zolpidem (Ambien, Ambien CR, Zolpimist, Edluar, [Tovalt ODT has been discontinued])

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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PREPARATIONS:

  • Tablets: 5 and 10 mg.
  • Tablet (extended release): 6.25 mg and 12.5 mg.
  • Oral spray: 5 mg/spray

DRUG INTERACTIONS:

  • Alcohol has an additive effect with zolpidem and the two should not be combined. Zolpidem should not be combined with other sedative drugs because of the additive effects.
  • Itraconazole (Sporanox) and ketoconazole (Nizoral, Extina, Xolegel, Kuric) may increase the blood concentration of zolpidem by reducing the activity of the enzymes that breakdown zolpidem in the liver. Conversely, rifampin may reduce the concentration of zolpidem by increasing the activity of the enzymes that breakdown zolpidem.

PREGNANCY AND BREASTFEEDING SAFETY:

STORAGE: Zolpidem should be stored at room temperature, 20-25 C (68-77 F), in an air-tight container.

DOSING:

  • The recommended adult dose of zolpidem conventional tablets or spray is 5 mg for females, the elderly, or fragile individuals, and 5 to 10 mg for males.
  • The maximum dose is 10 mg daily.
  • For females and the elderly, give 6.25 mg of extended-release tablets; and males should receive 6.25 to 12.5 mg.
  • The maximum dose of extended-release tablets is 12.5 mg daily.
  • Elderly patients have decreased ability to eliminate zolpidem from the body, and accumulating zolpidem may cause side effects.
Medically Reviewed by a Doctor on 6/16/2016
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