GENERIC NAME: zoledronic acid
BRAND NAME: Reclast
GENERIC AVAILABLE: No
USES: Zoledronic acid is used for treatment of osteoporosis in men and postmenopausal women as well as Paget's disease. It also is used to prevent osteoporosis in postmenopausal women and treatment of steroid-induced osteoporosis.
SIDE EFFECTS: The most common adverse reactions of zoledronic acid are:
Severe bone, joint, and muscle pain may occur. Low calcium levels may occur if calcium and vitamin D intake is not adequate. Reduced kidney function after administration of zoledronic acid has occurred. Patients may experience jaw problems (osteonecrosis of the jaw) associated with delayed healing and infection after tooth extraction. Bone, joint, and muscle pain also occur and low-trauma femoral fractures have been reported.
Other important but rare side effects include cases of severe allergic reactions involving:
- swelling of tongue,
- throat, and
- closure of airways
PREPARATIONS: Solution: 5 mg/100 ml
DRUG INTERACTIONS: Combining zoledronic acid with aminoglycoside antibiotics such as gentamycin or loop diuretics such as furosemide (Lasix) or bumetanide (Bumex) may lead to reduced calcium in blood. Zoledronic acid should be used with caution in patients who are taking drugs that affect kidney function because zoledronic acid has been associated with reduced kidney function. Since Reclast contains the same active ingredient as Zometa (zoledronic acid), patients treated with Zometa should not receive Reclast.
Quick GuideWhat Is Osteoporosis? Treatment, Symptoms, Medication in Pictures
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