Patients with respiratory diseases may experience breathing problems when treated with zanamivir due to irritation of the breathing tubes by the particles from the inhaler. If breathing problems occur, zanamivir should be discontinued. Patients who have asthma or other breathing problems that make them sensitive to inhaled particles should have a fast acting, inhaled bronchodilator available to treat any breathing problem that may occur when zanamivir is used.
GENERIC AVAILABLE: No
PREPARATIONS: Inhalation Powder: 5 mg per inhalation
STORAGE: Zanamivir should be stored at room temperature, 15 C to 30 C (59 F to 86 F)
DOSING: Zanamivir is administered by oral inhalation. The recommended dose is two inhalations (5 mg per inhalation) twice daily (approximately 12 hours apart) for five days. Two doses (separated by at least two hours) should be administered on the first day of treatment. For best results, treatment should begin as soon as symptoms develop. The recommended dose for prevention of influenza in a household setting is 10 mg once daily for 10 days. The recommended dose for preventing influenza in a community setting is 10 mg once daily for 28 days.
DRUG INTERACTIONS: Zanamivir potentially may interfere with the action of injections of live attenuated flu vaccine because zanamivir prevents viral replication. Therefore, live attenuated flu vaccine should not be administered from 2 weeks before to 48 hours after administration of zanamivir. Trivalent inactivated influenza vaccine can be administered while using zanamivir.
PREGNANCY: The Centers for Disease Control (CDC) states that pregnancy is not a contraindication for use of zanamivir in pregnant women because the benefits outweigh the risks.
Medically reviewed by Eni Williams, PharmD
Relenza FDA Prescribing Information
CDC.gov. What You Should Know About Flu Antiviral Drugs. September 17, 2013.
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