zolmitriptan, Zomig, Zomig-ZMT (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
PRESCRIBED FOR: Zolmitriptan is used to relieve migraine headaches and associated nausea and sensitivity to light. It should not be used to treat types of headaches other than migraine.
SIDE EFFECTS: Side effects are generally transient. Some common side effects include:
GENERIC AVAILABLE: No
PREPARATIONS: Tablet: 2.5 and 5 mg. Tablet (orally disintegrating): 2.5 and 5 mg.
STORAGE: Zolmitriptan should be stored at room temperature, away from heat and light. It should be kept out of the reach of children.
DOSING: Dosing: The initial dose is 2.5 mg or less. The dose can be repeated after 2 hours if symptoms persist. The maximum dose is 10 mg per day. Doses less than 2.5 mg can be achieved by splitting the 2.5 mg tablet. Zolmitriptan may be taken with or without food.
DRUG INTERACTIONS: Monoamine oxidase inhibitors, for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine (Matulane)) may exaggerate the effects of zolmitriptan.
Zolmitriptan directly stimulates serotonin receptors on nerves. Serotonin reuptake inhibitors (SSRIs) that are used for treating depression, for example, fluoxetine (Prozac), paroxetine (Paxil), and sertraline (Zoloft), enhance the effects of serotonin by preventing its uptake by nerves. Therefore, the combination of zolmitriptan and an SSRI may lead to exaggerated effects of serotonin, and has been reported to cause weakness, increased reflexes, and loss of coordination.
Medically Reviewed by a Doctor on 5/18/2015
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