- What are the uses for amlodipine and benazepril?
- What are the side effects of amlodipine and benazepril?
- What is the dosage for amlodipine and benazepril?
- Which drugs or supplements interact with amlodipine and benazepril?
- Is amlodipine and benazepril safe to take if I'm pregnant or breastfeeding?
- What else should I know about amlodipine and benazepril?
What are the uses for amlodipine and benazepril?
Lotrel is used for treating high blood pressure (hypertension) when blood pressure is not adequately controlled with either of its constituent drugs alone.
What brand names are available for amlodipine and benazepril?
Is amlodipine and benazepril available as a generic drug?
Do I need a prescription for amlodipine and benazepril?
What are the side effects of amlodipine and benazepril?
Lotrel causes the same side effects as benazepril and amlodipine.
Common side of Lotrel include
- water retention (edema) in legs and arms,
- edema in the lungs
- stomach pain,
- muscle cramps,
- sexual problems, and
Other side effects of Lotrel include
- kidney failure,
- blood disorders,
- overgrowth of gums,
- heart palpitations,
- reduced number of platelets in the blood, and
- serious skin reactions also may occur.
What is the dosage for amlodipine and benazepril?
The dose of Lotrel is tailored to the patient's needs. The dose is one capsule once daily.
Which drugs or supplements interact with amlodipine and benazepril?
- Combining benazepril with potassium supplements, potassium containing salt substitutes, and potassium conserving diuretics such as amiloride (Moduretic), spironolactone (Aldactone), and triamterene (Dyazide, Maxzide), can lead to dangerously high blood levels of potassium.
- There have been reports of increased lithium (Eskalith, Lithobid) levels when lithium is used in combination with ACE inhibitors. The reason for this interaction is not known, but the increased levels may lead to toxicity from lithium.
- There have been reports that aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Children's Advil/Motrin, Medipren, Motrin, Nuprin, PediaCare Fever, etc.), indomethacin (Indocin, Indocin-SR), and naproxen (Anaprox, Naprelan, Naprosyn, Aleve) may reduce the effects of ACE inhibitors. Combining ACE inhibitors with NSAIDs in patients who are elderly, volume-depleted (including those on diuretic therapy), or with poor kidney function may result in reduced kidney function, including kidney failure. These effects usually are reversible.
- Nitritoid reactions (symptoms include facial flushing, nausea, vomiting and low blood pressure or hypotension) may occur when injectable gold (sodium aurothiomalate), used in the treatment of rheumatoid arthritis, is combined with ACE inhibitors.
- Amlodipine increases blood levels of simvastatin (Zocor). The dose of simvastatin should be limited to 20 mg daily when combined with amlodipine.
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Is amlodipine and benazepril safe to take if I'm pregnant or breastfeeding?
- ACE inhibitors, including benazepril, can be harmful to the fetus and should not be taken by pregnant women.
- Small amounts of benazepril are excreted in breast milk. It is not known whether amlodipine is excreted in breast milk. Lotrel or nursing should be discontinued.
What else should I know about amlodipine and benazepril?
What preparations of amlodipine and benazepril are available?
Capsules (mg amlodipine/mg benazepril): 2.5/10; 5/10;5/20; 5/40; 10/20; and 10/40
How should I keep amlodipine and benazepril stored?
Lotrel should be stored at room temperature, 15 C - 30 C (59 C - 86 F).
Lotrel (amlodipine and benazepril) is a combination drug prescribed for the treatment of high blood pressure. Side effects include sexual problems, drowsiness, headache, fatigue, nausea, and stomach pain. Water retention in the legs and arms Drug interactions, warnings and precautions, and pregnancy and breastfeeding safety information should be reviewed prior to taking any medication.
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High Blood Pressure (Hypertension)
High blood pressure (hypertension) is a disease in which pressure within the arteries of the body is elevated. About 75 million people in the US have hypertension (1 in 3 adults), and only half of them are able to manage it. Many people do not know that they have high blood pressure because it often has no has no warning signs or symptoms. Systolic and diastolic are the two readings in which blood pressure is measured. The American College of Cardiology released new guidelines for high blood pressure in 2017. The guidelines now state that blood normal blood pressure is 120/80 mmHg. If either one of those numbers is higher, you have high blood pressure. The American Academy of Cardiology defines high blood pressure slightly differently. The AAC considers 130/80 mm Hg. or greater (either number) stage 1 hypertension. Stage 2 hypertension is considered 140/90 mm Hg. or greater. If you have high blood pressure you are at risk of developing life threatening diseases like stroke and heart attack.REFERENCE: CDC. High Blood Pressure. Updated: Nov 13, 2017.
Things to Know About High Blood Pressure Treatment
High blood pressure (hypertension) means high pressure (tension) in the arteries. Treatment for high blood pressure include lifestyle modifications (alcohol, smoking, coffee, salt, diet, exercise), drugs and medications such as ACE inhibitors, angiotensin receptor blockers, beta blockers, diuretics, calcium channel blockers (CCBs), alpha blockers, clonidine, minoxidil, and Exforge.
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