- Osteoporosis Slideshow Pictures
- Super Foods for Your Bones Slideshow Pictures
- Take the Osteoporosis Quiz
- What is alendronate, and how does it work (mechanism of action)?
- What brand names are available for alendronate?
- Is alendronate available as a generic drug?
- Do I need a prescription for alendronate?
- What are the uses for alendronate?
- What are the side effects of alendronate?
- What is the dosage for alendronate?
- Which drugs or supplements interact with alendronate?
- Is alendronate safe to take if I'm pregnant or breastfeeding?
- What else should I know about alendronate?
What is alendronate, and how does it work (mechanism of action)?
Alendronate is in a class of medications called bisphosphonates. The bisphosphonate class includes etidronate (Didronel), ibandronate (Boniva), pamidronate (Aredia), risedronate (Actonel), and tiludronate (Skelid). Bisphosphonates are used for treating osteoporosis (reduced density of bone that leads to fractures) and bone pain from diseases such as metastatic breast cancer, multiple myeloma, and Paget's disease. Bone is in a constant state of remodeling. New bone is laid down by cells called osteoblasts while old bone is removed by cells called osteoclasts. Bisphosphonates strengthen bone by inhibiting bone removal (resorption) by osteoclasts. After menopause, there is an increased rate of bone loss leading to osteoporosis, and alendronate has been shown to increase bone density and decrease fractures of bones. The FDA approved alendronate in September 1995.
What are the uses for alendronate?
Alendronate is used for treating osteoporosis in men and postmenopausal women. It also is used for Paget's disease of bone and osteoporosis caused by steroid treatment. Non-FDA approved (off-label) uses include vitamin D overdose and osteoporosis caused by spinal injury.
What are the side effects of alendronate?
The most common side effect of alendronate is stomach pain.,
Other important side effects are:
Quick GuideWhat Is Osteoporosis? Treatment, Symptoms, Medication
What is the dosage for alendronate?
The recommended dose for treatment of osteoporosis is 5-10 mg daily or 35-70 mg weekly. Paget's disease is treated with 40 mg once daily for six months.
Since food, other medications, and vitamins can interfere with the absorption of alendronate, they should be taken at least 30 minutes before alendronate. In order to avoid chemical irritation of the esophagus (the swallowing tube that connects the mouth with the stomach), alendronate should be taken with a full glass of plain water immediately upon arising in the morning and never chewed or sucked. It should be avoided by patients with abnormalities of the esophagus which delay esophageal emptying, such as scarring (stricture) or poor motility (achalasia). Patients should also not lie down for 30 minutes after swallowing the tablets. Those patients who are unable to remain upright for at least 30 minutes after taking alendronate should not take it.
Which drugs or supplements interact with alendronate?
Calcium supplements and antacids reduce the absorption of alendronate. Therefore, alendronate should be taken at least 30 minutes before calcium and antacids.
Is alendronate safe to take if I'm pregnant or breastfeeding?
Alendronate has not been studied in pregnant women.
It is not known whether alendronate is secreted in human milk.
What else should I know about alendronate?
What preparations of alendronate are available?
Tablets: 5, 10, 35, 40, 70 mg. Solution: 70 mg
How should I keep alendronate stored?
Tablets and solution should be stored at room temperature, 15 C - 30 C (59 F - 86 F) and not frozen.
Alendronate (Fosamax) is in a drug class of medications called bisphosphonates. Fosamax is prescribed for treating osteoporosis, bone pain from diseases such as breast cancer, multiple myeloma, and Paget's disease. Dosing, side effects, warnings and precautions, and safety during pregnancy should be reviewed prior to taking this medication.
Multimedia: Slideshows, Images & Quizzes
Menopause Quiz: Symptoms & Signs
The Menopause Quiz challenges your knowledge about the time in a woman’s life when menstruation ceases. Menopause can bring many...
Osteoporosis Quiz: What is Osteoporosis?
What are the causes, symptoms, and risk factors of osteoporosis? Quiz yourself about vitamin deficiency, maintaining bone...
