Bone is in a constant state of remodeling. New bone is laid down by cells called osteoblasts while old bone is removed by cells called osteoclasts. Bisphosphonates strengthen bone by inhibiting bone removal (resorption) by osteoclasts. After menopause, there is an increased rate of bone loss leading to osteoporosis. Bisphosphonates increase bone density and decrease bone fractures. The FDA approved Reclast in August 2007.
Medically reviewed by Eni Williams, PharmD
Reference: FDA Prescribing Information
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