Wine

Are there any interactions with medications?

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Chlorpropamide (Diabinese)
Interaction Rating: Major Do not take this combination.

The body breaks down the alcohol in wine to get rid of it. Chlorpropamide (Diabinese) might decrease how quickly the body breaks down alcohol. Drinking wine and taking chlorpropamide (Diabinese) might cause a headache, vomiting, flushing, and other unpleasant reactions. Don't drink wine if you are taking chlorpropamide (Diabinese).

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Cisapride (Propulsid)
Interaction Rating: Major Do not take this combination.

Cisapride (Propulsid) might decrease how quickly the body gets rid of the alcohol in wine. Taking cisapride (Propulsid) along with wine might increase the effects and side effects of alcohol.

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Cyclosporine (Neoral, Sandimmune)
Interaction Rating: Major Do not take this combination.

Wine might increase how much cyclosporine (Neoral, Sandimmune) the body absorbs. Taking wine along with cyclosporine (Neoral, Sandimmune) might increase the side effects of cyclosporine.

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Disulfiram (Antabuse)
Interaction Rating: Major Do not take this combination.

The body breaks down the alcohol in wine to get rid of it. Disulfiram (Antabuse) decreases how quickly the body breaks down alcohol. Drinking wine and taking disulfiram (Antabuse) can cause a pounding headache, vomiting, flushing, and other unpleasant reactions. Don't drink any alcohol if you are taking disulfiram (Antabuse).

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Felodipine (Plendil)
Interaction Rating: Major Do not take this combination.

Red wine can change the way the body absorbs and breaks down felodipine. Drinking red wine while taking felodipine for high blood pressure might cause your blood pressure to go too low.

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Medications for depression (MAOIs)
Interaction Rating: Major Do not take this combination.

Wine contains a chemical called tyramine. Large amounts of tyramine can cause high blood pressure. But the body naturally breaks down tyramine to get rid of it. This usually prevents the tyramine from causing high blood pressure. Some medications used for depression stop the body from breaking down tyramine. This can cause there to be too much tyramine and lead to dangerously high blood pressure.

Some of these medications used for depression include phenelzine (Nardil), tranylcypromine (Parnate), and others.

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Medications for pain (Narcotic drugs)
Interaction Rating: Major Do not take this combination.

The body breaks down some medications for pain to get rid of them. The alcohol in wine might decrease how quickly the body gets rid of some medications for pain. Taking some medications for pain along with wine might increase the effects and side effects of some medications for pain.

Some medications for pain include meperidine (Demerol), hydrocodone, morphine, OxyContin, and many others.

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Medications that can harm the liver (Hepatotoxic drugs)
Interaction Rating: Major Do not take this combination.

The alcohol in wine can harm the liver. Drinking wine along with medication that can harm the liver can increase the risk of liver damage. Do not drink wine if you are taking a medication that can harm the liver.

Some medications that can harm the liver include acetaminophen (Tylenol and others), amiodarone (Cordarone), carbamazepine (Tegretol), isoniazid (INH), methotrexate (Rheumatrex), methyldopa (Aldomet), fluconazole (Diflucan), itraconazole (Sporanox), erythromycin (Erythrocin, Ilosone, others), phenytoin (Dilantin), lovastatin (Mevacor), pravastatin (Pravachol), simvastatin (Zocor), and many others.

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Metformin (Glucophage)
Interaction Rating: Major Do not take this combination.

Metformin (Glucophage) is broken down by the body in the liver. The alcohol in wine is also broken down in the body by the liver. Drinking wine and taking metformin (Glucophage) might cause serious side effects.

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Metronidazole (Flagyl)
Interaction Rating: Major Do not take this combination.

The alcohol in wine can interact with metronidazole (Flagyl). This can lead to upset stomach, vomiting, sweating, headache, and an increased heartbeat. Do not drink wine while taking metronidazole (Flagyl).

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Phenytoin (Dilantin)
Interaction Rating: Major Do not take this combination.

The body breaks down phenytoin (Dilantin) to get rid of it. The alcohol in wine might increase how quickly the body breaks down phenytoin (Dilantin). Drinking wine and taking phenytoin (Dilantin) might decrease the effectiveness of phenytoin (Dilantin) and increase the possibility of seizures.

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Sedative medications (Barbiturates)
Interaction Rating: Major Do not take this combination.

The alcohol in wine might cause sleepiness and drowsiness. Medications that cause sleepiness and drowsiness are called sedative medications. Taking wine along with sedative medications might cause too much sleepiness. Do not drink wine if you are taking sedative medications.

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Sedative medications (Benzodiazepines)
Interaction Rating: Major Do not take this combination.

The alcohol in wine might cause sleepiness and drowsiness. Medications that cause sleepiness and drowsiness are called sedative medications. Taking wine along with sedative medications might cause too much sleepiness. Do not drink wine if you are taking sedative medications.

