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- What is amiodarone, and how does it work (mechanism of action)?
- What brand names are available for amiodarone?
- Is amiodarone available as a generic drug?
- Do I need a prescription for amiodarone?
- What are the side effects of amiodarone?
- What is the dosage for amiodarone?
- Which drugs or supplements interact with amiodarone?
- Is amiodarone safe to take if I'm pregnant or breastfeeding?
- What else should I know about amiodarone?
What is amiodarone, and how does it work (mechanism of action)?
Amiodarone is an oral and injectable drug that is used to correct abnormal rhythms of the heart. (It is an antiarrhythmic medication.) Although amiodarone has many side effects, some of which are severe and potentially fatal, it has been successful in treating many arrhythmias when other antiarrhythmic drugs have failed. Amiodarone is considered a "broad spectrum" antiarrhythmic medication, that is, it has multiple and complex effects on the electrical activity of the heart which is responsible for the heart's rhythm. Among its most important electrical effects are:
- a delay in the rate at which the heart's electrical system "recharges" after the heart contracts (repolarization);
- a prolongation in the electrical phase during which the heart's muscle cells are electrically stimulated (action potential);
- a slowing of the speed of electrical conduction (how fast each individual impulse is conducted through the heart's electrical system);
- a reduction in the rapidity of firing of the normal generator of electrical impulses in the heart (the heart's pacemaker);
- a slowing of conduction through various specialized electrical pathways (called accessory pathways) which can be responsible for arrhythmias.
In addition to being an antiarrhythmic medication, amiodarone also causes blood vessels to dilate (enlarge). This effect can result in a drop in blood pressure. Because of this effect, it also may be of benefit in patients with congestive heart failure.
Amiodarone was discovered in 1961 and approved by the FDA in December 1985.
What are the side effects of amiodarone?
Amiodarone has many side effects and several that are serious. This is only a partial list. Common side effects include:
- eye deposits,
- unsteady gait,
- weight loss,
- dizziness, and
- visual changes.
Amiodarone is also associated with:
Quick GuideHeart Disease: Symptoms, Signs, and Causes
What is the dosage for amiodarone?
The recommended dosing schedule is an initial loading dose of 800-1600 mg daily for 1 to 3 weeks, followed by 600-800 mg daily for 1 month, then 400 mg daily for maintenance. Response should be closely monitored and dosing is individualized for each patient. Amiodarone may be administered once daily or given twice daily with meals to minimize stomach upset which is seen more frequently with higher doses.
Which drugs or supplements interact with amiodarone?
Amiodarone may interact with beta-blockers such as atenolol (Tenormin), propranolol (Inderal), metoprolol (Lopressor), or certain calcium channel blockers, such as verapamil (Calan, Isoptin, Verelan, Covera-HS) or diltiazem (Cardizem, Dilacor, Tiazac), resulting in an excessively slow heart rate or a block in the conduction of the electrical impulse through the heart.
Amiodarone increases the blood levels of digoxin (Lanoxin) when the two drugs are given together. It is recommended that the dose of digoxin be cut by 50% when amiodarone therapy is started. Flecainide (Tambocor) blood concentrations increase by more than 50% with amiodarone. Procainamide (Procan-SR, Pronestyl) and quinidine (Quinidex, Quinaglute) concentrations increase by 30%-50% during the first week of amiodarone therapy. Additive electrical effects occurs with these combinations, and worsening arrhythmias may occur as a result. Some experts recommend that the doses of these other drugs be reduced when amiodarone is started. Amiodarone can result in phenytoin (Dilantin) toxicity because it causes a two- or three-fold increase in blood concentrations of phenytoin. Symptoms of phenytoin toxicity including unsteady eye movement (temporary and reversible), tiredness and unsteady gait.
Ritonavir (Norvir), tipranavir (Aptivus), indinavir (Crixivan), and saquinavir (Invirase) can inhibit the enzyme that is responsible for the metabolism (break-down) of amiodarone. They should not be combined with amiodarone.
Amiodarone also can interact with tricyclic antidepressants (for example, amitriptyline [Endep, Elavil]), or phenothiazines (for example, chlorpromazine [Thorazine]) and potentially cause serious arrhythmias.
Amiodarone interacts with warfarin (Coumadin) and increases the risk of bleeding. The bleeding can be serious or even fatal. This effect can occur as early as 4-6 days after the start of the combination of drugs or can be delayed by a few weeks. Clotting studies probably should be done early during treatment with amiodarone among patients taking warfarin.
Amiodarone can interact with some cholesterol-lowering medicines of the statin class, such as simvastatin (Zocor), atorvastatin (Lipitor), and lovastatin (Mevacor), increasing the side effects of statins which include severe muscle breakdown, kidney failure or liver disease. This interaction is dose-related, meaning that lower doses of statins are safer than higher doses when used with amiodarone. An alternative statin, pravastatin (Pravachol), does not share this interaction and is safer in patients taking amiodarone.
