Amyloidosis: Symptoms & Signs

Medically Reviewed on 11/12/2020

Amyloidosis is a rare disease. Amyloidosis can occur as an isolated disease (immunoglobulin light chain or AL amyloidosis, formerly called primary amyloidosis) or as a result of another illness (secondary amyloidosis).

Signs and symptoms of amyloidosis vary widely and depend on the location in the body of the abnormal protein deposits, which can affect many different organs. Symptoms can include

Other associated symptoms and signs can include a

Cause of amyloidosis

Amyloidosis is a consequence of abnormal protein (known as amyloid) deposits in different body tissues and organs. A rare form of the condition is caused by an inherited gene mutation.

Other amyloidosis symptoms and signs

  • Abnormally Large Tongue
  • Bruising
  • Carpal Tunnel Syndrome
  • Diarrhea
  • Enlarged Heart or Irregular Heart Rate
  • Fatigue
  • Generalized Body Swelling
  • Nervous System Dysfunction
  • Pain in the Abdomen, Foot, or Hands
  • Pins and Needles Feeling or Reduced Sensation of Touch
  • Rash of Small Purplish Spots or Red Spots
  • Shortness of Breath or Shortness of Breath When Lying Down


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Jameson, J. Larry, et al. Harrison's Principles of Internal Medicine, 20th Ed. New York: McGraw-Hill Education, 2018.