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- What is amoxicillin? How does it work (mechanism of action)?
- Why are the uses for amoxicillin (what does it treat)?
- What are amoxicillin side effects?
- What is the dosage for amoxicillin?
- Which drugs or supplements interact with amoxicillin?
- Is amoxicillin safe to take if I am pregnant or breastfeeding?
- What else should I know about amoxicillin?
What is amoxicillin? How does it work (mechanism of action)?
- ampicillin (Unasyn),
- piperacillin (Pipracil),
- ticarcillin (Ticar), and
- several others.
These antibiotics all have a similar mechanism of action. They do not directly kill bacteria, but they stop bacteria from multiplying by preventing bacteria from forming the walls that surround them. The walls are necessary to protect bacteria from their environment and to keep the contents of the bacterial cell together. Bacteria cannot survive without a cell wall. Amoxicillin is effective against many different bacteria including H. influenzae, N. gonorrhoea, E. coli, Pneumococci, Streptococci, and certain strains of Staphylococci.
The FDA approved Amoxicillin in December 1974.
Why are the uses for amoxicillin (what does it treat)?
- Amoxicillin is used to treat infections due to bacteria that are susceptible to the effects of amoxicillin.
- Common bacterial infections that amoxicillin is used for include infections of the
- It also is used to treat gonorrhea.
What are amoxicillin side effects?
Side effects due to amoxicillin include:
- abdominal pain,
- easy bruising,
- rash, and
- allergic reactions.
People who are allergic to the cephalosporin class of antibiotics, which are related to the penicillins, for example, cefaclor (Ceclor), cephalexin (Keflex), and cefprozil (Cefzil), may or may not be allergic to penicillins.
Serious but rare reactions include:
- severe allergic reactions (anaphylaxis), and
- low platelet (thrombocytopenia) or red blood cell count.
Amoxicillin can alter the normal bacteria in the colon and encourage overgrowth of some bacteria such as Clostridium difficile which causes inflammation of the colon (pseudomembranous colitis). Patients who develop signs of pseudomembranous colitis after starting amoxicillin (diarrhea, fever, abdominal pain, and possibly shock) should contact their physician immediately.
What is the dosage for amoxicillin?
- For most infections in adults the dose of amoxicillin is 250 mg every 8 hours, 500 mg every 8 hours, 500 mg every 12 hours or 875 mg every 12 hours, depending on the type and severity of infection.
- For the treatment of adults with gonorrhea, the dose is 3 g given as one dose.
- For most infections, children older than 3 months but less than 40 kg are treated with 25 or 45 mg/kg/day in divided doses every 12 hours or 20 or 40 mg/kg/day with one-third of the daily dose given every 8 hours depending on the type and severity of the infection.
- Amoxicillin can be taken with or without food.
Which drugs or supplements interact with amoxicillin?
Amoxicillin is rarely associated with important drug interactions.
Daily Health News
Is amoxicillin safe to take if I am pregnant or breastfeeding?
- Penicillins are generally considered safe for use by pregnant women who are not allergic to penicillin.
- Small amounts of amoxicillin may be excreted in breast milk and may cause diarrhea or allergic responses in nursing infants. Amoxicillin is generally considered safe to use while breastfeeding. Amoxicillin is used to treat infections in the newborn.
What else should I know about amoxicillin?
- Capsules: 250 and 500 mg.
- Tablets: 500 and 875 mg.
- Chewable tablets: 125, 200, 250, and 400 mg.
- Powder for suspension: 50 mg/ml ; 125, 200, 250, and 400 mg/5 ml.
- Tablet (Extended release): 775 mg
- Amoxicillin capsules as well as the 125 and 250 mg dry powders should b e stored at or below 20 C (68 F).
- Chewable tablets as well as 200 and 400 mg dry powders should be stored at or below 25 C(77 F).