Picture of Osteoporosis
Thinning of the bones with reduction in bone mass due to depletion of calcium and bone protein. See a picture of Osteoporosis and...
Related Disease Conditions
Menopause is the time in a woman's life when menstrual periods permanently stop, also called the "change of life." Menopause...
Learn about osteoporosis, a condition characterized by the loss of bone density, which leads to an increased risk of bone...
Osteopenia is a bone condition characterized by bone loss that is not as severe as in osteoporosis. Bone fracture is the typical...
Breast cancer is an invasive tumor that develops in the mammary gland. Breast cancer is detected via mammograms, breast...
Multiple myeloma is a form of cancer that develops in plasma cells, the white blood cells that make antibodies. Symptoms include...
Paget's disease is a chronic bone disorder due to irregular breakdown and formation of bone tissue. Symptoms of Paget's disease...
Broken Bone (Types of Bone Fractures)
A broken bone is a fracture. There are different types of fractures, such as: compressed, open, stress, greenstick,...
Giant Cell Arteritis (GCA or Temporal Arteritis)
Giant cell arteritis, inflammation of blood vessel walls, affects 10%-15% of polymyalgia rheumatica patients. Symptoms of giant...
Disease Prevention in Women
Disease prevention in women includes screening tests that are a basic part of prevention medicine. All screening tests are...
Treatment & Diagnosis
- Menopause FAQs
- Osteoporosis FAQs
- Drugs: Buying Prescription Drugs Online Safely
- Osteoporosis - EVISTA..... Wellness for Women?
- Osteoporosis Prevention & Treatment
- Osteoporosis Prevention & Treatment - Exercise & Estrogen
- Osteoporosis Prevention & Treatment - Medications, Fluoride, Monitoring
- Prescriptions: Complying with the Doctor's Orders
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Medication Disposal
- Dangers of Mixing Medications
- Drugs: The Most Common Medication Errors
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
Prevention & Wellness
- Over 100 Drugs Pose Risk to Heart Failure Patients
- Osteoporosis Drugs Work, But Review Finds No Clear Winner
- Bone Drugs Don't Lower Breast Cancer Risk After All, Study Finds
- Novel Osteoporosis Drug Could Change Treatment: Study
- Osteoporosis Drugs' Safety Subject of FDA Panel
- New Evidence of Fracture Risk From Bone Drugs
- Osteoporosis Drugs Linked to Rare Fractures
- Osteoporosis Drugs May Be Linked to Cancer Risk
- Only Rare Fractures Linked to Osteoporosis Drugs
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Top alendronate Related Articles
Breast Cancer (Facts, Stages)Breast cancer is an invasive tumor that develops in the mammary gland. Breast cancer is detected via mammograms, breast self-examination (BSE), biopsy, and specialized testing on breast cancer tissue. Treatment of breast cancer may involve surgery, radiation, hormone therapy, chemotherapy, and targeted therapy. Breast cancer risk may be lowered by managing controllable risk factors.
Broken Bone (Types of Bone Fractures)
A broken bone is a fracture. There are different types of fractures, such as:
- vertebral compression,
- compound, and
Symptoms of a broken bone include pain at the site of injury, swelling, and bruising around the area of injury. Treatment of a fracture depends on the type and location of the injury.
Disease Prevention in WomenDisease prevention in women includes screening tests that are a basic part of prevention medicine. All screening tests are commonly available through your general doctor. Some specialized tests may be available elsewhere.
Drug InteractionsDrug interactions occur frequently. Get facts about the types of drug interactions, what substances or other things that may interact with drugs such as OTC drug and prescription drugs, vitamins, food(s) (grapefruit), and laboratory tests. Find out how to protect yourself from potential drug interactions.
Drugs: What You Should Know About Your DrugsImportant information about your drugs should be reviewed prior to taking any prescription drug. Side effects, drug interactions, warnings and precauctions, dosage, what the drug is used for, what to do if you miss a dose, how the drug is to be stored, and generic vs. brand names.
