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- What is abacavir, lamivudine, zidovudine, and how does it work (mechanism of action)?
- What brand names are available for abacavir, lamivudine, zidovudine?
- Is abacavir, lamivudine, zidovudine available as a generic drug?
- Do I need a prescription for abacavir, lamivudine, zidovudine?
- What are the side effects of abacavir, lamivudine, zidovudine?
- What is the dosage for abacavir, lamivudine, zidovudine?
- Is abacavir, lamivudine, zidovudine safe to take if I'm pregnant or breastfeeding?
- What else should I know about abacavir, lamivudine, zidovudine?
What is abacavir, lamivudine, zidovudine, and how does it work (mechanism of action)?
Trizivir is a combination oral medication that is used for treating infections with the human immunodeficiency virus (HIV). Trizivir contains abacavir (Ziagen), lamivudine (Epivir) and zidovudine (Retrovir), which are three different anti-HIV drugs with different mechanisms of action. Anti-HIV drugs are often used in combination to increase HIV suppression and to reduce the chance of the HIV developing resistance to any single drug. Combining these three drugs into one pill reduces the number of individual medications that a patient has to take, which makes it easier for patients to comply with therapy. Administration of one tablet of Trizivir is equal to giving 300 mg of abacavir, 150 mg of lamivudine and 300 mg of zidovudine together. Trizivir does not reduce the transmission of HIV among individuals, and it does not cure HIV or AIDS. Trizivir was approved by the FDA in November 2000.
What are the side effects of abacavir, lamivudine, zidovudine?
Trizivir causes the same side effect as its component drugs, abacavir, lamivudine and zidovudine. The most common side effects are:
Serious and sometimes fatal hypersensitivity reactions involving several organs have been associated with abacavir, a component of Trizivir. Symptoms include fever, rash, nausea, vomiting, diarrhea, abdominal pain, fatigue, aches, shortness of breath, cough, and sore throat. Patients should discontinue Trizivir if a hypersensitivity reaction is suspected. Patients who carry a certain genetic marker called HLA-B 5701 are at high risk for experiencing a hypersensitivity reaction to abacavir. Screening for the HLA-B 5701 allele is recommended prior to initiating therapy with abacavir.
Other important side effects of the abacavir component include:
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Is abacavir, lamivudine, zidovudine safe to take if I'm pregnant or breastfeeding?
Use of Trizivir by nursing women has not been adequately studied. Nevertheless, HIV-infected mothers should not breastfeed because of the potential risk of transmitting HIV to an infant that is not infected.
What else should I know about abacavir, lamivudine, zidovudine?
What preparations of abacavir, lamivudine, zidovudine are available?
Tablets: 300 mg abacavir/150 mg lamivudine/300 mg zidovudine.
How should I keep abacavir, lamivudine, zidovudine stored?
Capsules and powder should be stored at room temperature, 15 C to 30 C (59 F to 86 F).
Reference: FDA Prescribing Information
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Top abacavir, lamivudine, zidovudine Related ArticlesComplete List
abacavirAbacavir (Ziagen) is a drug prescribed when in used in combination of other anti-HIV drugs to treat HIV infection. Side effects, Drug interactions, and dosage information should be reviewed prior to taking this medication.
Acquired Immunodeficiency Syndrome (AIDS)AIDS is the advanced stage of HIV infection. Symptoms and signs of AIDS include pneumonia due to Pneumocystis jiroveci, tuberculosis, toxoplasmosis, seizures, weakness, meningitis, yeast infection of the esophagus, and Kaposi's sarcoma. Anti-retroviral therapy (HAART) is used in the treatment of AIDS.
didanosineDidanosine (Videx, Videx EC) is a drug prescribed for the treatment of the human immunodeficiency virus (HIV) in adults and children. Side effects, drug interactions, pregnancy safety, and warnings and precautions should be reviewed prior to taking this medication.
Drug InteractionsDrug interactions occur frequently. Get facts about the types of drug interactions, what substances or other things that may interact with drugs such as OTC drug and prescription drugs, vitamins, food(s) (grapefruit), and laboratory tests. Find out how to protect yourself from potential drug interactions.
Drugs: What You Should Know About Your DrugsImportant information about your drugs should be reviewed prior to taking any prescription drug. Side effects, drug interactions, warnings and precauctions, dosage, what the drug is used for, what to do if you miss a dose, how the drug is to be stored, and generic vs. brand names.
HIV TestingHIV antibody tests detect antibodies the body produces to neutralize the virus. HIV RNA testing uses polymerase chain reaction to detect HIV RNA in a person's blood. It usually takes one to three days to get results.
HIV/AIDS QuizNow, more than ever, you should know about HIV/AIDS, especially its causes, symptoms treatments, and complications. Take the HIV/AIDS Quiz now!
HIV/AIDS PictureAcronym for the Human Immunodeficiency Virus, the cause of AIDS (acquired immunodeficiency syndrome). See a picture of HIV/AIDS and learn more about the health topic.
Human Immunodeficiency Virus (HIV)The human immunodeficiency virus (HIV) causes HIV infection and the acquired immunodeficiency syndrome (AIDS). Symptoms and signs of HIV infection include fatigue, enlarged lymph glands, and recurrent vaginal yeast infections. Highly active antiretroviral therapy (ART) is the standard treatment for HIV infection.
Lamivudine (3tc) (Epivir; Epivir HBV) is a drug prescribed for the treatment of HIV infection and hepatitis B infection. The most serious side include
- muscle pain,
- liver failure,
- pancreatitis, and
- liver failure.
Drug interactions, and dosage, and pregnancy and breastfeeding safety information should be reviewed prior to taking this medication.
lamivudine and zidovudine
Combivir (lamivudine and zidovudine) is a drug that is used in combination with other agents to treat HIV infection. Serious side effects include:
- Fatty liver
- Liver enlargement
- Lactic acidosis.
Drug interactions, and dosage, and pregnancy and breastfeeding information should be reviewed prior to taking this medication.
stavudineStavudine (Zerit) is a medication prescribed for the treatment of HIV infection. Zerit is prescribed to be used in combination with other anti-HIV infection drugs. Side effects, drug interactions, dosage, and pregnancy safety should be reviewed prior to taking this medication.
Retrovir (zidovudine, ZDV, formerly called AZT) is a medication (oral and injectable) prescribed for the treatment of infections with HIV (human immunodeficiency virus). Side effects include:
- Weight loss
Drug interactions, dosage, and pregnancy and breastfeeding safety information, and dosing should be reviewed before taking any medication.