What is Amikacin sulfate?

Amikacin sulfate injection is an aminoglycoside antibiotic used to treat infections caused by gram-negative bacteria such as: 

  • Pseudomonas species,
  • Escherichia coli,
  • Providencia species,
  • Indole-positive and indole-negative Proteus species,
  • Klebsiella-Enterobacter-Serratia species,
  • and Acinetobacter.

Amikacin is also used in certain staphylococcal infections as well. 

Amikacin binds to components of bacteria that produce important bacterial proteins, blocking protein synthesis which eventually leads to stopping further bacterial growth. Amikacin is used to treat infections caused by bacteria that are resistant to gentamicin and tobramycin. 

Common side effects of amikacin sulfate injection include:

Serious side effects of amikacin sulfate injection include:

  • hearing loss and kidney dysfunction for individuals treated with high doses or for longer periods.

Drug interactions of amikacin sulfate injection include: 

  • amphotericin due to significant risk of loss of hearing and severe kidney dysfunction,
  • and due to high risk of loss of hearing and kidney dysfunction, Amikacin should be used with great caution with medications like: 

Amikacin is harmful to the fetus and should not be used during pregnancy unless there are not safer options. It is unknown if Amikacin enters breast milk. Use caution while breastfeeding.

What are the important side effects of Amikacin sulfate?

Side effects of Amikacin are:

Amikacin carries a boxed warning of loss of hearing and kidney dysfunction for individuals treated with high doses or for longer periods.

Amikacin sulfate side effects list for healthcare professionals

All aminoglycosides have the potential to induce auditory, vestibular, and renal toxicity and neuromuscular blockade. They occur more frequently in patients with present or past history of renal impairment, of treatment with other ototoxic or nephrotoxic drugs, and in patients treated for longer periods and/or with higher doses than recommended.

Neurotoxicity-Ototoxicity

Toxic effects on the eighth cranial nerve can result in hearing loss, loss of balance, or both. Amikacin primarily affects auditory function. Cochlear damage includes high frequency deafness and usually occurs before clinical hearing loss can be detected.

Neurotoxicity-Neuromuscular Blockade

Acute muscular paralysis and apnea can occur following treatment with aminoglycoside drugs.

Nephrotoxicity

Elevation of serum creatinine, albuminuria, presence of red and white cells, casts, azotemia, and oliguria have been reported. Renal function changes are usually reversible when the drug is discontinued. As would be expected with any aminoglycoside, reports of toxic nephropathy and acute renal failure have been received during postmarketing surveillance.

Other

In addition to those described above, other adverse reactions which have been reported on rare occasions are:

Macular infarction sometimes leading to permanent loss of vision has been reported following intravitreous administration (injection into the eye) of amikacin.

What drugs interact with Amikacin sulfate?

No information provided.

Summary

Amikacin sulfate injection is an aminoglycoside antibiotic used to treat infections caused by gram-negative bacteria such as Pseudomonas species, Escherichia coli, Providencia species, Indole-positive and indole-negative Proteus species, Klebsiella-Enterobacter-Serratia species, and Acinetobacter. Amikacin is also used in certain staphylococcal infections as well. Common side effects of amikacin sulfate injection include loss of balance, muscular paralysis, fever, rash, headache, and low blood pressure. Amikacin is harmful to the fetus and should not be used during pregnancy unless there are not safer options. It is unknown if Amikacin enters breast milk. Use caution while breastfeeding.

Treatment & Diagnosis

Medications & Supplements

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Medically Reviewed on 3/18/2020
References
FDA Prescribing Information