Didronel (etidronate) is a medication prescribed for the treatment of Paget's disease and preventing heterotopic ossification. Off-label uses include the treatment of hypercalcemia associated with cancer, prevention of postmenopausal osteoporosis and steroid induced osteoporosis. Side effects may include:
- Leg cramps
- Hair loss
Drug interactions, warnings and precautions, and pregnancy and breastfeeding safety should be reviewed prior to taking any medication.
Giant Cell Arteritis (GCA or Temporal Arteritis)
Giant cell arteritis, inflammation of blood vessel walls, affects 10%-15% of polymyalgia rheumatica patients. Symptoms of giant cell arteritis include fatigue, weight loss, low-grade fever, jaw pain when chewing, scalp tenderness, and headaches. High doses of cortisone medications are used to treat giant cell arteritis.
Boniva (ibandronate) is a medication prescribed for the treatment of osteoporosis in women after menopause. Side effects may include:
- Abdominal pain
- Back pain
- Tooth disorder
Drug interactions, warnings and precautions, and patient safety information should be reviewed prior to taking any medication.
MenopauseMenopause is the time in a woman's life when menstrual periods permanently stop, also called the "change of life." Menopause symptoms include hot flashes, night sweats, irregular vaginal bleeding, vaginal dryness, painful intercourse, urinary incontinence, weight gain, and emotional symptoms such as mood swings. Treatment of menopausal symptoms varies, and should be discussed with your physician.
Menopause QuizThe Menopause Quiz challenges your knowledge about the time in a woman’s life when menstruation ceases. Menopause can bring many physical, mental and sexual challenges to maturing women, but they don’t have to be limiting. Take the Menopause Quiz to learn the causes, symptoms and treatments of what’s known as "the change of life."
Multiple MyelomaMultiple myeloma is a form of cancer that develops in plasma cells, the white blood cells that make antibodies. Symptoms include bone pain, weakness, extreme thirst, nausea, frequent urination, and broken bones. Treatment of multiple myeloma depends upon the staging and symptoms of the disease.
OsteopeniaOsteopenia is a bone condition characterized by bone loss that is not as severe as in osteoporosis. Bone fracture is the typical symptom of osteopenia, though the condition may be present without symptoms. Treatment involves lifestyle modifications (quitting smoking, not drinking in excess) and ensuring an adequate intake of vitamin D and calcium.
OsteoporosisLearn about osteoporosis, a condition characterized by the loss of bone density, which leads to an increased risk of bone fracture. Unless one experiences a fracture, a person may have osteoporosis for decades without knowing it. Treatment for osteoporosis may involve medications that stop bone loss and increase bone strength and bone formation, as well as quitting smoking, regular exercise, cutting back on alcohol intake, and eating a calcium- and vitamin D-rich balanced diet.
Osteoporosis PictureThinning of the bones with reduction in bone mass due to depletion of calcium and bone protein. See a picture of Osteoporosis and learn more about the health topic.
Osteoporosis QuizWhat are the causes, symptoms, and risk factors of osteoporosis? Quiz yourself about vitamin deficiency, maintaining bone density, and preventing osteoporosis-related fractures.
Paget's DiseasePaget's disease is a chronic bone disorder due to irregular breakdown and formation of bone tissue. Symptoms of Paget's disease include bone pain, headaches and hearing loss, pressure on nerves, increased head size, hip pain, and damage to cartilage of joints.
Evista (raloxifene) is a medication that is prescribed for the treatment and prevention of osteoporosis in postmenopausal women. Black box warnings for Evista includes
- an increased risk of deep vein thrombosis (DVT),
- pulmonary embolism, and
Other side effects, drug interactions, dosage, and pregnancy and breastfeeding safety information should be reviewed prior to taking this medication.
Risedronate (Actonel, Actonel with Calcium, Atelvia) is a prescription medication used to treat postmenopausal osteoporosis, osteoporosis in men, and to prevent and treat osteoporosis caused by steroid medications. Common side effects include:
- Joint pain
- High blood pressure
Drug interactions, dosage, warnings and precautions, and pregnancy and breastfeeding safety should be reviewed prior to taking this medication.