Retrovir (zidovudine, ZDV, formerly called AZT)

What is the dosage for zidovudine?

  • For the treatment of HIV infection the recommended oral dose for adults is 100 mg every 4 hours. The intravenous dose is 1 to 2 mg/kg every 4 hours.
  • For children 3 months to 12 years old, the oral starting dose is 180 mg/m2 every 6 hours not to exceed 200 mg every 6 hours.
  • Infants should be given 2 mg/kg orally every 6 hours within 12 hours of birth and for 6 weeks or 1.5 mg/kg intravenously every 6 hours.
  • To prevent HIV transmission from mother to fetus, the dose is 100 mg five times daily or 200 mg three times daily.
  • Treatment should be initiated between the 14th and 34th weeks of pregnancy and continued until the time of labor.
  • During labor and delivery, 2mg/kg should be administered intravenously over 1 hr followed by 1 mg/kg/hr until the umbilical cord is clamped.

Which drugs or supplements interact with zidovudine?

  • Fluconazole (Diflucan), probenecid and trimethoprim (Trimpex) reduce the elimination of zidovudine and therefore increase the blood concentration of zidovudine. This can lead to increased side effects from zidovudine.
Medically Reviewed by a Doctor on 9/23/2016

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