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What is Amikacin sulfate?
Amikacin sulfate injection is an aminoglycoside antibiotic used to treat infections caused by gram-negative bacteria such as:
- Pseudomonas species,
- Escherichia coli,
- Providencia species,
- Indole-positive and indole-negative Proteus species,
- Klebsiella-Enterobacter-Serratia species,
- and Acinetobacter.
Amikacin is also used in certain staphylococcal infections as well.
Amikacin binds to components of bacteria that produce important bacterial proteins, blocking protein synthesis which eventually leads to stopping further bacterial growth. Amikacin is used to treat infections caused by bacteria that are resistant to gentamicin and tobramycin.
Common side effects of amikacin sulfate injection include:
Serious side effects of amikacin sulfate injection include:
- hearing loss and kidney dysfunction for individuals treated with high doses or for longer periods.
Drug interactions of amikacin sulfate injection include:
- amphotericin due to significant risk of loss of hearing and severe kidney dysfunction,
- and due to high risk of loss of hearing and kidney dysfunction, Amikacin should be used with great caution with medications like:
What are the important side effects of Amikacin sulfate?
Side effects of Amikacin are:
- hearing loss,
- kidney dysfunction,
- loss of balance,
- muscular paralysis,
- headache, and
- low blood pressure.
Amikacin carries a boxed warning of loss of hearing and kidney dysfunction for individuals treated with high doses or for longer periods.
Amikacin sulfate side effects list for healthcare professionals
All aminoglycosides have the potential to induce auditory, vestibular, and renal toxicity and neuromuscular blockade. They occur more frequently in patients with present or past history of renal impairment, of treatment with other ototoxic or nephrotoxic drugs, and in patients treated for longer periods and/or with higher doses than recommended.
Toxic effects on the eighth cranial nerve can result in hearing loss, loss of balance, or both. Amikacin primarily affects auditory function. Cochlear damage includes high frequency deafness and usually occurs before clinical hearing loss can be detected.
Acute muscular paralysis and apnea can occur following treatment with aminoglycoside drugs.
Elevation of serum creatinine, albuminuria, presence of red and white cells, casts, azotemia, and oliguria have been reported. Renal function changes are usually reversible when the drug is discontinued. As would be expected with any aminoglycoside, reports of toxic nephropathy and acute renal failure have been received during postmarketing surveillance.
In addition to those described above, other adverse reactions which have been reported on rare occasions are:
- skin rash,
- drug fever,
- nausea and vomiting,
- and hypomagnesemia.
Macular infarction sometimes leading to permanent loss of vision has been reported following intravitreous administration (injection into the eye) of amikacin.
Amikacin sulfate injection is an aminoglycoside antibiotic used to treat infections caused by gram-negative bacteria such as Pseudomonas species, Escherichia coli, Providencia species, Indole-positive and indole-negative Proteus species, Klebsiella-Enterobacter-Serratia species, and Acinetobacter. Amikacin is also used in certain staphylococcal infections as well. Common side effects of amikacin sulfate injection include loss of balance, muscular paralysis, fever, rash, headache, and low blood pressure. Amikacin is harmful to the fetus and should not be used during pregnancy unless there are not safer options. It is unknown if Amikacin enters breast milk. Use caution while breastfeeding.
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Related Disease Conditions
Upper Respiratory Tract Infection (URTI)
An upper respiratory infection is a contagious infection of the structures of the upper respiratory tract, which includes the sinuses, nasal passages, pharynx, and larynx. Common causes of an upper respiratory infection include bacteria and viruses such as rhinoviruses, group A streptococci, influenza, respiratory syncytial, whooping cough, diphtheria, and Epstein-Barr. Examples of symptoms of upper respiratory infection include sneezing, sore throat, cough, fever, and nasal congestion. Treatment of upper respiratory infections are based upon the cause. Generally, viral infections are treated symptomatically with over-the-counter (OTC) medication and home remedies.
Inner Ear Infection (Symptoms, Signs, Treatments, Home Remedies)
An inner ear infection or otitis interna is caused by viruses or bacteria and can occur in both adults and children. An inner ear infection can cause symptoms and signs, for example, a severe ear, dizziness, vertigo, nausea and vomiting, and vertigo. An inner ear infection also may cause inflammation of the inner ear or labyrinthitis. Inner ear infections are not contagious; however, the bacteria and viruses that cause the infection can be transmitted to other people. Good hygiene practices will help decrease the chances of the infection spreading to others. Inner ear infection symptoms and signs like ear pain and nausea may be relieved with home remedies or over the counter (OTC) medication. Some inner ear infections will need to be treated and cured with antibiotics or prescription pain or antinausea medication.
