zonisamide (Zonegran)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

What is zonisamide-oral, and how does it work (mechanism of action)?

Zonisamide is an anti-seizure medication. Zonisamide is primarily used to treat partial-seizures. Scientists do not known how exactly zonisamide works in the body. Zonisamide is presumed to work on the sodium and calcium channels in the brain cells where it controls electric-currents that are responsible for seizure activity.

The FDA approved zonisamide in March 2000.

What brand names are available for zonisamide-oral?


Is zonisamide-oral available as a generic drug?


Do I need a prescription for zonisamide-oral?


What are the side effects of zonisamide-oral?

Common side effects of zonisamide are:

Serious side effects of zonisamide include:

  • Psychiatric disorders such as schizophrenia
  • Seizures
  • Serious skin disorders such as Stevens-Johnson's syndrome or toxic epidermal necrolysis.

Medically Reviewed by a Doctor on 5/16/2017

Quick GuideEpilepsy: Symptoms, Causes and Treatment

Epilepsy: Symptoms, Causes and Treatment
FDA Logo

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

RxList Logo

Need help identifying pills and medications?

Use the pill identifier tool on RxList.

Subscribe to MedicineNet's Newsletters

Get the latest health and medical information delivered direct to your inbox!

By clicking Submit, I agree to the MedicineNet's Terms & Conditions & Privacy Policy and understand that I may opt out of MedicineNet's subscriptions at any time.

Health Solutions From Our Sponsors