use of orally administered anhydrous crystalline maltose for relief of dry mouth in primary Sjogren's syndrome. J Altern Complement Med 2002;8(5):651-659. View abstract.

Fox, P. C., Cummins, M. J., and Cummins, J. M. Use of orally administered anhydrous crystalline maltose for relief of dry mouth. J Altern Complement Med 2001;7(1):33-43. View abstract.

Oomori T, Khajavi SH, Kimura Y, Adachi S, Matsuno R. Hydrolysis of disaccharides containing glucose residue in subcritical water. Biochem Eng J. 2004;18(2):143-147.

Sankar V, Hearnden V, Hull K, et al. Local drug delivery for oral mucosal diseases: challenges and opportunities. Oral Dis. 2011;17 Suppl 1:73-84. View abstract.