Staph Infection (Staphylococcus Aureus)
Staphylococcus or staph is a group of bacteria that can cause a multitude of diseases. Staph infections can cause illness directly by infection or indirectly by the toxins they produce. Symptoms and signs of a staph infection include redness, swelling, pain, and drainage of pus. Minor skin infections are treated with an antibiotic ointment, while more serious infections are treated with intravenous antibiotics.
Vaginal Yeast Infection (in Women and Men)
Vaginal yeast infections in women are caused by an organism called Candida albicans. Symptoms of a vaginal yeast infection include vaginal pain with urination, vaginal discharge, odor, and itching. Treatment is generally OTC medications. A man can contract a yeast infection from his female sexual partner. Symptoms of a yeast infection in men include penile itching. Treatment is with oral or topical medication.
Cold Sores (Nongenital Herpes Simplex Infections)
Herpes simplex infections are common and when they appear around the mouth and lips, people often refer to them as "cold sores" and "fever blisters." Canker sores are different than cold sores. Air droplets can spread the virus, as can direct contact with the fluid from the blisters. Cold sore treatment include over-the-counter medication, as well as prescription medications.
Urinary Tract Infection (UTI)
A urinary tract infection (UTI) is an infection of the bladder, kidneys, ureters, or urethra. E. coli, a type of bacteria that lives in the bowel and near the anus, causes most UTIs. UTI symptoms include pain, abdominal pain, mild fever, urinary urgency and frequency. Treatment involves a course of antibiotics.
H. pylori (Helicobacter Pylori) Infection
Helicobacter pylori (H. pylori) is a bacteria that causes chronic inflammation (gastritis) of the inner lining of the stomach, and also is the most common cause of ulcers worldwide. About 50% of people in the world carries or is infected with H. pylori. Common symptoms of H. pylori infection are occasional abdominal discomfort, bloating, belching or burping, and nausea and vomiting. H. pylori infection is difficult to eradicate, and treatment is with two or more antibiotics.
Genital Warts (HPV) Infection in Women
Genital warts is a sexually transmitted infection (STI, STD) caused by the human papillomavirus (HPV). It is the most common STD in the US. The warts can appear anywhere on the skin where sexual contact has occurred. The warts look like raised, flesh-colored lumps or bumps that have a cauliflower-like appearance. Signs and symptoms of genital warts in women include vaginal, vulva, or groin pain, itching, and burning where the wart(s) is. Treatment can remove warts or lesions, but it does not prevent spread of the virus, and the warts usually grow back. Removing genital warts does not prevent the infection from spreading elsewhere on the body. There is no cure for genital warts, and there is no vaccine to prevent them; however, there is a vaccine to prevent infection from four common types of HPV. Gardasil vaccine available for female adolescents and teens to prevent HPV infection and cervical cancer.
MRSA (methicillin-resistant Staphylococcus aureus) bacteria causes skin infections with the following signs and symptoms: cellulitis, abscesses, carbuncles, impetigo, styes, and boils. Normal skin tissue doesn't usually allow MRSA infection to develop. Individuals with depressed immune systems and people with cuts, abrasions, or chronic skin disease are more susceptible to MRSA infection.
E. coli (0157:H7) Infection
There are many types of E. coli (Escherichia coli). E. coli can cause urinary tract and bladder infections, or lead to sepsis. E coli O157:H7 (EHEC) causes bloody diarrhea and colitis. Complications of E. coli infection include hemorrhagic diarrhea, hemolytic-uremic syndrome, and thrombotic thrombocytopenic purpura. Symptoms include severe abdominal pain and bloody diarrhea. E coli O157:H7 commonly is due to eating raw or undercooked hamburger or raw milk or dairy products.
Ear Infection Home Treatment
Infections of the outer, middle, and inner ear usually are caused by viruses. Most outer (swimmer's ear) and middle ear (otitis media) infections can be treated at home with remedies like warm compresses for ear pain relief, tea tree, ginger, or garlic oil drops. Symptoms of an outer ear (swimmer's ear) and middle ear infection include mild to severe ear pain, pus draining from the ear, swelling and redness in the ear, and hearing problems. Middle and inner ear infections may cause fever, and balance problems. Inner ear infections also may cause nausea, vomiting, vertigo, ringing in the ear, and labyrinthitis (inflammation of the inner ear). Most outer and middle ear infections do not need antibiotics. Inner ear infections should be treated by a doctor specializing in ear and hearing problems.
