zonisamide (Zonegran) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Serious side effects of zonisamide include:

  • Psychiatric disorders such as schizophrenia
  • Seizures
  • Serious skin disorders such as Stevens-Johnson's syndrome or toxic epidermal necrolysis.



PREPARATIONS: Capsules: 25, 50, and 100 mg.

STORAGE: Store zonisamide capsules between 20 C and 25 C (68 F and 77 F).

DOSING: The recommended starting dose of zonisamide is 100 mg/day. Doses may be increased 100 mg/day every 2 weeks. The usual dosage varies from 100 to 600 mg/day, administered in 1 to 2 divided doses.

Safe and effective use of zonisamide is not established for children under the age of 16.

DRUG INTERACTIONS: Zonisamide increases the risk of lactic acid build up when combined with metformin (Glucophage). If you experience sudden weakness, heavy breathing, and increased drowsiness, contact your healthcare professional immediately.

Orlistat (Xenical) should be used with caution with zonisamide because it lowers the beneficial effects of zonisamide and increases the chances of seizures. If you experience dizziness, drowsiness, difficulty walking, nausea, vomiting, and abnormal eye movements, contact your healthcare professional immediately.

PREGNANCY: There are no adequate studies done on zonisamide to determine its safe and effective use in pregnant mothers.

NURSING MOTHERS: It is not known whether zonisamide is excreted in breast milk. It should be used with caution in females who are nursing.

REFERENCE: FDA Prescribing Information.

Medically Reviewed by a Doctor on 12/22/2014

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