- Sexually Transmitted Diseases (STDs) Slideshow Pictures
- Image Collection: Picture of Genital Warts (HPV)
- Take the Genital Herpes Quiz
- What is acyclovir, and how does it work (mechanism of action)?
- What brand names are available for acyclovir?
- Is acyclovir available as a generic drug?
- Do I need a prescription for acyclovir?
- What are the side effects of acyclovir?
- What is the dosage for acyclovir?
- Which drugs or supplements interact with acyclovir?
- Is acyclovir safe to take if I'm pregnant or breastfeeding?
- What else should I know about acyclovir?
What is acyclovir, and how does it work (mechanism of action)?
Acyclovir is an antiviral drug, a synthetic nucleoside analogue, that has inhibitory activity (interferes with viral replication) against the herpes viruses, including herpes simplex 1 and 2 (cold sores and genital herpes), varicella-zoster (shingles and chickenpox), and Epstein-Barr virus (mononucleosis). Viruses take over living cells and reproduce themselves, often at the expense of the host cell. The acyclovir is converted to an active form by the virus itself, and the virus then uses the active form of acyclovir rather than the nucleoside it normally uses to manufacture DNA, a critical component of viral replication. Incorporation of active acyclovir into new viral DNA stops the production of the DNA. Virally infected cells absorb more acyclovir than normal cells and convert more of it to the active form, which prolongs its antiviral activity. The FDA approved acyclovir in March 1982.
What is the dosage for acyclovir?
Acyclovir may be taken with or without food.
- Adult oral doses for treating genital herpes are 200 mg every 4 hours (5 times daily) for 7-10 days or 400 mg three times daily for 5-10 days.
- Herpes Zoster (shingles) is treated with 800 mg every 4 hours (5 times daily) for 7 to 10 days.
- The dose for treating chicken pox is 800 mg 4 times daily. The usual adult intravenous dose is 5-10 mg/kg every 8 hours for 7-10 days.
Which drugs or supplements interact with acyclovir?
Acyclovir may decrease levels of phenytoin (Dilantin) or valproic acid (Depakote, Depakote ER). Probenecid (Benemid) may increase acyclovir serum levels by decreasing renal excretion of acyclovir. Acyclovir may increase serum levels of theophylline (Theo-Dur, Respbid, Slo-Bid, Theo-24, Theolair, Uniphyl, Slo-Phyllin).
Is acyclovir safe to take if I'm pregnant or breastfeeding?
There are no adequate studies of acyclovir in pregnant women. In a patient registry of women who used acyclovir during the first trimester, the rate of birth defects was similar to the rate of birth defects in the general population.
Acyclovir is excreted in breast milk, and a significant amount may be transferred to the infant.
What else should I know about acyclovir?
What preparations of acyclovir are available?
- Capsules: 200 mg.
- Tablets: 400 and 800 mg.
- Suspension: 200 mg/5 ml.
- Injection: 50 mg/ml.
- Powder for injection: 500 and 1000 mg.
- Ointment: 5%.
How should I keep acyclovir stored?
Acyclovir should be stored at room temperature, between 15 C 25 C (59 F to 77 F).
Acyclovir (Zovirax) is an antiviral drug prescribed to treat genital herpes, shingles, and chickenpox. Side effects drug interactions, dosing, storage, and pregnancy safety information should be reviewed prior to taking this medication.
Multimedia: Slideshows, Images & Quizzes
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Top acyclovir Related Articles
Chickenpox (Varicella)Chickenpox (chicken pox) is a contagious childhood disease caused by the varicella-zoster virus. Symptoms have an incubation period of 14 to 16 days and include a couple days of mild fever, weakness, and red, raised rash that progresses to blisters that eventually burst and crust over. Complications include bacterial infection of the open sores, scarring, encephalitis, nerve palsies, and Reye's syndrome.
Chickenpox QuizHow is chickenpox related to shingles? Take the Chickenpox Quiz to assess your IQ of this itchy, blistering childhood skin disease.
Cold Sores SlideshowHow to get rid of cold sores? First learn about the herpes virus and how it causes cold sores. When are cold sores contagious? Get information on triggers that can cause a flare up in cold sore symptoms.
Facial Nerve Problems
Bell's palsy is one type of facial nerve paralysis. The 7th cranial nerve controls the muscles of the face, and although scientists do not know the exact cause of Bell's palsy, they think it may be due to nerve damage from an infection, for example, the flu, common cold viruses, and more serious infections like meningitis. The symptoms of Bell's palsy vary from person to person, but can include:
- Mild weakness to total paralysis
- Dry eye
- Dry mouth
- Eyelid drooping
- Mouth drooping
- Dry mouth
- Changes in taste
- Excessive tearing in one eye
National Institute of Neurological Disorders and Stroke (NINDS). "NINDS Bell's Palsy Information Page." Updated: Apr 16, 2015.
