zoledronic acid, Reclast (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Other important but rare side effects include cases of severe allergic reactions involving:

  • shock,
  • swelling of tongue,
  • throat, and
  • closure of airways

PREPARATIONS: Solution: 5 mg/100 ml

DRUG INTERACTIONS: Combining zoledronic acid with aminoglycoside antibiotics such as gentamycin or loop diuretics such as furosemide (Lasix) or bumetanide (Bumex) may lead to reduced calcium in blood. Zoledronic acid should be used with caution in patients who are taking drugs that affect kidney function because zoledronic acid has been associated with reduced kidney function. Since Reclast contains the same active ingredient as Zometa (zoledronic acid), patients treated with Zometa should not receive Reclast.

PREGNANCY AND BREASTFEEDING SAFETY: Zoledronic acid should not be administered to pregnant women. Women of childbearing age should be advised to use a reliable method of birth control.

It is not known whether zoledronic acid is excreted in human milk. Since many drugs are excreted in human milk, and zoledronic acid binds to bone long-term, zoledronic acid should not be administered to nursing women.


  • Unopened bottles should be kept at room temperature 15-30 C (59-86 F).
  • Opened bottles of solution are stable for 24 hours at 2-8 C (36-46 F).

DOSING: Zoledronic acid is given intravenously over no less than 15 minutes. Administration of acetaminophen or ibuprofen may reduce infusion related reactions.

  • For treatment of postmenopausal osteoporosis, a single 5 mg infusion once a year is recommended.
  • For prevention of postmenopausal osteoporosis the recommended dose is 5 mg every two years.
  • Paget's disease of bone is treated with a single 5 mg infusion. Patients with Paget's disease should also receive 1500 mg of elemental calcium and 800 IU vitamin D daily, especially during the two weeks after the injection of zoledronic acid.
  • For prevention or treatment of steroid-induced osteoporosis, the recommended dose is 5 mg once yearly.
Medically Reviewed by a Doctor on 1/5/2016

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