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February 10, 2012

Your Cholesterol Profile - In Depth (cont.)

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Who should undergo standard lipid profile testing?

It is recommended that every adult over 20 should have lipid panel tests (total cholesterol, LDL cholesterol, HDL cholesterol, and triglyceride levels) every 5 years if LDL cholesterol is less than 130, and every 1-3 years if LDL cholesterol is borderline (between 130 and 160). This is particularly important for those with a family history of coronary artery disease. Once these cholesterol figures are known, the chance of developing heart disease can be determined in combination with other risk factors that play a role in its development.

Who should undergo testing for LDL cholesterol particle size and Lp(a) cholesterol levels?

The scientific analysis for the determination of LDL size and Lp(a) is relatively new and is not standardized from laboratory to laboratory. Thus, results will vary to some degree between different laboratories. Also, because the use of any specific laboratory test is not widespread, the cost of testing remains expensive.

Because of the cost and variability of testing, a determination of these cholesterol components is not necessary for everyone. Currently, persons who have been diagnosed with coronary artery disease whose risk factor profile would not otherwise predict coronary artery disease at the age at which it occurred, should be tested for these more specific cholesterol components. For example, if heart disease occurs at a young age without high LDL levels, high blood pressure, diabetes, or cigarette smoking, the physician and patient may consider testing for another risk factor such as small LDL particle size or elevated Lp(a).

Among persons without coronary heart disease, those with a family history of heart disease occurring early in life should be tested for these risk factors, which are predominantly determined by genetic inheritance. As the cost and accuracy of testing improves, the evaluation of these components should become more widespread.


Last Editorial Review: 4/13/2005



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