Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
GENERIC NAME: zafirlukast
BRAND NAME: Accolate
DRUG CLASS AND MECHANISM: Zafirlukast is an oral leukotriene receptor antagonist used for treating asthma. Leukotrienes are a group of chemicals manufactured in the body from arachidonic acid. Release of leukotrienes within the body, for example, by allergic reactions, promotes inflammation in many diseases such as asthma, a disease in which inflammation occurs in the lungs. Zafirlukast blocks the binding of leukotriene types D4 (LTD4), and E4 (LTE4) and the promotion of inflammation. It was approved by the FDA in September 1996.
GENERIC AVAILABLE: Yes
PREPARATIONS: Tablets: 10 and 20 mg.
STORAGE: Tablets should be stored at room temperature, between 15 C and 30 C (59 F and 86 F).
PRESCRIBED FOR: Zafirlukast is used for the treatment of chronic asthma. It also is effective in preventing exercise-induced asthma and in relieving the symptoms of allergic rhinitis. For the treatment of asthma, zafirlukast starts working only after 3 to 14 days of therapy. Therefore, it should not be used for treating an acute asthmatic attack because immediate relief is needed.
DOSING: The recommended dose for treating asthma is 10 mg twice daily for children 5-11 years of age and 20 mg twice daily for individual 12 years of age and older. Food reduces the absorption of zafirlukast. Therefore, it should be taken either 1 hour before or 2 hours after meals.
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