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- What is zaleplon, and how does it work (mechanism of action)?
- What brand names are available for zaleplon?
- Is zaleplon available as a generic drug?
- Do I need a prescription for zaleplon?
- What are the uses for zaleplon?
- What are the side effects of zaleplon?
- What is the dosage for zaleplon?
- Which drugs or supplements interact with zaleplon?
- Is zaleplon safe to take if I'm pregnant or breastfeeding?
- What else should I know about zaleplon?
What is the dosage for zaleplon?
The recommended dose is 5 to 20 mg at bedtime for assistance in falling asleep. Because of its short duration of activity, it is not effective for persons who wake up during the night. Zaleplon should be taken immediately before bedtime or after going to bed and experiencing difficulty falling asleep. Taking zaleplon with a high-fat meal slows its absorption and may also slow its onset of action.
Which drugs or supplements interact with zaleplon?
Rifampin reduces the amount of zaleplon in the blood by more than 80%. This could lead to a decrease in zaleplon's activity. Cimetidine (Tagamet) can increase the amount of zaleplon in the blood by 85% by reducing the breakdown of zaleplon in the liver. If cimetidine must be used, lower doses of zaleplon are suggested. Ketoconazole (Nizoral, Extina, Xolegel, Kuric), erythromycin and similar drugs that reduce breakdown of drugs in the liver also increase blood concentrations of zaleplon. The drowsiness that can occur with zaleplon is accentuated by alcohol, and, therefore, patients taking zaleplon should not drink alcoholic beverages. Imipramine (Tofranil, Tofranil-PM) and thioridazine also increase drowsiness when combined with zaleplon.
Report Problems to the Food and Drug Administration
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