Some of these sedative medications include clonazepam (Klonopin), diazepam (Valium), lorazepam (Ativan), and others.

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Sedative medications (CNS depressants)
Interaction Rating: Major Do not take this combination.

The alcohol in wine might cause sleepiness and drowsiness. Medications that cause sleepiness and drowsiness are called sedative medications. Drinking wine and taking sedative medications might cause too much sleepiness and other serious side effects.

Some sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others.

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Antibiotics (Sulfonamide antibiotics)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

The alcohol in wine can interact with some antibiotics. This can lead to upset stomach, vomiting, sweating, headache, and an increased heartbeat. Do not drink wine while taking antibiotics.

Some antibiotics that interact with wine include sulfamethoxazole (Gantanol), sulfasalazine (Azulfidine), sulfisoxazole (Gantrisin), trimethoprim/sulfamethoxazole (Bactrim, Septra), and others.

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Aspirin
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Aspirin can sometimes damage the stomach and cause ulcers and bleeding. The alcohol in wine can also damage the stomach. Taking aspirin along with wine might increase the chance of ulcers and bleeding in the stomach. Avoid taking wine and aspirin together.

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Cefamandole (Mandol)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

The alcohol in wine can interact with cefamandole (Mandol). This can lead to upset stomach, vomiting, sweating, headache, and an increased heartbeat. Do not drink wine while taking cefamandole (Mandol).

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Cefoperazone (Cefobid)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

The alcohol in wine can interact with cefoperazone (Cefobid). This can lead to upset stomach, vomiting, sweating, headache, and an increased heartbeat. Do not drink wine while taking cefoperazone (Cefobid).

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Erythromycin
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

The body breaks down the alcohol in wine to get rid of it. Erythromycin can decrease how quickly the body gets rid of alcohol. Drinking wine and taking erythromycin might increase the effects and side effects of alcohol.

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Griseofulvin (Fulvicin)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

The body breaks down the alcohol in wine to get rid of it. Griseofulvin (Fulvicin) decreases how quickly the body breaks down alcohol. Drinking wine and taking griseofulvin can cause a pounding headache, vomiting, flushing, and other unpleasant reactions. Don't drink any alcohol if you are taking griseofulvin.

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Medications that decrease stomach acid (H2-Blockers)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Some medications that decrease stomach acid might interact with the alcohol in wine. Drinking wine with some medications that decrease stomach acid might increase how much alcohol the body absorbs, and increase the risk of side effects of alcohol.

Some medications that decrease stomach acid and might interact with alcohol include cimetidine (Tagamet), ranitidine (Zantac), nizatidine (Axid), and famotidine (Pepcid).

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NSAIDs (Nonsteroidal anti-inflammatory drugs)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

NSAIDs are anti-inflammatory medications used for decreasing pain and swelling. NSAIDs can sometimes damage the stomach and intestines and cause ulcers and bleeding. The alcohol in wine can also damage the stomach and intestines. Taking NSAIDs along with wine might increase the chance of ulcers and bleeding in the stomach and intestines. Avoid taking wine and NSAIDs together.

Some NSAIDs include ibuprofen (Advil, Motrin, Nuprin, others), indomethacin (Indocin), naproxen (Aleve, Anaprox, Naprelan, Naprosyn), piroxicam (Feldene), aspirin, and others.

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Tolbutamide (Orinase)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

The body breaks down the alcohol in wine to get rid of it. Tolbutamide (Orinase) can decrease how quickly the body breaks down alcohol. Drinking wine and taking tolbutamide (Orinase) can cause pounding headache, vomiting, flushing, and other unpleasant reactions. Don't drink wine if you are taking tolbutamide (Orinase).

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Warfarin (Coumadin)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Warfarin (Coumadin) is used to slow blood clotting. The alcohol in wine can interact with warfarin (Coumadin). Drinking large amounts of alcohol can change the effectiveness of warfarin (Coumadin). Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.

Dosing considerations for Wine.

Alcohol intake is often measured in number of "drinks." One drink is equivalent to a 4 oz or a 120 mL glass of wine, 12 oz of beer, or 1 oz of spirits.

The following doses have been studied in scientific research:

BY MOUTH:

• For reducing the risk of heart disease and stroke: 1-2 drinks (120-240 mL) per day.
• For reducing the risk of heart failure: up to four drinks of wine per day.
• For reducing loss of thinking skills in older men: up to one drink per day.
• For reducing the risk of type 2 diabetes in healthy men: between two drinks per week and three or four drinks per day.
• For reducing the risk of heart disease in people with type 2 diabetes: up to seven drinks per week.
• For reducing the risk of infection with the ulcer-causing bacteria called Helicobacter pylori: more than 75 grams of alcohol from beverages such as wine.