- What other names is Alpha-linolenic Acid known by?
- What is Alpha-linolenic Acid?
- How does Alpha-linolenic Acid work?
- Are there safety concerns?
- Dosing considerations for Alpha-linolenic Acid.
flaxseed (linseed) oil, canola (rapeseed) oil, and soybean oil, as well as in red meat and dairy products.
Alpha-linolenic acid is popular for preventing and treating diseases of the heart and blood vessels. It is used to prevent heart attacks, lower high blood pressure, lower cholesterol, and reverse "hardening of the blood vessels" (atherosclerosis). There is some evidence that alpha-linolenic acid from dietary sources might be effective for all these uses except lowering cholesterol. Not enough is known yet to be able to rate alpha-linolenic acid's effect on high cholesterol.
Alpha-linolenic acid is used to treat rheumatoid arthritis (RA), multiple sclerosis (MS), lupus, diabetes, renal disease, ulcerative colitis, and Crohn's disease. It is also used to prevent pneumonia.
Other uses include treatment of chronic obstructive pulmonary disease (COPD), migraine headache, skin cancer, depression, and allergic and inflammatory conditions such as psoriasis and eczema.
Some people use alpha-linolenic acid to prevent cancer. Ironically, alpha-linolenic acid may actually raise some men's risk of getting prostate cancer.
You have probably heard a lot about other omega-3 fatty acids such as EPA and DHA, which are found in fish oil. Be careful. Not all omega-3 fatty acids act the same way in the body. Alpha-linolenic acid may not have the same benefits as EPA and DHA.
Possibly Effective for...
- Reducing the risk of hardening of the arteries (atherosclerosis). High dietary intake of alpha-linolenic acid seems to reduce the "plaque" in arteries serving the heart. Plaque is the fatty build-up that characterizes atherosclerosis.
- Reducing the risk of heart disease and heart attacks. High DIETARY intake of alpha-linolenic acid over a period of 6 years seems to reduce the risk of a first heart attack by as much as 59% in both men and women. Increasing DIETARY intake of alpha-linolenic acid by 1.0-1.2 grams per day appears to decrease the risk of death due to heart disease by 20% or more in people with or without existing heart disease. It is not known if alpha-linolenic acid supplements have these same benefits. Some research suggests alpha-linolenic acid has a greater effect on coronary heart disease when intake of fish oils is low.
- High blood pressure. Eating a diet high in alpha-linolenic acid seems to reduce risk of hypertension by about a third.
- Pneumonia. Eating a diet high in alpha-linolenic acid seems to reduce the risk of getting pneumonia.
Insufficient Evidence to Rate Effectiveness for...
- Prostate cancer. There is contradictory evidence about the role of alpha-linolenic acid in prostate cancer. Some research suggests that high dietary intake of alpha-linolenic acid might increase the risk of getting prostate cancer. But other research finds no increased risk or even a slight decreased risk. Reasons for the conflicting results are not clear, but the source of alpha-linolenic acid seems to be important. Alpha-linolenic acid from dairy and meat sources has been positively associated with prostate cancer. Alpha-linolenic acid from plant sources, such as flaxseed, does not appear to affect prostate cancer risk.
- Lung infections in children. Preliminary clinical research suggests that alpha-linolenic acid, in combination with linoleic acid, might reduce the number of respiratory infections in children.
- Crohn's disease..
- High cholesterol.
- Kidney disease.
- Multiple sclerosis.
- Rheumatoid arthritis (RA).
- Skin diseases.
- Systemic lupus erythematosus (SLE).
- Other conditions.
Quick GuideHeart Disease: Symptoms, Signs, and Causes
weight gain if consumed in excess.
Special Precautions & Warnings:Pregnancy and breast-feeding: Alpha-linolenic acid is LIKELY SAFE in amounts found in food. But not enough is known about the safety of alpha-linolenic acid during pregnancy and breast-feeding when used in higher amounts than those typically found in foods. Stay on the safe side and avoid using alpha-linolenic acid supplements.
High levels of blood fats called triglycerides: Don't take alpha-linolenic acid supplements if you have high levels of triglycerides. Alpha-linolenic acid might make the condition worse.
Prostate cancer. Do not take alpha-linolenic acid supplements if you have prostate cancer or are at high risk for getting prostate cancer (e.g., you have a father or brother with prostate cancer). There is some evidence that alpha-linolenic acid might increase the chance of getting prostate cancer.
- For prevention of coronary heart disease and related events like chest pain or a heart attack: Approximately 1.2-2 grams per day from dietary sources seems to be associated with the greatest benefit.
- For prevention of a second heart attack or other second event in people with coronary heart disease: Approximately 1.6 grams per day as part of a Mediterranean diet appears to be beneficial.
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).
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