USES: This medication is used in the management of HIV infections in symptomatic adults. This is not a cure for HIV infections.

HOW TO USE: This medication is given by injection by a health care professional. It is usually infused slowly into a vein over a period of 1 hour every 4 hours. For best results, take each dose at evenly spaced intervals around the clock. This will ensure a constant level of medication in your blood.

SIDE EFFECTS: This medication may cause nausea, vomiting, stomach upset, loss of appetite, headache, trouble sleeping, sweating, dizziness, altered taste, muscle aches, or pain/redness/swelling at the injection site. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Tell your doctor immediately if any of these unlikely but serious side effects occur: unusual tiredness, skin rash, fever, flu-like symptoms, chest pain, mental/mood changes, swelling of the feet or ankles, unusual bleeding or bruising, yellowing of the eyes or skin, dark urine, vision changes, seizures. A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.

PRECAUTIONS: Before using this medication, tell your doctor of any illness you may have had such as: liver or kidney disease, heart disease, major injury/surgery/infection, alcohol usage, blood or bleeding disorders, any allergies. This medication should be used only if clearly needed during pregnancy. Discuss the risks and benefits with your doctor. This drug is known to be excreted into breast milk. Avoid breast-feeding to prevent transmission of HIV to a child that may not be infected.

DRUG INTERACTIONS: This drug should not be used with the following medications because very serious interactions may occur: doxorubicin, ribavirin, stavudine. If you are currently using any of these medications, tell your doctor or pharmacist before starting zidovudine. Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: acetaminophen, amphotericin B, aspirin, atovaquone, cimetidine, co-trimoxazole, dapsone, fluconazole, flucytosine, ganciclovir, indomethacin, interferon, lorazepam, methadone, oxazepam, pentamidine, phenytoin, probenecid, rifamycins, valproic acid, drugs that suppress the bone marrow (such as vinblastine or vincristine). Do not start or stop any medicine without doctor or pharmacist approval.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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