Amebiasis (Entamoeba Histolytica Infection)
Amebiasis is an infection caused by an amoeba. Signs and symptoms include bloody stools, abdominal pain, weight loss, fever, and gas. Treatment may involve taking luminal agents or antibiotics. Surgery may be indicated for various reasons.
Yeast infections vs. STDs in Men and Women
Kidney Infection (Pyelonephritis)
Kidney infection (pyelonephritis) usually is caused by E. coli and other bacteria that have spread from the bladder from a UTI (urinary tract infection), poor hygiene, sexual intercourse, pregnancy, catheter, cystoscope exam, surgery, kidney stones, or prostate enlargement. Symptoms of kidney infection include back pain, frequent urination, pain during urination, fever, and or pus or blood in the urine. Kidney infection can be cured with antibiotic treatment. Cranberry juice may prevent UTIs, but that hasn’t been proven in all research studies.
Is MRSA Contagious?
MRSA stands for methicillin-resistant Staphylococcus aureus. MRSA typically spreads through person-to-person contact, but it can also spread via aerosolized droplets. A MRSA skin infection will rapidly become painful, swollen, drain pus, and be warm to the touch.
Is a Staph Infection Contagious?
A staph infection is caused by the bacteria Staphylococcus aureus. Staph can cause boils, food poisoning, cellulitis, toxic shock syndrome, MRSA, and various other illnesses and infections. Most staph infections are transmitted from person to person.
Group A streptococcal infections are caused by group A streptococcus, a bacteria that causes a variety of health problems, including strep throat, impetigo, cellulitis, erysipelas, and scarlet fever. There are more than 10 million group A strep infections each year.
Urinary Tract Infections in Children
Urinary tract infections (UTIs) are very common in children. Symptoms and signs include fever and abdominal pain. Associated symptoms and signs include flank pain, vomiting, and blood in the urine. Treatment for a UTI involves antibiotic therapy.
Is a Sinus Infection Contagious?
Sinus infection (sinusitis) is infection (viral, bacterial, or fungal) or inflammation of the sinuses. Symptoms of sinus infection are cough, bad breath, coughing up greenish-yellow sputum, sinus headache, and other symptoms of the common cold. Treatments of sinus infection are home remedies to soothe symptoms and antibiotics if the infection is bacterial or fungal.
Is a Yeast Infection Contagious?
Yeast are a fungi that has many types. A type of yeast that can cause infection in humans is called Candida. Candida can infect the mouth, vagina, penis, or other areas of the body. Symptoms of yeast infections depend on the area infected, however, may include itching, bumps on the skin, a reddish rash, or patches of skin that ooze a clear or yellow liquid. Most yeast infections are not contagious even though they are caused by a fungus.
Is a Urinary Tract Infection (UTI) Contagious?
Bacteria such as E. coli or Pseudomonas can cause a urinary tract infection (UTI). The incubation period for a UTI ranges from three to eight days.
Bladder Infection (Cystitis)
Bladder infection is an infection of the bladder, usually caused by bacteria or, rarely, by Candida. Certain people, including females, the elderly, men with enlarged prostates, and those with chronic medical conditions are at increased risk for bladder infection. Bladder infections are treated with antibiotics, but cranberry products and adequate hydration may help prevent bladder infections.
Yeast Infection vs. Bacterial Vaginosis (BV)
Yeast infections and bacterial vaginosis (BV) both cause vaginal discharge. Yeast infection discharge is thick, white, and had a cottage cheese consistency. BV discharge is whitish-gray and is thinner. Vaginal odor, irritation, and pain may also be present. Treatment of yeast infections includes over-the-counter and prescription antifungals. BV treatment involves antibiotics.
Second Source article from Government
Urinary Tract Infection in Adults
Second Source article from Government
Herpes Viral Infections of the Eye
Herpes of the eye occurs due to herpes simplex virus-1 (HSV-1). Symptoms of herpes of the eye include pain in and around the eye, rash or sores on the eyelids, redness, swelling, and cloudiness of the cornea.
