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- What brand names are available for amlodipine and benazepril?
- Is amlodipine and benazepril available as a generic drug?
- Do I need a prescription for amlodipine and benazepril?
- What are the uses for amlodipine and benazepril?
- What are the side effects of amlodipine and benazepril?
- What is the dosage for amlodipine and benazepril?
- Which drugs or supplements interact with amlodipine and benazepril?
- Is amlodipine and benazepril safe to take if I'm pregnant or breastfeeding?
- What else should I know about amlodipine and benazepril?
What are the uses for amlodipine and benazepril?
What are the side effects of amlodipine and benazepril?
Lotrel causes the same side effects as benazepril and amlodipine.
Common side of Lotrel include
- water retention (edema) in legs and arms,
- edema in the lungs
- stomach pain,
- muscle cramps,
- sexual problems, and
Other side effects of Lotrel include
Quick GuideHow to Lower Blood Pressure: Exercise Tips
What is the dosage for amlodipine and benazepril?
The dose of Lotrel is tailored to the patient's needs. The dose is one capsule once daily.
Which drugs or supplements interact with amlodipine and benazepril?
- Combining benazepril with potassium supplements, potassium containing salt substitutes, and potassium conserving diuretics such as amiloride (Moduretic), spironolactone (Aldactone), and triamterene (Dyazide, Maxzide), can lead to dangerously high blood levels of potassium.
- There have been reports of increased lithium (Eskalith, Lithobid) levels when lithium is used in combination with ACE inhibitors. The reason for this interaction is not known, but the increased levels may lead to toxicity from lithium.
- There have been reports that aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Children's Advil/Motrin, Medipren, Motrin, Nuprin, PediaCare Fever, etc.), indomethacin (Indocin, Indocin-SR), and naproxen (Anaprox, Naprelan, Naprosyn, Aleve) may reduce the effects of ACE inhibitors. Combining ACE inhibitors with NSAIDs in patients who are elderly, volume-depleted (including those on diuretic therapy), or with poor kidney function may result in reduced kidney function, including kidney failure. These effects usually are reversible.
- Nitritoid reactions (symptoms include facial flushing, nausea, vomiting and low blood pressure or hypotension) may occur when injectable gold (sodium aurothiomalate), used in the treatment of rheumatoid arthritis, is combined with ACE inhibitors.
- Amlodipine increases blood levels of simvastatin (Zocor). The dose of simvastatin should be limited to 20 mg daily when combined with amlodipine.
Is amlodipine and benazepril safe to take if I'm pregnant or breastfeeding?
- ACE inhibitors, including benazepril, can be harmful to the fetus and should not be taken by pregnant women.
- Small amounts of benazepril are excreted in breast milk. It is not known whether amlodipine is excreted in breast milk. Lotrel or nursing should be discontinued.
What else should I know about amlodipine and benazepril?
What preparations of amlodipine and benazepril are available?
Capsules (mg amlodipine/mg benazepril): 2.5/10; 5/10;5/20; 5/40; 10/20; and 10/40
How should I keep amlodipine and benazepril stored?
Lotrel should be stored at room temperature, 15 C - 30 C (59 C - 86 F).
Reference: FDA Prescribing Information
Quick GuideHow to Lower Blood Pressure: Exercise Tips
Lotrel (amlodipine and benazepril) is a combination drug prescribed for the treatment of high blood pressure. Side effects include:
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Amlodipine besylate (Norvasc) is a drug that belongs to the drug class of calcium channel blockers (CCBs), and is prescribed for the treatment and prevention of angina (heart or chest pain) that results from coronary spasm and from exertion. Norvasc also is prescribed for the treatment of high blood pressure. Side effects include:
Drug interactions, dosing, and pregnancy and breastfeeding safety information should be reviewed prior to taking any medication.
Blood Pressure PictureThe blood pressure is the pressure of the blood within the arteries. See a picture of Blood Pressure and learn more about the health topic.
Calcium Channel Blockers
Calcium channel blockers (CCBs) are a class of drugs that dilate the arteries, and are used for treating:
- High blood pressure
- Abnormally rapid heart rhythms
- Pulmonary hypertension
- Raynaud's syndrome
- Subarachnoid hemorrhage
Calcium channel blockers also are prescribed for the prevention of migraine headaches and angina.
CCBs may also be prescribed after a heart attack.
Examples of calcium channel blockers (CCBs) approved in the U. S. include:
- nisoldipine (Sular)
- nifedipine (Adalat, Procardia)
- nicardipine (Cardene)
- isradipine (Dynacirc)
- nimodipine (Nimotop)
- felodipine (Plendil)
- amlodipine (Norvasc)
- diltiazem (Cardizem)
- verapamil (Calan, Isoptin)
Drug InteractionsDrug interactions occur frequently. Get facts about the types of drug interactions, what substances or other things that may interact with drugs such as OTC drug and prescription drugs, vitamins, food(s) (grapefruit), and laboratory tests. Find out how to protect yourself from potential drug interactions.
Drugs: What You Should Know About Your DrugsImportant information about your drugs should be reviewed prior to taking any prescription drug. Side effects, drug interactions, warnings and precauctions, dosage, what the drug is used for, what to do if you miss a dose, how the drug is to be stored, and generic vs. brand names.
High Blood Pressure HypertensionHigh blood pressure is defined as a pressure of 140/90 mmHg or higher in the arteries. Genetic factors, high salt intake, and increased arterial stiffness cause high blood pressure. Dizziness, headache, nausea, and shortness of breath are just a few symptoms of high blood pressure. Untreated high blood pressure increases the risk of heart disease, kidney disease, atherosclerosis, eye damage, stroke, and increased risk of aneurysms. High blood pressure can be managed with weight loss, lifestyle changes, and medication.
High Blood Pressure Medication
High blood pressure (hypertension) medications include drugs from a variety of different drug classes and types.
- ACE inhibitors
- ARB (angiotensin receptor blockers)
- Beta blockers
- Calcium channel blockers (CCBs)
- Alpha-beta blockers
Clonidine (Catapres) and minoxidil also are drugs prescribed for the treatment of high blood pressure. Side effects, warnings and precautions, safety information, and pregnancy and breastfeeding safety information should be reviewed prior to taking any medication.
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High Blood Pressure TreatmentHigh blood pressure (hypertension) means high pressure (tension) in the arteries. Treatment for high blood pressure include lifestyle modifications (alcohol, smoking, coffee, salt, diet, exercise), drugs and medications such as ACE inhibitors, angiotensin receptor blockers, beta blockers, diuretics, calcium channel blockers (CCBs), alpha blockers, clonidine, minoxidil, and Exforge.
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ParathyroidectomyParathyroidectomy is the removal of one or more of the parathyroid glands to treat hyperparathyroidism. Risks of parathyroidectomy include:
- paralysis of the vocal cords,
- difficulty swallowing thin liquids,
- difficulty breathing,
- and drug reactions.
- damage to the recurrent laryngeal nerve,
- bleeding or hematoma,
- problems maintaining calcium levels in the blood,
- need for further and more aggressive surgery,
- need for a limited or total thyroidectomy,
- prolonged pain,
- impaired healing,
- and recurrence of the tumor.