- Trimox capsules and unreconstituted powder should be stored at or below 20 C (68 F), and chewable tablets should be stored at room temperature 15 C to 30 C (59 F to 86 F).
- Powder that has been mixed with water should be discarded after 14 days. Refrigeration is preferred but not required for powder mixed with water.
Other information about amoxicillin
- Amoxicillin is available in generic form and is available by prescription only.
- Brand names available in the US for amoxicillin are Amoxil, Moxatag, and Larotid.
Amoxicillin (Amoxil, Moxatag, Larotid) is an antibiotic that belongs to a class of antibiotics called penicillins. Common infections that amoxicillin is used to treat include middle ear infections, tonsillitis, laryngitis, bronchitis, pneumonia, skin, gonorrhea, and urinary tract infections.
Common side effects of amoxicillin include nausea, itching, vomiting, confusion, abdominal pain, and easy bruising.
Drug interactions, dosing, storage, and pregnancy and breastfeeding safety should be reviewed prior to taking penicillins.
Dispermox, Trimox, Wymox, Utimox, and Polymox are discontinued brands and are no longer available in the US.
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Treatment & Diagnosis
- Urine Odor
- Cloudy Urine
- Bladder Infection
- Urinary Tract Infection (UTI)
- Sinus Infection (Sinusitis)
- Sore Throat (Pharyngitis)
- Middle Ear Infection (Otitis Media)
- Helicobacter pylori (H. pylori) Infection
- Lyme Disease
- Doctor: Checklist to Take To Your Doctor's Appointment
- Gum Disease
- Acute Sinusitis
- Scarlet Fever
- Urinary Tract Infection FAQs
- STD FAQs
- Skin FAQs
- Pneumonia FAQs
- Acne FAQs
- Rosacea FAQs
- Strep Streptococcal Throat Infection FAQs
- Ear Infection FAQs
- Medication Disposal
- Dangers of Mixing Medications
- Tonsils and Adenoids, Parent's Perspective
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Drugs: Buying Prescription Drugs Online Safely
- Drugs: The Most Common Medication Errors
- Antibiotics 101
- Generic Drugs, Are They as Good as Brand-Names?
- Antibiotics 101 - Audio Podcast
Medications & Supplements
- Amoxicillin vs. Levaquin (Strength and Effectiveness)
- Amoxicillin vs. Augmentin (Comparison of Side Effects and Antibiotic Uses)
- Penicillin (Antibiotics)
- Drugs: Questions to Ask Your Doctor or Pharmacist about Your Drugs
- Drug Interactions
- penicillin V, (Veetids and Pen-Vee-K have been discontinued)
- probenecid, (Benemid - brand no longer available)
Prevention & Wellness
- Antibiotic Resistance Common in Kids' Urinary Tract Infections
- Strep Throat: How Soon Can Kids Go Back to School?
- Prescription Meds: Too Common in Pregnancy?
- Simpler Antibiotic Regimen Helps Sick Babies in Developing Nations
- Certain Heart Drug, Antibiotic Combo Might Be Fatal for Seniors
- Study Finds Many Flu Patients Not Treated Appropriately
- New Push by Doctors to Limit Antibiotic Use in Kids
- Many Docs Wrongly Prescribe Powerful Antibiotics: Study
- Pediatrics Group Issues New Ear Infection Guidelines
- Deer Ticks Carry Yet Another Bacterial Threat
- Most Coughs Don't Respond to Antibiotics, Study Confirms
- Kids' Strep Throat: Likely No Need to Lose Tonsils
- New Strep Throat Guidelines Tackle Antibiotic Resistance
- Prescription Drugs for Kids: What's Up, Down
- Z-Pak Heart Attack?
- Germs Behind Urinary Tract Infections Becoming More Resistant to Drugs
- Antibiotics Do Not Reduce Symptoms of Sinus Infection
- The 10 Most Prescribed Drugs
- Ear Infections: Antibiotics Often Not Needed
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