What is Ajovy, and what is it used for?

Ajovy (fremanezumab-vfrm) injection is a sterile, preservative-free, clear to opalescent, colorless to slightly yellow solution for subcutaneous injection, supplied in a single-dose 225 mg/1.5 mL prefilled syringe.

Ajovy is a prescription medicine used for the preventive treatment of migraine in adults.

It is not known if Ajovy is safe and effective in children.

What are the side effects of Ajovy?

Ajovy may cause serious side effects, including:

Allergic reactions. Allergic reactions, including itching, rash, and hives, can happen within hours and up to 1 month after receiving Ajovy. Call your healthcare provider or get emergency medical help right away if you have any of the following symptoms of an allergic reaction:

  • swelling of your face, mouth, tongue, or throat
  • trouble breathing

The most common side effects of Ajovy include:

  • injection site reactions

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Ajovy. For more information, ask your healthcare provider or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the dosage for Ajovy?

  • See the detailed “Instructions for Use” for information on how to prepare and inject a dose of Ajovy.
  • Use Ajovy exactly as your healthcare provider tells you to use it.
  • Ajovy is given by injection under your skin (subcutaneously).
  • Your healthcare provider should show you or your caregiver how to prepare and inject your dose of Ajovy before you or your caregiver give your Ajovy the first time.
  • Your healthcare provider will tell you how much Ajovy to use and when to use it.
    • Your healthcare provider will tell you if you should use Ajovy 225 mg one time every month or Ajovy 675 mg one time every 3 months.
    • If your prescribed dose is Ajovy 675 mg every 3 months, you must use 3 separate syringes. You will give 3 separate injections one time every 3 months.
  • If you are giving 3 injections of Ajovy for your prescribed dose, you may use the same body site for all 3 injections, but not the same spot.
  • Do not inject Ajovy in the same injection site that you inject other medicine.
  • If you are switching from using Ajovy one time every month to one time every 3 months or if you are switching from using Ajovy one time every 3 months to one time every month, give the first dose of Ajovy on the day it was due to be given on your old schedule.
  • If you miss a dose of Ajovy, take it as soon as possible. If you need to take the dose late, you will need to adjust your schedule: if you take 225 mg of Ajovy, inject your next dose 1 month after the late dose. If you take 675 mg of Ajovy, inject your next dose 3 months after the late dose. If you have questions about your schedule, ask your healthcare provider.


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What drugs interact with Ajovy?

No information provided.

Is Ajovy safe to use while pregnant or breastfeeding?

Before you use Ajovy, tell your healthcare provider if you:

  • are pregnant or plan to become pregnant. It is not known if Ajovy will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if Ajovy passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby while using Ajovy.


Ajovy (fremanezumab-vfrm) injection is a prescription used to prevent migraines in adults. Ajovy is a monoclonal antibody made in hamster ovaries that works by inhibiting a human nerve transmitter thought to play a role in migraines. Side effects include allergic reaction.

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Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Medically Reviewed on 2/28/2020
Article content courtesy of the U.S. Food and Drug Administration