- Abilify vs. Invega
- What Are They?
- Side Effects
- Drug Interactions
- Warnings and Precautions
Abilify vs. Invega
- Abilify (aripiprazole) and Invega (paliperidone) are antipsychotic drugs used to treat schizophrenia.
- A difference is that Abilify is also used to treat mania, depression, bipolar disorders, autistic disorders, and some irritable behavior disorders.
- Common side effects of Abilify and Invega include:
- Serious side effects of Abilify and Invega include:
- Both Abilify and Invega may interact with other medicines that make you sleepy (such as cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety), medications to treat high blood pressure or a heart condition, carbamazepine.
- Abilify may also interact with:
- Invega may also interact with:
What is Abilify? What is Invega?
- Abilify (aripiprazole) is a psychotropic drug (antipsychotic) that alters brain chemical activity used to treat
- Invega (paliperidone) is an antipsychotic medication used to treat
Abilify and Invega warnings, side effects, and patient safety information
Long-term use of aripiprazole may lead to a potentially irreversible condition called tardive dyskinesia (involuntary movements of the jaw, lips, and tongue).
- High fevers
- Muscle rigidity
- Altered mental status
- Irregular pulse or blood pressure
- Rapid heart rate
- Excessive sweating
- Heart arrhythmias
All atypical antipsychotic drugs have been associated with metabolic changes such as hyperglycemia, diabetes mellitus, dyslipidemia, and weight gain. Serious cases of hyperglycemia leading to coma or death have been reported in patients treated with atypical antipsychotics. Although there is no clear link between aripiprazole and diabetes, patients should be tested during treatment for elevated blood-sugars. Additionally, patients with risk factors for diabetes, including obesity or a family history of diabetes, should have their fasting levels of blood sugar tested before starting treatment and periodically throughout treatment to detect the onset of diabetes. Any patient developing symptoms that suggest diabetes during medical treatment should be tested for diabetes.
Elderly patients with dementia-related psychosis treated with antipsychotics are at an increased risk of death and Abilify should not be used for this indication. Antidepressants increased the risk of suicidal thinking and behavior in short-term studies in children and adolescents with depression and other psychiatric disorders. Anyone considering the use of this medicine or any other antidepressant in a child or adolescent must balance this risk of suicide with the clinical need. Patients who are started on medical therapy should be closely observed for clinical worsening, suicidal thoughts, or unusual changes in behavior.
Some of the most common side effects include:
- Blurred vision
- Runny nose
- Weight gain
The most common side effects include
- weight gain,
- upper respiratory tract infection,
- increased heart rate,
- feeling restlessness or difficulty sitting still,
- stiffness, and shuffling walk,
- tremors, and
- slow movements.
Less common but serious side effects include:
- Increased risk of stroke and death in elderly patients with dementia-related psychosis.
- Neuroleptic malignant syndrome (NMS): NMS is a rare but serious side effects associated with the use of antipsychotics. NMS may result in death and must be treated in the hospital. Signs and symptoms of NMS may include
- high fever,
- sweating (diaphoresis),
- severe muscle stiffness or rigidity,
- loss of consciousness,
- high blood pressure,
- rapid heartbeat, and
- changes in breathing.
- Extrapyramidal side effects (EPS) including:
- Pseudoparkinsonism: drug induced Parkinson's symptoms.
- Tardive dyskinesia (TD): Tardive dyskinesia usually occurs after long-term use of antipsychotics and usually presents with movement problems affecting the tongue, lips, jaw, face, and extremities.
- Metabolic changes including high blood sugar (hyperglycemia), diabetes mellitus, increase in blood cholesterol, and weight gain.
- High blood levels of prolactin. Prolactin is a hormone that allows the production of breast milk. High levels of prolactin may cause menstrual abnormalities, leakage of milk from the breast, development of breast in males (gynecomastia), and erection problems in men.
What are the drugs that interact with Abilify and Invega?
- Carbamazepine (Tegretol) can markedly decrease the amount of Abilify in the body by increasing the rate at which the body's enzymes (particularly the liver enzyme, CYP3A4) degrade it. The manufacturer recommends that patients on this drug who are started on carbamazepine double their dose of Abilify, under their doctor's supervision. Other drugs that can promote the activity of CYP3A4 and decrease the body's levels of Abilify are phenytoin (Dilantin), rifampin (Rifadin, Rimactane, Rifadin, Rifater, Rifamate), and phenobarbital.
- Ketoconazole (Nizoral) can increase the amount of aripiprazole in the body by blocking CYP3A4. The manufacturer of aripiprazole recommends reducing the dose of aripiprazole by one-half during ketoconazole therapy. Many other drugs also are known to block CYP3A4 and potentially could increase the levels of aripiprazole, but their actual effects on aripiprazole levels have not been studied. Such drugs include:
- itraconazole (Sporanox)
- fluconazole (Diflucan)
- voriconazole (Vfend)
- cimetidine (Tagamet)
- verapamil (Calan, Isoptin)
- diltiazem (Cardizem, Dilacor)
- erythromycin clarithromycin (Biaxin)
- nefazodone (Serzone)
- ritonavir (Norvir)
- saquinavir (Invirase)
- nelfinavir (Viracept)
- indinavir (Crixivan)
- Grapefruit juice
- Quinidine (Quinaglute, Quinidex) inhibits another liver enzyme known as CYP2D6 that also breaks down aripiprazole and can increase the amount of aripiprazole in the body. The manufacturer of aripiprazole recommends reducing the dose of aripiprazole by one-half during quinidine therapy. Other medicines that block CYP2D6 include fluoxetine (Prozac) and paroxetine (Paxil).
