zidovudine (Retrovir) (cont.)
GENERIC AVAILABLE: Yes
PREPARATIONS: Capsules: 100 mg; syrup 50 mg/5 ml; injections 10mg/ml
STORAGE: Store at room temperature, 15-30 C (59-86 F). Keep capsules and syrup away from light.
DOSING: For the treatment of HIV infection the recommended oral dose for adults is 100 mg every 4 hours. The intravenous dose is 1 to 2 mg/kg every 4 hours.
For children 3 months to 12 years old, the oral starting dose is 180 mg/m2 every 6 hours not to exceed 200 mg every 6 hours.
Infants should be given 2 mg/kg orally every 6 hours within 12 hours of birth and for 6 weeks or 1.5 mg/kg intravenously every 6 hours.
To prevent HIV transmission from mother to fetus, the dose is 100 mg five times daily or 200 mg three times daily. Treatment should be initiated between the 14th and 34th weeks of pregnancy and continued until the time of labor. During labor and delivery, 2mg/kg should be administered intravenously over 1 hr followed by 1 mg/kg/hr until the umbilical cord is clamped.
DRUG INTERACTIONS: Fluconazole (Diflucan), probenecid and trimethoprim (Trimpex) reduce the elimination of zidovudine and therefore increase the blood concentration of zidovudine. This can lead to increased side effects from zidovudine.
PREGNANCY: Zidovudine is used for preventing transmission of the HIV virus from mother to fetus.
NURSING MOTHERS: Although it is not known whether zidovudine is excreted in breast milk, HIV infected mothers should not breast feed because of the potential risk of transmitting HIV to an infant that is not infected.
Medically reviewed by Eni Williams, PharmD
Reference: FDA Prescribing Information
Medically Reviewed by a Doctor on 10/16/2015
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