zoledronic acid, Reclast (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

NURSING MOTHERS: It is not known whether zoledronic acid is excreted in human milk. Since many drugs are excreted in human milk, and zoledronic acid binds to bone long-term, zoledronic acid should not be administered to nursing women.

SIDE EFFECTS: The most common adverse reactions of zoledronic acid are fever, muscle pain, headache, and pain in hands and feet. Severe bone, joint, and muscle pain may occur. Low calcium levels may occur if calcium and vitamin D intake is not adequate. Reduced kidney function after administration of zoledronic acid has occurred. Patients may experience jaw problems (osteonecrosis of the jaw) associated with delayed healing and infection after tooth extraction. Bone, joint, and muscle pain also occur and low-trauma femoral fractures have been reported. Rare cases of severe allergic reactions involving shock, swelling of tongue, throat, and closure of airways have been reported.

Reference: FDA Prescribing Information

Last Editorial Review: 3/21/2012

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