Weber-Christian Disease (cont.)

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What is panniculitis?

The tissue layer under the skin (epidermis and dermis) is called the subcutaneous fat or panniculus. This subcutaneous tissue is very important in temperature regulation and protective insulation of the body. Inflammation of this essential layer of fatty tissue is called panniculitis. In panniculitis, the overlying skin typically appears as red or purplish lumps.

What are other symptoms of Weber-Christian disease?

Weber-Christian disease can also cause symptoms other than in the skin, such as fever, fatigue, nausea, vomiting, weight loss, and joint pain. Occasionally, inflammation occurs in other organs of the body to cause heart, lung, kidney, liver, and/or spleen problems. Liver involvement may first cause abdominal pain. The skin symptoms provide perhaps the most important clue to the diagnosis of Weber-Christian syndrome. Overall, symptoms with this syndrome may come and go, and relapses are common.

What causes Weber-Christian disease?

The cause of Weber-Christian disease or idiopathic lobular panniculitis is not known. Idiopathic means unknown cause. A misdirected immune reaction may play a role. The cause may be related to an abnormal bodily response to the normal inflammation.

Medically Reviewed by a Doctor on 4/8/2015

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