WARFARIN-ORAL (cont.)
DRUG INTERACTIONS: This drug should not be used with the following medications because very serious interactions may occur: imatinib, mifepristone. If you are currently using any of these medications, tell your doctor or pharmacist before starting warfarin. Many drugs and herbal products interact with warfarin. Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: acetaminophen (repeated use or large doses), allopurinol, aminoglutethimide, amiodarone, anabolic steroids (e.g., danazol, stanozolol), certain injectable cephalosporin antibiotics (e.g., cefamandole, cefotetan), macrolide antibiotics (e.g., erythromycin, clarithromycin), certain oral and injectable penicillin-type antibiotics (e.g., dicloxacillin, piperacillin), quinolone antibiotics (e.g., ciprofloxacin, levofloxacin), certain other antibiotics (e.g., chloramphenicol, metronidazole), azole antifungals (e.g., voriconazole, vaginal miconazole), barbiturates (e.g., phenobarbital), birth control pills, certain drugs to treat cancer (e.g., capecitabine, fluorouracil), carbamazepine, drugs to lower cholesterol or triglycerides (e.g., cholestyramine, fenofibrate, gemfibrozil, lovastatin, simvastatin), cimetidine, corticosteroids (e.g., prednisone), disulfiram, glucagon, griseofulvin, herbal/dietary products (e.g., bromelains, co-enzyme Q, danshen, dong quai, garlic, ginkgo biloba, ginseng, St. John's wort), nonsteroidal anti-inflammatory drugs (NSAIDs such as celecoxib, ibuprofen, topical methylsalicylate), omeprazole, propafenone, propoxyphene, quinidine, quinine, rifamycins (e.g., rifampin, rifabutin), certain sedatives (e.g., chloral hydrate, ethchlorvynol, glutethimide), sulfa drugs, sulfinpyrazone, SSRI antidepressants (e.g., fluoxetine, fluvoxamine), tamoxifen, drugs to treat thyroid disease (e.g., levothyroxine, propylthiouracil), vitamin E, vitamin K, zafirlukast. Check all prescription and nonprescription medicine labels carefully since many contain pain relievers/fever reducers (NSAIDs such as ibuprofen, naproxen, or aspirin) which can increase the risk of bleeding/anti-platelet effect when used with warfarin. Low-dose aspirin, as prescribed by your doctor for specific medical reasons such as heart attack or stroke prevention or to prevent clotting of artificial heart valves (usually these dosages are 81-325 mg per day), should be continued. Consult your doctor or pharmacist for more details. Related drugs (anti-platelet drugs such as clopidogrel, dipyridamole, ticlopidine) prescribed for specific medical reasons should be continued, unless otherwise directed by your doctor. Consult your doctor or pharmacist for more details including the possible serious side effects associated with ticlopidine (e.g., immune system problem, liver disease when used with warfarin). While taking warfarin, it is important to eat a normal, balanced diet. The amount of vitamin K in your body affects the way that warfarin works. It is best to avoid sudden changes in your diet, especially unusual increases or decreases in the amount of foods high in vitamin K (e.g., liver, broccoli, cauliflower, cabbage, Brussels sprouts, kale, spinach and other green leafy vegetables, green tea, and certain vitamin supplements). It is best to avoid strictly vegetarian diets that consist of foods high in vitamin K. This product can affect the results of certain lab tests. Make sure laboratory personnel and your doctors know you use this drug.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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