Second Source article from Government
Yeast Infection vs. Urinary Tract Infection (UTI)
Candida albicans typically causes vaginal yeast infections. Bacterial infections typically cause urinary tract infections (UTIs). Thick white cottage-cheese like vaginal discharge characterizes vaginal yeast infections. Painful, frequent urination characterize urinary tract infections. Antifungal medications treat yeast infections while prescription antibiotics treat UTIs.
Yeast Infection vs. Diaper Rash in Infants, Toddlers, and Children
Diaper rash in infants, babies, toddlers, and children is caused by Candida, the most common type of fungus. Signs and symptoms of diaper rash is red, elevated skin that may be visible under and in the creases of the skin, groin, or anus. Yeast diaper rash is not painful. Treatments for diaper rash include antibiotic creams, lotions, natural home remedies, over-the-counter (OTC) medicine, and oral antibiotics. Yeast infections in infants, babies, toddlers, and children can cause diaper rash, thrush. Signs and symptoms of thrush include thick, white lacy patches on top of a red base can form on the tongue, palate, or elsewhere inside the palate. Treatment for yeast infections caused by Candida fungi are similar to the treatments for diaper rash. If Candida gets into the blood stream of an individual they may get sick with or without a fever. If the Candida infection spreads throughout the body up to 45% of people may die. Even with common mouth thrush can cause critical illness and may be more resistant to normal treatment.
Sinus Infection vs. Allergies
Both sinus infections and allergies (allergic rhinitis) cause symptoms such as runny or stuffy nose and fatigue. Sinus infection (known as sinusitis) is inflammation of the sinuses, caused by infection from bacteria, viruses, and/or fungi (molds). Allergic rhinitis occurs when certain allergies cause nasal symptoms. When a person with allergies breathes in an allergen, such as pollen, dust, or animal dander, symptoms such as runny or stuffy nose, itching, sneezing, and fatigue occur.
Vibrio Infection (Vibriosis)
Vibrio bacteria thrive in warm coastal waters and cause illness when people eat undercooked shellfish or when brackish or saltwater comes in contact with an open wound. Treatment involves drinking plenty of liquid.
Sinus Infection vs. Cold
Viruses cause the common cold and most sinus infections. Bacterial and fungal infections may also cause a sinus infection. Signs and symptoms of colds and sinus infections include nasal irritation or dryness, sore throat, stuffy nose, nasal discharge/congestion, sneezing, and cough. Additional symptoms of sinus infections include sinus pressure behind the cheeks or eyes, facial pain when pressure is applied, bad breath, and thick yellow or green mucus. Treatment focuses on symptom relief.
Aspergillus Infection (Aspergillosis)
An Aspergillus infection is a fungal infection. Signs and symptoms can include cough, shortness of breath, wheezing, bloody sputum, difficulty breathing, and chest and/or joint pain. Treatment depends on the type and severity of the disease.
Treatment & Diagnosis
- Bladder Infection
- Urinary Tract Infection (UTI)
- Vaginal Yeast Infection
- HIV Infection
- Upper Respiratory Infection
- Sinus Infection (Sinusitis)
- Middle Ear Infection (Otitis Media)
- Kidney Infection (Pyelonephritis)
- Helicobacter pylori (H. pylori) Infection
- MRSA Infection
- Zika Virus Infection
- Inner Ear Infection (Otitis Interna)
- Giardiasis (Giardia Lamblia Infection)
- Cytomegalovirus (CMV) Infection
- E. coli 0157:H7 (Escherichia coli 0157:H7)
- Respiratory Syncytial Virus (RSV) Infection
- Enterovirus (Non-Polio Enterovirus Infection)
- Rotavirus Infection
- Urinary Tract Infections in Children
- Urinary Tract Infection FAQs
- Yeast Infection FAQs
- MRSA FAQs
- Strep Streptococcal Throat Infection FAQs
- Ear Infection FAQs
- Heart Attacks caused by Infections?
- Is It Easier to Get Staph Infection When You've Had it Before?
- What Causes Yeast Infections (Vaginitis)?
- What Is the Difference Between a Bladder Infection vs. UTI?
- How Do You Get Staph Infection?
- What Causes an Ear Infection?
- How Do You Get an Ear Infection?
- How to Get Rid of a Staph Infection
- Is there Over-the-Counter Ear Infection Medicine?
- Flesh Eating Bacterial Infection
- Urinary Tract Infection (UTI) Symptoms
- Superbug Staph (MRSA) Spread in Community
- E. coli Infection Facts
- Urinary Tract Infection (UTI) Treatment
- Air Travel, Colds, and Sinus Infections
Medications & Supplements
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.