Sectral (acebutolol)

  • Pharmacy Author:
    Annette (Gbemudu) Ogbru, PharmD, MBA

    Dr. Gbemudu received her B.S. in Biochemistry from Nova Southeastern University, her PharmD degree from University of Maryland, and MBA degree from University of Baltimore. She completed a one year post-doctoral fellowship with Rutgers University and Bristol Myers Squibb.

  • Pharmacy Author: Omudhome Ogbru, PharmD
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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What brand names are available for acebutolol?

Sectral

Is acebutolol available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for acebutolol?

Yes

What are the uses for acebutolol?

What are the side effects of acebutolol?

Most adverse reactions to Sectral have been mild, not required discontinuation of therapy, and tended to decrease as the duration of treatment increases. Adverse events include:

Possible serious side effects include:

With serious adverse events such as shortness of breath or wheezing, swelling of the feet and lower legs and chest pain, it is advisable to contact a doctor immediately.

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What is the dosage for acebutolol?

  • Sectral can be taken with or without food, usually once or twice daily.
  • The dosage of Sectral should be reduced in patients with dysfunction of the kidneys or liver since kidney or liver disease reduce the elimination of Sectral.

Which drugs or supplements interact with acebutolol?

  • The use of beta blockers together with fenoldopam (Corlopam), a drug used to manage severe high blood pressure, may result in unexpectedly low blood pressure since beta-adrenergic blocking drugs add to the blood pressure-lowering effects of fenoldopam.
  • With concomitant use of clonidine (Catapres) and beta-adrenergic blocking drugs, severe high blood pressure may occur if patients abruptly discontinue the clonidine. Because of this effect, it is advisable to discontinue beta-adrenergic blocking drugs prior to starting clonidine.
  • Using epinephrine (Adrenalin, EpiPen) and beta-adrenergic blocking drugs together causes high blood pressure and a slow heartbeat since the beta-adrenergic stimulating effects of epinephrine that raise blood pressure and heart rate are exaggerated by the beta-adrenergic blocking drugs which prevent dilation of the blood vessels and increase the heart rate. To avoid this effect, it is best not to use both drugs together. If, however, both drugs are administered together, it is important to monitor blood pressure levels. Also, high blood pressure and a slow heartbeat are less likely to occur if beta-adrenergic blocking drugs that are selective for the heart such as atenolol (Tenormin) and Sectral (Sectral) are used.
  • Epinephrine- and norepinephrine-depleting drugs, such as reserpine (Harmonyl), may have an additive effect when given with beta-blocking drugs and cause an abnormally slow heart beat or low blood pressure, which may give rise to dizziness or fainting.

Is acebutolol safe to take if I'm pregnant or breastfeeding?

  • There are no adequate studies of Sectral in pregnant women. It should be used during pregnancy only if the potential benefit justifies the risk to the fetus
  • Sectral is excreted in human milk, and use among nursing mothers is discouraged.

What else should I know about acebutolol?

What preparations of acebutolol are available?

Capsules: 200 and 400 mg.

How should I keep acebutolol stored?

Capsules should be stored at room temperature, 77 F (25 C), away from light and moisture.

Reference: FDA Prescribing Information

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Summary

Sectral (acebutolol, Prent- has been discontinued) is a prescription drug used to treat high blood pressure and heart arrhythmias. It also is used to treat chest pain due to angina. Side effects include

Drug interactions, dosage, and pregnancy and breastfeeding safety information should be reviewed prior to taking any medication.

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Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

See more info: acebutolol on RxList
Reviewed on 9/23/2016
References
Reference: FDA Prescribing Information

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