zolpidem, Ambien, Ambien CR, Zolpimist, Edluar, Tovalt ODT (discontinued) (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
Other side effects include:
Zolpidem can cause withdrawal symptoms (muscle cramps, sweats, shaking, and seizures) when the drug is abruptly discontinued. Zolpidem can cause abnormal behavior with confusion, paradoxical insomnia or "complex sleep-related behaviors," which may include sleep-driving (driving with no memory of having done so). If these side effects occur, zolpidem should be discontinued.
DOSING: The recommended adult dose of zolpidem is 10 mg as conventional tablets or spray or 12.5 mg as extended-release tablets. In elderly patients, an initial dose of 5 mg as conventional tablets or 6.25 mg as extended-release tablets is recommended because elderly patients have decreased ability to eliminate zolpidem from the body, and accumulating zolpidem may cause side effects.
DRUG INTERACTIONS: Alcohol has an additive effect with zolpidem and the two should not be combined. Zolpidem should not be combined with other sedative drugs because of the additive effects. Itraconazole (Sporanox) and ketoconazole (Nizoral, Extina, Xolegel, Kuric) may increase the blood concentration of zolpidem by reducing the activity of the enzymes that breakdown zolpidem in the liver. Conversely, rifampin may reduce the concentration of zolpidem by increasing the activity of of the enzymes that breakdown zolpidem.
GENERIC AVAILABLE: Yes
PREPARATION: Tablets: 5 and 10 mg. Tablet (extended release): 6.25 mg and 12.5 mg. Oral spray: 5 mg/spray
STORAGE: Zolpidem should be stored at room temperature, 20-25 C (68-77 F), in an air-tight container.
PREGNANCY: There are no adequate studies of zolpidem use in pregnant women.
NURSING MOTHERS: Zolpidem is excreted in human breast milk and may adversely affect the infant.
Medically reviewed by Eni Williams, PharmD
Medically Reviewed by a Doctor on 2/23/2015
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