Amiodarone inhibits the metabolism of dextromethorphan, the cough suppressant found in most over-the-counter (and some prescription) cough and cold medications (for example, Robitussin-DM). Although the significance of the interaction is unknown, these two drugs probably should not be taken together if possible.
Grapefruit juice may reduce the breakdown of amiodarone in the stomach leading to increased amiodarone blood levels. Grapefruit juice should be avoided during treatment with amiodarone.
Is amiodarone safe to take if I'm pregnant or breastfeeding?
Amiodarone should not be used during pregnancy because it can cause fetal harm. There have been reports of congenital hypothyroidism or hyperthyroidism when amiodarone was administered during pregnancy.
Amiodarone is excreted in breast milk and may cause adverse effects in the infant. Breastfeeding should be discontinued by mothers receiving amiodarone.
What else should I know about amiodarone?
What preparations of amiodarone are available?
Tablets: 100, 200 mg. Injection: 50 mg/ml., 1.5 g/ml., 1.8 g/ml.
How should I keep amiodarone stored?
Tablets and injection should be kept at room temperature, 20 C to 25 C (68 F to 77 F).
Amiodarone (Cordarone, Nextrone, Pacerone) is an oral and injectable medication prescribed to correct abnormal rhythms of the heart. Side effects, drug interactions (an extensive list), warnings and precautions, and pregnancy efficacy should be reviewed prior to taking any medication.
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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Congestive Heart Failure (CHF) OverviewCongestive heart failure (CHF) refers to a condition in which the heart loses the ability to function properly. Heart disease, high blood pressure, diabetes, myocarditis, and cardiomyopathies are just a few potential causes of congestive heart failure. Signs and symptoms of congestive heart failure may include fatigue, breathlessness, palpitations, angina, and edema. Physical examination, patient history, blood tests, and imaging tests are used to diagnose congestive heart failure. Treatment of heart failure consists of lifestyle modification and taking medications to decrease fluid in the body and ease the strain on the heart. The prognosis of a patient with congestive heart failure depends on the stage of the heart failure and the overall condition of the individual.
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Palpitations OverviewPalpitations are uncomfortable sensations of the heart beating hard, rapidly, or irregularly. Some types of palpitations are benign, while others are more serious. Palpitations are diagnosed by taking the patient history and by performing an EKG or heart monitoring along with blood tests. An electrophysiology study may also be performed. Treatment of palpitations may include lifestyle changes, medication, ablation, or implantation of a pacemaker. The prognosis if palpitations depends on the underlying cause.
Paroxysmal Supraventricular Tachycardia (PSVT)Paroxysmal supraventricular tachycardia (PSVT) is an abnormal conduction of electricity in particular areas of the heart. PSVT was referred to at one time as paroxysmal atrial tachycardia or PAT, however, the term PAT is reserved for as specific heart condition. Symptoms of PSVT include weakness, shortness of breath, chest pressure, lightheadedness, and palpitations. PSVT is treated with medications or procedures that return the heart to its normal electrical pattern.
Periodic Paralysis Syndrome
Periodic paralysis syndrome comprises several types of rare muscle diseases in which a person experiences temporary muscle paralysis of one area of the body, or the entire body for a few minutes or days. The person regains normal muscle strength between periods of muscle weakness. You inherit the syndrome from your biological mother or father, or from a mutation in your genes. This gene mutation determines the type of periodic paralysis you have. The other symptoms depend upon the type of periodic paralysis you have.
- Hyperkalemic periodic paralysis is usually seen in children under the age of 10. An early symptom may be a lagging eyelid.
- Normokalemic periodic paralysis causes weakness.
- Hypokalemia periodic paralysis 1 or hypoPP1L usually begins in childhood with symptoms of episodic muscle weakness in addition to irregular heartbeats. The symptoms may last through age 20-40.
- Hypokalemia periodic paralysis 2 or hypoPP2 has the same signs and symptoms as hypoPP1.
- Thyrotoxic periodic paralysis or TPP causes symptoms of weakness that involves the muscles that help you breathe.
- Paramyotonia Congenita or PCM produces symptoms like a weakness response to cold or increased activity and muscle weakness and rigidity.
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- Andersen-Tawil syndrome or ATS cause symptoms of irregular heart rhythms.
- Familial periodic paralysis is a term used by doctors to describe four of the periodic paralysis syndromes.
Treatment of periodic paralysis syndrome depends upon the kind of syndrome you have. Your doctor may make changes to your diet and prescribe prescription medication.
REFERENCE: Stripathi, N., MD. "Periodic paralyses." Medscape. Updated: May 18, 2017.
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