- Side Effects
- Drug Interaction
- Preparation & Storage
What is Adderall, and how does it work (mechanism of action)?
- Amphetamines stimulate the brain by increasing the level of neurotransmitters, dopamine, and norepinephrine, in the brain.
- (Neurotransmitters are chemicals produced by nerves that are released and attach to other nearby nerves as a means of communication among nerves.)
The exact mechanism of action in ADHD is unknown.
Adderall XR is an extended-release form of Adderall.
Adderall was approved by the FDA in 1996.
What brand names are available for amphetamine and dextroamphetamine?
Adderall, Adderall XR
Are amphetamine and dextroamphetamine available as generic drugs?
Yes (Adderall), No (Adderall XR)
Do I need a prescription for amphetamine and dextroamphetamine?
What are the side effects of Adderall?
Side effects of amphetamines include excessive stimulation of the nervous system leading to:
- hallucinations, and
- convulsions (seizures).
Other important side effects include:
- Sudden death,
- heart attack,
- manic episodes,
- aggressive behavior or hostility,
- growth suppression (long-term use),
- dependence, and
- withdrawal symptoms
- The erection usually resolves when the drug is stopped.
- Prompt medical attention is required in the event of suspected priapism.
What is the dosage for Adderall?
Adderall usually is taken once or twice a day.
- Doses should be separated by at least 4-6 hours.
- The recommended dose is 2.5 to 60 mg daily depending on the patient's age and the condition being treated.
Adderall XR is taken once daily.
- The recommended dose is 5-40 mg daily administered in the morning.
- The entire contents of the Adderall XR capsules may be sprinkled into applesauce and consumed immediately.
Administer amphetamines during waking hours and avoid late evening doses to avoid insomnia.
Which drugs or supplements interact with Adderall?
- Amphetamines should not be taken with monoamine oxidase inhibitor (MAOI) drugs including:
- phenelzine (Nardil),
- tranylcypromine (Parnate), and
- Avoid using amphetamines within 14 days of using MAOI drugs.
- Patients receiving antihypertensive medications may experience loss of blood pressure control with amphetamines.
- Antacids may increase the absorption of amphetamine salts and increase their effectiveness and side effects.
Is Adderall safe to take if I'm pregnant or breastfeeding?
- Do not use amphetamines during pregnancy. Infants who are born to mothers dependent on amphetamines exhibit symptoms of withdrawal and have an increased risk of low birth weight.
- Mothers taking amphetamines should refrain from nursing their infants because these drugs are excreted in human milk and can have undesirable effects on the child.
What else should I know about Adderall?
What preparations of amphetamine and dextroamphetamine are available?
- Adderall tablets: 5, 7.5, 10, 12.5, 15, 20, and 30 mg.
- Adderall XR capsules: 5, 10, 15, 20, 25, and 30 mg.
How should I keep amphetamine and dextroamphetamine stored?
- Tablets should be stored at room temperature, between 15 C and 30 C (59 F and 86 F).
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.