- Alpha-1 receptor blockers [doxazosin (Cardura), prazosin (Minipress), terazosin (Hytrin)], used for control of blood pressure and prostatic enlargement, may increase the chance of hypotension (unusually low blood pressure).
- Paliperidone can cause low blood pressure especially when standing up from a sitting or lying position (orthostatic hypotension). Therefore, paliperidone should be used cautiously with other drugs also associated with orthostatic hypotension.
- Paliperidone is metabolized (eliminated) by liver enzymes. Drugs that increase the activity of these enzymes will decrease blood levels of paliperidone thereby decreasing its effect. Paliperidone should not be taken with carbamazepine (Tegretol), phenytoin (Dilantin), rifampin (Rifadin), St. John's Wort, and other drugs that may decrease its blood levels.
- Paliperidone blocks the effect of dopamine in the brain while dopamine agonists such as levodopa (Sinemet) increase the levels of dopamine in the brain. Combining these agents is not recommended since the effect of both drugs will be reduced.
- Divalproex sodium increases blood levels of paliperidone by 50%. The dose of paliperidone should be adjusted based on clinical judgment.
What is the dosage for Abilify vs. Invega?
- This dose for this medication usually is once a day.
- The usual adult starting oral dose for patients with schizophrenia or bipolar disorder is 10 to 15 mg once daily. The dose may be increased over time up to 30 mg daily to achieve the desired effect.
- The recommended dose for patients with Tourette's disorder is 5 to 20 mg once daily.
- Paliperidone is administered once daily by mouth.
- Tablets should be swallowed whole and should not be crushed, divided, or chewed.
- The starting dose for schizophrenia or schizoaffective disorder in adults is 6 mg daily.
- The maintenance dose range is 3 to 12 mg daily.
- The maximum dose is 12 mg daily.
- The dose for treating schizophrenia in adolescents weighing less than 51 kg is 3 to 6 mg daily.
- The dose for adolescents weighing more than 51 kg is 3 to 12 mg daily.
Latest Medications News
Daily Health News
Are Abilify and Invega Safe to Take During Pregnancy?
Aripiprazole has not been adequately studied during pregnancy. Neonates exposed to antipsychotic drugs in the third trimester may experience withdrawal symptoms and other side effects. Your doctor or other healthcare provider may choose to use this medication if he or she feels that its benefits outweigh this potential concern.
It is not known if this medicine is excreted in breast milk; however, since most medicines are excreted in breast milk, doctors and other health care professionals recommend that women should not breastfeed their infant/baby while taking this drug.
Unborn babies exposed to antipsychotics during the third trimester of pregnancy are at risk for extrapyramidal and withdrawal symptoms after birth. Symptoms reported included agitation, hypertonia, hypotonia, tremor, somnolence, depressed breathing, and feeding disorder. Currently there is no data on the use of paliperidone during pregnancy.
Paliperidone should only be used during pregnancy if the potential benefit to the mother outweighs the potential for side effects in the fetus.
A pregnancy exposure registry has been established to monitor the use of atypical antipsychotics, including paliperidone, during pregnancy.
All pregnant women treated with atypical antipsychotics are advised to enroll in this pregnancy registry and report any side effects.
Abilify (aripiprazole) and Invega (paliperidone) are antipsychotic drugs used to treat schizophrenia. Abilify is also used to treat mania, bipolar disorders, autistic disorders, and some irritable behavior disorders. Side effects of both drugs include:pregnancy safety information for Abilify vs. Invega.
Multimedia: Slideshows, Images & Quizzes
Schizophrenia: Symptoms, Types, Causes, Treatment
What is schizophrenia? Learn about schizophrenia symptoms, signs, and treatment. Read about schizophrenia types such as paranoid...
Schizophrenia Quiz: What is Schizophrenia?
Schizophrenia is a complex psychiatric disorder. Learn more about the challenges of mental illness with the Schizophrenia Quiz.
Related Disease Conditions
Schizophrenia is a disabling brain disorder that may cause hallucinations and delusions and affect a person's ability to communicate and pay attention. Symptoms of psychosis appear in men in their late teens and early 20s and in women in their mid-20s to early 30s. With treatment involving the use of antipsychotic medications and psychosocial treatment, schizophrenia patients can lead rewarding and meaningful lives.
Schizophrenia and Electroconvulsive Therapy (ECT)
Second Source article from WebMD
Second Source article from Government
Bipolar disorder (or manic depression) is a mental illness characterized by depression, mania, and severe mood swings. Treatment may incorporate mood-stabilizer medications, antidepressants, and psychotherapy.
Bipolar Disorder vs. Schizophrenia
Bipolar disorder and schizophrenia are mental illnesses that share some risk factors and treatments. Symptoms of bipolar disorder include mood changes and manic and depressive episodes. Symptoms of schizophrenia include unusual behavior, delusions, and hallucinations.
Bipolar Disorder in Children and Teens
Bipolar disorder, or manic-depressive illness, is a disorder that causes unusual and extreme mood changes. Symptoms of bipolar disorder in children and teens include having trouble concentrating, behaving in risky ways, and losing interest in activities they once enjoyed. Treatment for bipolar disorder in children and teenagers incorporates psychotherapy and medications.
Treatment & Diagnosis
Medications & Supplements
- aripiprazole (Abilify, Aristrada)
- Haldol (haloperidol) vs. Abilify (aripiprazole)
- paliperidone (Invega)
- Side Effects of Invega Sustenna (paliperidone palmitate)
- paliperidone palmitate (Invega Sustenna)
- paliperidone palmitate (Invega Trinza)
- Side Effects of Invega (paliperidone)
- Side Effects of Invega Trinza (paliperidone palmitate)
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.