- What is abacavir, lamivudine, zidovudine, and how does it work (mechanism of action)?
- What are the side effects of abacavir, lamivudine, zidovudine?
- What is the dosage for abacavir, lamivudine, zidovudine?
- Is abacavir, lamivudine, zidovudine safe to take if I'm pregnant or breastfeeding?
- What else should I know about abacavir, lamivudine, zidovudine?
What is abacavir, lamivudine, zidovudine, and how does it work (mechanism of action)?
Trizivir is a combination oral medication that is used for treating infections with the human immunodeficiency virus (HIV). Trizivir contains abacavir (Ziagen), lamivudine (Epivir) and zidovudine (Retrovir), which are three different anti-HIV drugs with different mechanisms of action. Anti-HIV drugs are often used in combination to increase HIV suppression and to reduce the chance of the HIV developing resistance to any single drug. Combining these three drugs into one pill reduces the number of individual medications that a patient has to take, which makes it easier for patients to comply with therapy. Administration of one tablet of Trizivir is equal to giving 300 mg of abacavir, 150 mg of lamivudine and 300 mg of zidovudine together. Trizivir does not reduce the transmission of HIV among individuals, and it does not cure HIV or AIDS. Trizivir was approved by the FDA in November 2000.
What brand names are available for abacavir, lamivudine, zidovudine?
Is abacavir, lamivudine, zidovudine available as a generic drug?
Do I need a prescription for abacavir, lamivudine, zidovudine?
What are the side effects of abacavir, lamivudine, zidovudine?
Trizivir causes the same side effect as its component drugs, abacavir, lamivudine and zidovudine. The most common side effects are:
Serious and sometimes fatal hypersensitivity reactions involving several organs have been associated with abacavir, a component of Trizivir. Symptoms include fever, rash, nausea, vomiting, diarrhea, abdominal pain, fatigue, aches, shortness of breath, cough, and sore throat. Patients should discontinue Trizivir if a hypersensitivity reaction is suspected. Patients who carry a certain genetic marker called HLA-B 5701 are at high risk for experiencing a hypersensitivity reaction to abacavir. Screening for the HLA-B 5701 allele is recommended prior to initiating therapy with abacavir.
Other important side effects of the abacavir component include:
What is the dosage for abacavir, lamivudine, zidovudine?
The recommended dose for adults and adolescents is one tablet twice daily.
Is abacavir, lamivudine, zidovudine safe to take if I'm pregnant or breastfeeding?
Use of Trizivir by nursing women has not been adequately studied. Nevertheless, HIV-infected mothers should not breastfeed because of the potential risk of transmitting HIV to an infant that is not infected.
What else should I know about abacavir, lamivudine, zidovudine?
What preparations of abacavir, lamivudine, zidovudine are available?
Tablets: 300 mg abacavir/150 mg lamivudine/300 mg zidovudine.
How should I keep abacavir, lamivudine, zidovudine stored?
Capsules and powder should be stored at room temperature, 15 C to 30 C (59 F to 86 F).
Abacavir, lamivudine, zidovudine (Trizivir) is a combination drug prescribed to treat human immunodeficiency virus (HIV) infections. Side effects, drug interactions, dosage, and pregnancy information should be reviewed prior to taking this medication.
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Related Disease Conditions
Human Immunodeficiency Virus (HIV)
HIV (human immunodeficiency virus) infection left untreated causes AIDS (acquired immunodeficiency syndrome). The human immunodeficiency virus (HIV) is a type of virus called a retrovirus, which can infect humans when it comes in contact with tissues that line the vagina, anal area, mouth, or eyes, or through a break in the skin. HIV infection is generally a slowly progressive disease in which the virus is present throughout the body at all stages of the disease. Three stages of HIV infection have been described. The initial stage of infection (primary infection), which occurs within weeks of acquiring the virus, often is characterized by the flu- or mono-like illness that generally resolves within weeks. The stage of chronic asymptomatic infection (meaning a long duration of infection without symptoms) lasts an average of eight to 10 years without treatment. The stage of symptomatic infection, in which the body's immune (or defense) system has been suppressed and complications have developed, is called the acquired immunodeficiency syndrome (AIDS). The symptoms are caused by the complications of AIDS, which include one or more unusual infections or cancers, severe loss of weight, and intellectual deterioration (called dementia). When HIV grows (that is, by reproducing itself), it acquires the ability to change (mutate) its own structure. These mutations enable the virus to become resistant to previously effective drug therapy. The goals of drug therapy are to prevent damage to the immune system by the HIV virus and to halt or delay the progress of the infection to symptomatic disease. Therapy for HIV includes combinations of drugs that decrease the growth of the virus to such an extent that the treatment prevents or markedly delays the development of viral resistance to the drugs. The best combination of drugs for HIV are those that effectively suppress viral replication in the blood and also are well tolerated and simple to take so that people can take the medications consistently without missing doses.
AIDS (Acquired Immunodeficiency Syndrome)
AIDS is the advanced stage of HIV infection. Symptoms and signs of AIDS include pneumonia due to Pneumocystis jiroveci, tuberculosis, toxoplasmosis, seizures, weakness, meningitis, yeast infection of the esophagus, and Kaposi's sarcoma. Anti-retroviral therapy (HAART) is used in the treatment of AIDS.
Treatment & Diagnosis
- HIV-AIDS FAQs
- Prescriptions: Complying with the Doctor's Orders
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Drugs: The Most Common Medication Errors
- Medication Disposal
- Dangers of Mixing Medications
- Drugs: Buying Prescription Drugs Online Safely
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
- Drugs: Questions to Ask Your Doctor or Pharmacist about Your Drugs
- Drug Interactions
- abacavir, Ziagen
- Retrovir (zidovudine, ZDV, formerly called AZT)
- lamivudine (3tc) (Epivir; Epivir HBV)
- What Are NRTIs in Antiretroviral Therapy For HIV Infection?
- Dovato (dolutegravir and lamivudine)
- didanosine (Videx, Videx EC)
- Temixys (lamivudine and tenofovir disoproxil fumarate)
- Combivir (lamivudine and zidovudine)
- Triumeq (abacavir, dolutegravir, and lamivudine)
- Side Effects of Trizivir (abacavir, lamivudine, zidovudine)
- Epzicom (abacavir sulfate and lamivudine)
- stavudine (Zerit)
Prevention & Wellness
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.