warfarin (Coumadin, Jantoven)

  • Medical Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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PREPARATIONS:

  • Tablets: 1, 2, 2.5, 3, 4, 5, 6, 5, 7.5 and 10 mg.
  • Powder for Injection: 5 mg/vial

STORAGE: Warfarin should be stored at room temperature, 59 F to 86 F (15 C to 30 C), in tight, light resistant container.

DOSAGE:

  • Warfarin may be taken with or without food.
  • Since warfarin is metabolized (inactivated) by the liver and then excreted by the kidneys, dosages need to be lowered in patients with liver and kidney dysfunction.
  • Frequent blood tests (INR test) are performed to measure the effect of warfarin and to adjust dosing.
  • There are published INR ranges for the various uses of warfarin.
  • Treatment usually is started at 2 to 5 mg once daily and the dose is adjusted based in INR tests.
  • Patients typically require 2 to 10 mg of warfarin daily.

DRUG INTERACTIONS:

Medically Reviewed by a Doctor on 8/5/2016

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