PubMed Health. "Bell's Palsy."
NIH. National Center for Advancing Translational Sciences. "Bell's Palsy."
Genital Herpes in Women OverviewGenital herpes is a sexually transmitted disease (STD) caused by the herpes simplex virus (HSV). Symptoms of genital herpes include painful blisters and often fever, body aches, and swollen lymph nodes for first time infection. Genital herpes is diagnosed with lab tests to test for the presence of the virus. Treatment for genital herpes includes antiviral medications to shorten the duration of the outbreak or reduce the risk of future outbreaks. There is no cure for genital herpes. Condoms may help prevent the spread of genital herpes.
Genital Herpes QuizWhat is genital herpes? Learn the causes, symptoms in men and women, and treatments for this common sexually transmitted skin disease.
Herpes Simplex Infections (Non-Genital)Herpes simplex infections are common and when they appear around the mouth and lips, people often refer to them as "cold sores" and "fever blisters." Canker sores are different than cold sores. Air droplets can spread the virus, as can direct contact with the fluid from the blisters. Cold sore treatment include over-the-counter medication, as well as prescription medications.
Ramsay Hunt SyndromeRamsay Hunt syndrome is an infection of a facial nerve that causes a red painful rash with blisters and facial paralysis. Other symptoms of Ramsay Hunt syndrome may include:
- ear pain,
- hearing loss,
- dizziness (or vertigo),
- dry eye,
- and changes in taste sensation.
- antiviral agents,
- steroids, and
- pain medications.
Sexually Transmitted Diseases (STDs In Women)
Sexually transmitted diseases, or STDs, are infections that are transmitted during any type of sexual exposure, including intercourse (vaginal or anal), oral sex, and the sharing of sexual devices, such as vibrators. Women can contract all of the STDs, but may have no symptoms, or have different symptoms than men do. Common STDs in women are:
- Zika virus
- Genital herpes
- Hepatitis B
- Hepatitis C
- Pubic lice
- Genital warts
Treatment for STDs depends upon the type.
Sexually Transmitted Diseases and Pregnancy (STDs)When you are pregnant, many sexually transmitted diseases (STDs) can be especially harmful to you and your baby. These STDs include herpes, HIV/AIDS, genital warts (HPV), hepatitis B, chlamydia, syphilis, gonorrhea, and trichomoniasis. Symptoms include bumps, sores, warts, swelling, itching, or redness in the genital region. Treatment of STDs while pregnant depends on how far along you are in the pregnancy and the progression of the infection.
Shingles (Herpes Zoster)Shingles, or herpes zoster, is a painful rash caused by the varicella zoster virus. Other shingles symptoms include headache, fever, nausea, and body aches. Treatment focuses on pain management and shortening the duration of the illness with antiviral medications.
Take the Shingles QuizShingles falls within a well-known family of viruses that cause itching, burning, blisters, and pain. Take the Shingles Quiz to get the facts, causes, symptoms, and treatments for this itchy, painful condition.
Shingles PicturesAn acute infection caused by the herpes zoster virus, the same virus as causes chickenpox. See a picture of Shingles and learn more about the health topic.
STDs in Men Overview
Sexually transmitted diseases (STDs) are infections transmitted during sexual contact. They may be caused by viruses, bacteria, or parasites. STDs in men cause no symptoms or symptoms like
genital burning, itching, sores, rashes, or discharge.
Common infections that are sexually transmitted in men include gonorrhea, chlamydia, syphilis, hepatitis C and B, genital warts, human papillomavirus (HPV), and genital herpes.
Some STDs in men are treatable while others are not. STDs are diagnosed with tests that identify proteins or genetic material of the organisms causing the infection. The prognosis of an STD depends on whether the infection is treatable or not. Use of latex condoms can help reduce the risk of contracting an STD but it does not eliminate the risk entirely.
Tongue ProblemsThere are a variety of diseases and conditions that can cause tongue problems, discoloration, and soreness. Though most tongue problems are not serious. Conditions such as leukoplakia, oral thrush, and oral lichen planus may cause a white tongue while Kawasaki syndrome, scarlet fever, and geographic tongue may cause the tongue to appear red. A black hairy tongue may be caused by overgrown papillae on the tongue. Canker sores, smoking, and trauma may cause soreness of the tongue.