zolmitriptan, Zomig, Zomig-ZMT (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

DRUG INTERACTIONS: Monoamine oxidase inhibitors, for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine (Matulane)) may exaggerate the effects of zolmitriptan.

Zolmitriptan directly stimulates serotonin receptors on nerves. Serotonin reuptake inhibitors (SSRIs) that are used for treating depression, for example, fluoxetine (Prozac), paroxetine (Paxil), and sertraline (Zoloft), enhance the effects of serotonin by preventing its uptake by nerves. Therefore, the combination of zolmitriptan and an SSRI may lead to exaggerated effects of serotonin, and has been reported to cause weakness, increased reflexes, and loss of coordination.

Ergots, like dihydroergotamine (DHE) and ergotamine tartrate (Cafergot) that often are used to treat migraine headaches, can cause blood vessels to go into spasm. It is possible that the combination of ergots and zolmitriptan will result in exaggerated spasm of the vessels. Therefore, it is not recommended that zolmitriptan and ergots be used within 24 hours of each other.

Cimetidine (Tagamet) may double the concentration of zolmitriptan in the blood by interfering with its elimination. Potentially, this may lead to zolmitriptan toxicity.

PREGNANCY: Safe use in pregnancy has not been established.

NURSING MOTHERS: Safe use in nursing mothers has not been established.

SIDE EFFECTS: Side effects are generally transient. Some common side effects include pain or tightness in the chest or throat, tingling sensations, flushing, weakness, dizziness, abdominal discomfort, and sweating. Rarely, allergic reactions (even shock) have been reported though usually in individuals who are highly allergic to many substances.

Reference: FDA Prescribing Information


Last Editorial Review: 12/30/2010



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