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- What is abacavir, lamivudine, zidovudine, and how does it work (mechanism of action)?
- What are the side effects of abacavir, lamivudine, zidovudine?
- What is the dosage for abacavir, lamivudine, zidovudine?
- Is abacavir, lamivudine, zidovudine safe to take if I'm pregnant or breastfeeding?
- What else should I know about abacavir, lamivudine, zidovudine?
What is abacavir, lamivudine, zidovudine, and how does it work (mechanism of action)?
Trizivir is a combination oral medication that is used for treating infections with the human immunodeficiency virus (HIV). Trizivir contains abacavir (Ziagen), lamivudine (Epivir) and zidovudine (Retrovir), which are three different anti-HIV drugs with different mechanisms of action. Anti-HIV drugs are often used in combination to increase HIV suppression and to reduce the chance of the HIV developing resistance to any single drug. Combining these three drugs into one pill reduces the number of individual medications that a patient has to take, which makes it easier for patients to comply with therapy. Administration of one tablet of Trizivir is equal to giving 300 mg of abacavir, 150 mg of lamivudine and 300 mg of zidovudine together. Trizivir does not reduce the transmission of HIV among individuals, and it does not cure HIV or AIDS. Trizivir was approved by the FDA in November 2000.
What brand names are available for abacavir, lamivudine, zidovudine?
Is abacavir, lamivudine, zidovudine available as a generic drug?
Do I need a prescription for abacavir, lamivudine, zidovudine?
What are the side effects of abacavir, lamivudine, zidovudine?
Trizivir causes the same side effect as its component drugs, abacavir, lamivudine and zidovudine. The most common side effects are:
Serious and sometimes fatal hypersensitivity reactions involving several organs have been associated with abacavir, a component of Trizivir. Symptoms include fever, rash, nausea, vomiting, diarrhea, abdominal pain, fatigue, aches, shortness of breath, cough, and sore throat. Patients should discontinue Trizivir if a hypersensitivity reaction is suspected. Patients who carry a certain genetic marker called HLA-B 5701 are at high risk for experiencing a hypersensitivity reaction to abacavir. Screening for the HLA-B 5701 allele is recommended prior to initiating therapy with abacavir.
Other important side effects of the abacavir component include:
What is the dosage for abacavir, lamivudine, zidovudine?
The recommended dose for adults and adolescents is one tablet twice daily.
Is abacavir, lamivudine, zidovudine safe to take if I'm pregnant or breastfeeding?
Use of Trizivir by nursing women has not been adequately studied. Nevertheless, HIV-infected mothers should not breastfeed because of the potential risk of transmitting HIV to an infant that is not infected.
What else should I know about abacavir, lamivudine, zidovudine?
What preparations of abacavir, lamivudine, zidovudine are available?
Tablets: 300 mg abacavir/150 mg lamivudine/300 mg zidovudine.
How should I keep abacavir, lamivudine, zidovudine stored?
Capsules and powder should be stored at room temperature, 15 C to 30 C (59 F to 86 F).
Abacavir, lamivudine, zidovudine (Trizivir) is a combination drug prescribed to treat human immunodeficiency virus (HIV) infections. Side effects, drug interactions, dosage, and pregnancy information should be reviewed prior to taking this medication.
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Related Disease Conditions
AIDS (Acquired Immunodeficiency Syndrome)
AIDS is the advanced stage of HIV infection. Symptoms and signs of AIDS include pneumonia due to Pneumocystis jiroveci, tuberculosis, toxoplasmosis, seizures, weakness, meningitis, yeast infection of the esophagus, and Kaposi's sarcoma. Anti-retroviral therapy (HAART) is used in the treatment of AIDS.
Human Immunodeficiency Virus (HIV)
HIV (human immunodeficiency virus) infection left untreated causes AIDS (acquired immunodeficiency syndrome). Still incurable, AIDS describes immune system collapse that opens the way for opportunistic infections and cancers to kill the patient. Early symptoms and signs of HIV infection include flu-like symptoms and fungal infections, but some people may not show any symptoms for years. Highly active antiretroviral therapy (ART) is the standard treatment for HIV infection. These combination drug regimens have made HIV much less deadly, but a cure or vaccine for the pandemic remains out of reach. HIV is usually transmitted through sexual contact or sharing IV drug needles, but can also infect someone through contact with infected blood. Sexual abstinence, safe sex practices, quitting IV drugs (or at least using clean needles), and proper safety equipment by clinicians and first responders can drastically reduce transmission rates for HIV/AIDS.
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