zolpidem (Ambien, Ambien CR, Zolpimist, Edluar, [Tovalt ODT has been discontinued])

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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What is zolpidem, and how does it work (mechanism of action)?

  • Zolpidem belongs to a class of drugs called sedatives or hypnotics. Zolpidem shares some characteristics of a family of sedatives called benzodiazepines. Benzodiazepines cause sedation, muscle relaxation, act as anti-convulsants (anti-seizure medications), and reduce anxiety. Zolpidem has selectivity in that it has little of the muscle relaxant and anti-seizure effects and more of the sedative effect. Therefore, it is used primarily as a medication for sleep. The oral spray form of zolpidem, Zolpimist, has more rapid absorption than the tablet form because it is absorbed through the lining of the mouth.

The FDA approved zolpidem in December 1992.

What brand names are available for zolpidem?

Ambien, Ambien CR, Intermezzo, Zolpimist, Edluar

Is zolpidem available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for zolpidem?

Yes

What are the uses for zolpidem?

  • Zolpidem is used for treating insomnia.
  • Conventional tablets are used for short-term treatment of insomnia associated with difficulty falling asleep.
  • Long acting tablets are used for treating insomnia associated with difficulty falling asleep or staying asleep.
  • Zolpidem improves initiation of sleep and keeps patients asleep longer.

What are the side effects of zolpidem?

The most common side effects of zolpidem are:

Other side effects include:

Zolpidem can cause withdrawal symptoms (muscle cramps, sweats, shaking, and seizures) when the drug is abruptly discontinued. Zolpidem can cause abnormal behavior with confusion, paradoxical insomnia or "complex sleep-related behaviors," which may include sleep-driving (driving with no memory of having done so). If these side effects occur, zolpidem should be discontinued.

What is the dosage for zolpidem?

  • The recommended adult dose of zolpidem conventional tablets or spray is 5 mg for females, the elderly, or fragile individuals, and 5 to 10 mg for males.
  • The maximum dose is 10 mg daily.
  • For females and the elderly, give 6.25 mg of extended-release tablets; and males should receive 6.25 to 12.5 mg.
  • The maximum dose of extended-release tablets is 12.5 mg daily.
  • Elderly patients have decreased ability to eliminate zolpidem from the body, and accumulating zolpidem may cause side effects.

Which drugs or supplements interact with zolpidem?

  • Alcohol has an additive effect with zolpidem and the two should not be combined. Zolpidem should not be combined with other sedative drugs because of the additive effects.
  • Itraconazole (Sporanox) and ketoconazole (Nizoral, Extina, Xolegel, Kuric) may increase the blood concentration of zolpidem by reducing the activity of the enzymes that breakdown zolpidem in the liver. Conversely, rifampin may reduce the concentration of zolpidem by increasing the activity of the enzymes that breakdown zolpidem.

Is zolpidem safe to take if I'm pregnant or breastfeeding?

What else should I know about zolpidem?

What preparations of zolpidem are available?

  • Tablets: 5 and 10 mg.
  • Tablet (extended release): 6.25 mg and 12.5 mg.
  • Oral spray: 5 mg/spray

How should I keep zolpidem stored?

Zolpidem should be stored at room temperature, 20-25 C (68-77 F), in an air-tight container.

REFERENCES:

FDA Prescribing Information for zolpidem

AHFS Drug Information for zolpidem

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See more info: zolpidem on RxList
Reviewed on 6/16/2016
References
REFERENCES:

FDA Prescribing Information for zolpidem

AHFS Drug Information for zolpidem

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