- HIV AIDS Myths and Facts Slideshow Pictures
- Take the HIV/AIDS Quiz
- AIDS Retrospective Slideshow Pictures
- What is amprenavir, and how does it work (mechanism of action)?
- What brand names are available for amprenavir?
- Is amprenavir available as a generic drug?
- Do I need a prescription for amprenavir?
- What are the side effects of amprenavir?
- What is the dosage for amprenavir?
- Is amprenavir safe to take if I'm pregnant or breastfeeding?
- What else should I know about amprenavir?
What is amprenavir, and how does it work (mechanism of action)?
This drug was discontinued as of October of 2007.
Amprenavir is an oral medication that is used for treating infections with the human immunodeficiency virus (HIV). It is in a class of drugs called protease inhibitors which, among others, includes indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir) and saquinavir (Invirase, Fortovase). During infection with HIV, the HIV virus multiplies within the body's cells. Viruses are released from the cells and spread throughout the body where they infect other cells. In this manner, HIV infection is perpetuated among new cells that the body produces continually. During the production of the viruses, new proteins are made. Some of the proteins are structural proteins, that, is, proteins that form the body of the virus. Other proteins are enzymes which manufacture DNA and other components for the new viruses. Protease is the enzyme that forms the new structural proteins and enzymes. Amprenavir blocks the activity of protease and results in the formation of defective viruses that are unable to infect the body's cells. As a result, the number of viruses in the body (the viral load) decreases. Nevertheless, amprenavir does not prevent the transmission of HIV among individuals, and it does not cure HIV infections or AIDS. Amprenavir was approved by the FDA in April 1999.
What are the side effects of amprenavir?
The most frequent side effects are headache, weakness, diarrhea, nausea and stomach pain. Amprenavir may also cause severe skin reactions and breakdown of red blood cells. The propylene glycol in the oral solution can cause seizures, stupor, increased heart rate, metabolic disturbance, and kidney failure. Like other protease inhibitors, use of amprenavir may be associated with redistribution or accumulation of body fat, increased cholesterol and worsening of diabetes.
Quick GuideHIV AIDS Facts: Symptoms and Treatments
What is the dosage for amprenavir?
The recommended dose is based on age, weight and the formulation. Individuals 4-12 years old or 13-16 years old and weighing less than 50 kg should receive 22.5 mg/kg twice daily or 17 mg/kg three times daily of the oral solution or 20 mg/kg twice daily or 15 mg/kg three times daily of the capsules.
Individuals 13- 16 years old who weigh 50 kg or more and individuals older than 16 years of age should receive 1400 mg twice daily of the oral solution or 1200 mg twice daily of the capsules.
The maximum daily dose is 2800 mg. Amprenavir capsules and solution are not interchangeable milligram for milligram. The oral solution should only be used when it is not possible to administer the capsules.
Amprenavir can be taken with or without food. However, foods high in fat may decrease the absorption of amprenavir and should be avoided.
Is amprenavir safe to take if I'm pregnant or breastfeeding?
It is not known whether amprenavir is secreted in breast milk. Nevertheless, HIV-infected mothers should not breast-feed because of the potential risk of transmitting HIV to an infant that is not infected.
What else should I know about amprenavir?
What preparations of amprenavir are available?
Capsule: 50 and 150 mg; Solution: 15 mg/ml
How should I keep amprenavir stored?
Capsules and oral solution should be stored at room temperature, 20 C to 25 C (68 F to 77 F).
Medically reviewed by John Cunha, DO
Reference: FDA Prescribing Information
Amprenavir (Agenerase - discontinued brand) is a drug prescribed to treat infections with the human immunodeficiency virus (HIV). Side effects, drug interactions, and pregnancy safety information should be reviewed prior to taking this medication.
Multimedia: Slideshows, Images & Quizzes
Related Disease Conditions
Human Immunodeficiency Virus (HIV)
The human immunodeficiency virus (HIV) causes HIV infection and the acquired immunodeficiency syndrome (AIDS). Symptoms and signs...
Acquired Immunodeficiency Syndrome
AIDS is the advanced stage of HIV infection. Symptoms and signs of AIDS include pneumonia due to Pneumocystis jiroveci,...
Treatment & Diagnosis
- HIV-AIDS FAQs
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Generic Drugs, Are They as Good as Brand-Names?
- Drugs: Buying Prescription Drugs Online Safely
- Medication Disposal - What to Do with Old or Unusable Medication
- Dangers of Mixing Medications
- Drugs: The Most Common Medication Errors
Medications & Supplements
Prevention & Wellness
Daily Health News
Resources for Staying Well
Subscribe to MedicineNet's General Health Newsletter
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Reference: FDA Prescribing Information
Top amprenavir Related ArticlesComplete List
Acquired Immunodeficiency Syndrome (AIDS)AIDS is the advanced stage of HIV infection. Symptoms and signs of AIDS include pneumonia due to Pneumocystis jiroveci, tuberculosis, toxoplasmosis, seizures, weakness, meningitis, yeast infection of the esophagus, and Kaposi's sarcoma. Anti-retroviral therapy (HAART) is used in the treatment of AIDS.
atazanavirAtazanavir (Reyataz) is a drug prescribed for the treatment of HIV infections. Side effects, drug interactions, and patient warnings should be reviewed prior to taking this medication.
Drug InteractionsDrug interactions occur frequently. Get facts about the types of drug interactions, what substances or other things that may interact with drugs such as OTC drug and prescription drugs, vitamins, food(s) (grapefruit), and laboratory tests. Find out how to protect yourself from potential drug interactions.
Drugs: What You Should Know About Your DrugsImportant information about your drugs should be reviewed prior to taking any prescription drug. Side effects, drug interactions, warnings and precauctions, dosage, what the drug is used for, what to do if you miss a dose, how the drug is to be stored, and generic vs. brand names.
HIV/AIDS QuizNow, more than ever, you should know about HIV/AIDS, especially its causes, symptoms treatments, and complications. Take the HIV/AIDS Quiz now!
Human Immunodeficiency Virus (HIV)The human immunodeficiency virus (HIV) causes HIV infection and the acquired immunodeficiency syndrome (AIDS). Symptoms and signs of HIV infection include fatigue, enlarged lymph glands, and recurrent vaginal yeast infections. Highly active antiretroviral therapy (ART) is the standard treatment for HIV infection.
indinavirIndinavir (Crixivan) is a medication prescribed for the treatment of infections with the human immunodeficiency virus (HIV). Side effects, dosing, and in particular, drug interactions should be discussed with our health care professional prior to taking this medication.
nelfinavirNelfinavir (Viracept) is a drug prescribed to be used in combination with other anti-HIV drugs to treat HIV infection. Side effects, drug interactions, dosage, and pregnancy safety should be reviewed prior to taking this medication.
ritonavirRitonavir (Norvir) is a drug used in combination with other drugs for the treatment of HIV infection. Side effects, drug interactions, and dosing information should be reviewed prior to taking this medication.